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Found 2 of ic50 for monomerid = 112465
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM112465(US8623885, 6)
Affinity DataIC50:  3.30nMpH: 7.6Assay Description:The FLT3 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a HTRF kinase assay. The FLT3 enzyme (GST-FLT3 fusion) was purchased f...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM112465(US8623885, 6)
Affinity DataIC50:  120nMpH: 7.4Assay Description:The CDK4 and CDK1 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a filtration kinase assay. The compounds, kinase and substrat...More data for this Ligand-Target Pair
In DepthDetails US Patent