Found 16 Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase BTK' and Ligand = 'BDBM291522' TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Peking Union Medical College And Chinese Academy Of Medical Sciences
Curated by ChEMBL
Peking Union Medical College And Chinese Academy Of Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 1.80nMAssay Description:Inhibition of BTK (unknown origin) measured by ADP-Glo assayMore data for this Ligand-Target Pair
3D Structure (crystal)TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Peking Union Medical College And Chinese Academy Of Medical Sciences
Curated by ChEMBL
Peking Union Medical College And Chinese Academy Of Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of human BTK using fluorescein-labeled polyGAT peptide as substrate incubated for 30 mins by FRET assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Peking Union Medical College And Chinese Academy Of Medical Sciences
Curated by ChEMBL
Peking Union Medical College And Chinese Academy Of Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 8.90nMAssay Description:Covalent inhibition of N-terminal GST-fused human BTK (2-659(end) amino acids) expressed in baculovirus expression system using FITC-AHA-EEPLYWSFPAKK...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Peking Union Medical College And Chinese Academy Of Medical Sciences
Curated by ChEMBL
Peking Union Medical College And Chinese Academy Of Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 8.90nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Peking Union Medical College And Chinese Academy Of Medical Sciences
Curated by ChEMBL
Peking Union Medical College And Chinese Academy Of Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 22nMAssay Description:Inhibition of BTK phosphorylation at Tyr 223 residue in human Ramos cell incubated for 3 hrs by HTRF-based analysisMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Peking Union Medical College And Chinese Academy Of Medical Sciences
Curated by ChEMBL
Peking Union Medical College And Chinese Academy Of Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 61nMAssay Description:Inhibition of BTK in human PBMC cells assessed as reduction in anti-IgM-stimulated CD69 expression on B cells preincubated for 60 mins followed by go...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Peking Union Medical College And Chinese Academy Of Medical Sciences
Curated by ChEMBL
Peking Union Medical College And Chinese Academy Of Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 61nMAssay Description:Inhibition of BTK in vitamin D3 differentiated human THP1 cells assessed as inhibition of FCgammaR-induced IL8 production measured after 24 hrs by HT...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Peking Union Medical College And Chinese Academy Of Medical Sciences
Curated by ChEMBL
Peking Union Medical College And Chinese Academy Of Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 62nMAssay Description:Inhibition of full-length human recombinant BTK using FITC-Ahx-TSELKKVVALYDYMPMNAND-NH2 as substrate measured after 60 mins by caliper assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Peking Union Medical College And Chinese Academy Of Medical Sciences
Curated by ChEMBL
Peking Union Medical College And Chinese Academy Of Medical Sciences
Curated by ChEMBL
Affinity DataIC50: <100nMAssay Description:2.5× stocks of full-length human BTK (08-080) from CarnaBio USA, Inc., Natick, Mass., 1.6×ATP and appropriate kinKDR peptide substrate (FITC-AHA-EEPL...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Peking Union Medical College And Chinese Academy Of Medical Sciences
Curated by ChEMBL
Peking Union Medical College And Chinese Academy Of Medical Sciences
Curated by ChEMBL
Affinity DataIC50: <100nMpH: 7.5 T: 2°CAssay Description:The following describes a microfluidic, off-chip mobility shift kinase assay used to measure inherent potency of compounds against BTK enzyme. Compou...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Peking Union Medical College And Chinese Academy Of Medical Sciences
Curated by ChEMBL
Peking Union Medical College And Chinese Academy Of Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 320nMAssay Description:Inhibition of BTK in human B cells assessed as reduction in anti-IgM/IL4-stimulated CD69 expression on B cells preincubated for 60 mins followed by a...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Peking Union Medical College And Chinese Academy Of Medical Sciences
Curated by ChEMBL
Peking Union Medical College And Chinese Academy Of Medical Sciences
Curated by ChEMBL
Affinity DataIC50: <1.00E+3nMpH: 7.5 T: 2°CAssay Description:The following describes a microfluidic, off-chip mobility shift kinase assay used to measure inherent potency of compounds against BTK enzyme. Compou...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Peking Union Medical College And Chinese Academy Of Medical Sciences
Curated by ChEMBL
Peking Union Medical College And Chinese Academy Of Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 1.18E+3nMAssay Description:Inhibition of BTK in human basophils assessed as reduction in anti-IgE mouse IgG1 antibody Le2-stimulated CD63 expression on basophil preincubated fo...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Peking Union Medical College And Chinese Academy Of Medical Sciences
Curated by ChEMBL
Peking Union Medical College And Chinese Academy Of Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 8.60E+3nMAssay Description:Inhibition of BTK Cys481S mutant (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Peking Union Medical College And Chinese Academy Of Medical Sciences
Curated by ChEMBL
Peking Union Medical College And Chinese Academy Of Medical Sciences
Curated by ChEMBL
Affinity DataKd: 4.60nMAssay Description:Binding affinity to wild-type human full length BTK (M1 to S659 residues) expressed in mammalian expression system by Kinomescan methodMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Peking Union Medical College And Chinese Academy Of Medical Sciences
Curated by ChEMBL
Peking Union Medical College And Chinese Academy Of Medical Sciences
Curated by ChEMBL
Affinity DataKd: 16nMAssay Description:Binding affinity to DNA-tagged recombinant BTK (unknown origin) measured after 1 hr by biotinylated-ligand affinity bead-based qPCR analysisMore data for this Ligand-Target Pair
