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Found 4 of ic50 for monomerid = 429724
LigandPNGBDBM429724(5-(3-(4-(3,4- difluoro-5- methoxyphenyl) piperidin...)
Affinity DataIC50:  12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
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TargetCollagenase 3(Homo sapiens (Human))
Galapagos

US Patent
LigandPNGBDBM429724(5-(3-(4-(3,4- difluoro-5- methoxyphenyl) piperidin...)
Affinity DataIC50: >100nMAssay Description:The basis for the assay is the cleavage of the substrate 390 MMP FRET Substrate I (Anaspec Cat# AS-27076) by human MMP13 (Chemicon, Cat#CC068).For th...More data for this Ligand-Target Pair
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TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Galapagos

US Patent
LigandPNGBDBM429724(5-(3-(4-(3,4- difluoro-5- methoxyphenyl) piperidin...)
Affinity DataIC50: >100nMAssay Description:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEMS INC...More data for this Ligand-Target Pair
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TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
Galapagos

US Patent
LigandPNGBDBM429724(5-(3-(4-(3,4- difluoro-5- methoxyphenyl) piperidin...)
Affinity DataIC50: >100nMAssay Description:The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID NO: 2) by human ADAMTS-5.For the dose res...More data for this Ligand-Target Pair
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In DepthDetails US Patent