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Found 6 of ic50 for monomerid = 8735
TargetEnoyl-[acyl-carrier-protein] reductase [NADH] FabI(Haemophilus influenzae)
Glaxosmithkline

LigandPNGBDBM8735((2E)-N-[(1,2-dimethyl-1H-indol-3-yl)methyl]-N-meth...)
Affinity DataIC50:  25nMT: 2°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADH] FabI(Escherichia coli)
Glaxosmithkline

LigandPNGBDBM8735((2E)-N-[(1,2-dimethyl-1H-indol-3-yl)methyl]-N-meth...)
Affinity DataIC50:  30nMpH: 6.5 T: 2°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus)
Glaxosmithkline

LigandPNGBDBM8735((2E)-N-[(1,2-dimethyl-1H-indol-3-yl)methyl]-N-meth...)
Affinity DataIC50:  60nMpH: 6.5 T: 2°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus)
Glaxosmithkline

LigandPNGBDBM8735((2E)-N-[(1,2-dimethyl-1H-indol-3-yl)methyl]-N-meth...)
Affinity DataIC50:  130nMAssay Description:Inhibition of Staphylococcus aureus FabI in the presence of NADH using crotonyl CoA as substrate by measuring NADH consumption rateMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADH] FabI(Haemophilus influenzae)
Glaxosmithkline

LigandPNGBDBM8735((2E)-N-[(1,2-dimethyl-1H-indol-3-yl)methyl]-N-meth...)
Affinity DataIC50:  390nMAssay Description:Inhibition of Haemophilus influenzae ATCC 51907 FabI assessed as by measuring NADH consumption rateMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTrans-2-enoyl-ACP reductase II(Streptococcus pneumoniae)
Glaxosmithkline

LigandPNGBDBM8735((2E)-N-[(1,2-dimethyl-1H-indol-3-yl)methyl]-N-meth...)
Affinity DataIC50: >3.00E+4nMT: 2°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed