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Found 3 Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase Lck' and Ligand = 'BDBM8793'
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))TBA
LigandPNGBDBM8793(7-[4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phen...)
Affinity DataIC50: <3nMAssay Description:Inhibition of His-tagged LCK (62 to 509 residues) (unknown origin) expressed in Sf9 insect cells at 10 uM using poly (Glu, Tyr) 4:1 as substrate incu...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))TBA
LigandPNGBDBM8793(7-[4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phen...)
Affinity DataIC50:  15nMpH: 7.4 T: 2°CAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))TBA
LigandPNGBDBM8793(7-[4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phen...)
Affinity DataIC50:  240nMAssay Description:Inhibition of human p56 Lck tyrosine kinase (lck64-509)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed