Compile Data Set for Download or QSAR
maximum 50k data
Found 3 of ki for monomerid = 335438
TargetBeta-secretase 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM335438((3R,6S)-5-amino-6- cyclopropyl-3-(2-fluoro-5-((2- ...)
Affinity DataKi:  4.20nMAssay Description:The compounds of the invention were determined to be potent inhibitors of BACE-2 using the following assay. Inhibitor IC50s at purified human autoBAC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM335438((3R,6S)-5-amino-6- cyclopropyl-3-(2-fluoro-5-((2- ...)
Affinity DataKi:  4.5nMAssay Description:The compounds of the invention were determined to be potent inhibitors of BACE-1 using the following assay.The following reagents were used in this a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCathepsin D(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM335438((3R,6S)-5-amino-6- cyclopropyl-3-(2-fluoro-5-((2- ...)
Affinity DataKi:  4.01E+3nMAssay Description:The following reagents were used in this assay: Na+-Acetate pH 5.0; 1% Brij-35; Dimethyl Sulfoxide (DMSO); Purified human Cathepsin-D (>95% pure); As...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent