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Found 6 of ic50 for monomerid = 370487
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Newlink Genetics

Curated by ChEMBL
LigandPNGBDBM370487(1-(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol- 5-yl...)
Affinity DataIC50:  31nMAssay Description:Inhibition of purified human IDO1 using L-tryptophan as substrate preincubated for 5 mins followed by substrate addition and measured after 15 mins b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Newlink Genetics

Curated by ChEMBL
LigandPNGBDBM370487(1-(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol- 5-yl...)
Affinity DataIC50:  130nMAssay Description:Inhibition of CYP3A4 (unknown origin) using midazolam as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Newlink Genetics

Curated by ChEMBL
LigandPNGBDBM370487(1-(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol- 5-yl...)
Affinity DataIC50: <1.00E+3nMAssay Description:The IC50 values for each compound were determined by testing the activity of IDO in a mixture containing 50 mM potassium phosphate buffer at pH 6.5; ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 2D6(Homo sapiens (Human))
Newlink Genetics

Curated by ChEMBL
LigandPNGBDBM370487(1-(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol- 5-yl...)
Affinity DataIC50:  1.95E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2B6(Homo sapiens (Human))
Newlink Genetics

Curated by ChEMBL
LigandPNGBDBM370487(1-(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol- 5-yl...)
Affinity DataIC50:  3.90E+4nMAssay Description:Inhibition of CYP2B6 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Newlink Genetics

Curated by ChEMBL
LigandPNGBDBM370487(1-(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol- 5-yl...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed