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TargetCannabinoid receptor 1(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM239139((E)-N-(2-Hydroxybutan-2-yl)-4-oxo-6-phenylhex-5-en...)
Affinity DataKi: >1.00E+4nM IC50: >1.00E+4nMAssay Description:Membranes from HEK-293 cells transfected with the human recombinant CB1 receptor(Bmax=2.5pmol/mg protein) and human recombinant CB2 receptor (B max=4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM239140((E)-N-(1,3-Dihydroxy-2-(hydroxymethyl)propan-2-yl)...)
Affinity DataKi: >1.00E+4nM IC50: >1.00E+4nMAssay Description:Membranes from HEK-293 cells transfected with the human recombinant CB1 receptor(Bmax=2.5pmol/mg protein) and human recombinant CB2 receptor (B max=4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM239141((E) Ethyl [2-(4-oxo-6-phenylhex)-5-enamido]acetate...)
Affinity DataKi: >1.00E+4nM IC50: >1.00E+4nMAssay Description:Membranes from HEK-293 cells transfected with the human recombinant CB1 receptor(Bmax=2.5pmol/mg protein) and human recombinant CB2 receptor (B max=4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM239142((E)-N-(2-Hydroxybutan-2-yl)-4-oxo-6-p-tolylhex-5-e...)
Affinity DataKi: >1.00E+4nM IC50: >1.00E+4nMAssay Description:Membranes from HEK-293 cells transfected with the human recombinant CB1 receptor(Bmax=2.5pmol/mg protein) and human recombinant CB2 receptor (B max=4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM239143((E)-N-(1,3-Dihydroxy-2-(hydroxymethylpropan-2-yl)-...)
Affinity DataKi: >1.00E+4nM IC50: >1.00E+4nMAssay Description:Membranes from HEK-293 cells transfected with the human recombinant CB1 receptor(Bmax=2.5pmol/mg protein) and human recombinant CB2 receptor (B max=4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM239144((E)-N-(4-Hydroxyphenyl)-4-oxo-6-p-tolylhex-5-enami...)
Affinity DataKi: >1.00E+4nM IC50: >1.00E+4nMAssay Description:Membranes from HEK-293 cells transfected with the human recombinant CB1 receptor(Bmax=2.5pmol/mg protein) and human recombinant CB2 receptor (B max=4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM239145((E)-6-[4-(Dimethylamino)phenyl]-N-(2-hydroxybutan-...)
Affinity DataKi: >1.00E+4nM IC50: >1.00E+4nMAssay Description:Membranes from HEK-293 cells transfected with the human recombinant CB1 receptor(Bmax=2.5pmol/mg protein) and human recombinant CB2 receptor (B max=4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM239146((E)-Ethyl 2-(6-(3,4-dimethoxyphenyl)-4-oxohex-5-en...)
Affinity DataKi: >1.00E+4nM IC50: >1.00E+4nMAssay Description:Membranes from HEK-293 cells transfected with the human recombinant CB1 receptor(Bmax=2.5pmol/mg protein) and human recombinant CB2 receptor (B max=4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM239147((E)-6-(3,4-Dimethoxyphenyl)-N-(2-hydroxybutan-2-yl...)
Affinity DataKi: >1.00E+4nM IC50: >1.00E+4nMAssay Description:Membranes from HEK-293 cells transfected with the human recombinant CB1 receptor(Bmax=2.5pmol/mg protein) and human recombinant CB2 receptor (B max=4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM239148((E)-6-(4-(Benzyloxy)phenyl)-N-(2-hydroxybutan-2-yl...)
Affinity DataKi: >1.00E+4nM IC50: >1.00E+4nMAssay Description:Membranes from HEK-293 cells transfected with the human recombinant CB1 receptor(Bmax=2.5pmol/mg protein) and human recombinant CB2 receptor (B max=4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM239149((E)-Ethyl 2-(6-(4-(benzyloxy)phenyl)-4-oxohex-5-en...)
Affinity DataKi: >1.00E+4nM IC50: >1.00E+4nMAssay Description:Membranes from HEK-293 cells transfected with the human recombinant CB1 receptor(Bmax=2.5pmol/mg protein) and human recombinant CB2 receptor (B max=4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM239150((E)-4-Acetamidophenyl 4-oxo-6-phenylhex-5-enoate (...)
Affinity DataKi: >1.00E+4nM IC50: >1.00E+4nMAssay Description:Membranes from HEK-293 cells transfected with the human recombinant CB1 receptor(Bmax=2.5pmol/mg protein) and human recombinant CB2 receptor (B max=4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM239152(N-(2-Hydroxybutan-2-yl)-2-(4-naphthalen-1-ylamino)...)
Affinity DataKi: >1.00E+4nM IC50: >1.00E+4nMAssay Description:Membranes from HEK-293 cells transfected with the human recombinant CB1 receptor(Bmax=2.5pmol/mg protein) and human recombinant CB2 receptor (B max=4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM239153(Ethyl 2-(4-(naphthalen-1-ylamino)-4-oxobutanamido)...)
Affinity DataKi: >1.00E+4nM IC50: >1.00E+4nMAssay Description:Membranes from HEK-293 cells transfected with the human recombinant CB1 receptor(Bmax=2.5pmol/mg protein) and human recombinant CB2 receptor (B max=4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM239154(4-Acetamidophenyl 4-(naphthalen-1-ylamino)-4-oxobu...)
Affinity DataKi: >1.00E+4nM IC50: >1.00E+4nMAssay Description:Membranes from HEK-293 cells transfected with the human recombinant CB1 receptor(Bmax=2.5pmol/mg protein) and human recombinant CB2 receptor (B max=4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM239139((E)-N-(2-Hydroxybutan-2-yl)-4-oxo-6-phenylhex-5-en...)
Affinity DataKi: >1.00E+4nM IC50: >1.00E+4nMAssay Description:Membranes from HEK-293 cells transfected with the human recombinant CB1 receptor(Bmax=2.5pmol/mg protein) and human recombinant CB2 receptor (B max=4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM239140((E)-N-(1,3-Dihydroxy-2-(hydroxymethyl)propan-2-yl)...)
Affinity DataKi: >1.00E+4nM IC50: >1.00E+4nMAssay Description:Membranes from HEK-293 cells transfected with the human recombinant CB1 receptor(Bmax=2.5pmol/mg protein) and human recombinant CB2 receptor (B max=4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM239141((E) Ethyl [2-(4-oxo-6-phenylhex)-5-enamido]acetate...)
Affinity DataKi: >1.00E+4nM IC50: >1.00E+4nMAssay Description:Membranes from HEK-293 cells transfected with the human recombinant CB1 receptor(Bmax=2.5pmol/mg protein) and human recombinant CB2 receptor (B max=4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM239142((E)-N-(2-Hydroxybutan-2-yl)-4-oxo-6-p-tolylhex-5-e...)
Affinity DataKi: >1.00E+4nM IC50: >1.00E+4nMAssay Description:Membranes from HEK-293 cells transfected with the human recombinant CB1 receptor(Bmax=2.5pmol/mg protein) and human recombinant CB2 receptor (B max=4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM239143((E)-N-(1,3-Dihydroxy-2-(hydroxymethylpropan-2-yl)-...)
Affinity DataKi: >1.00E+4nM IC50: >1.00E+4nMAssay Description:Membranes from HEK-293 cells transfected with the human recombinant CB1 receptor(Bmax=2.5pmol/mg protein) and human recombinant CB2 receptor (B max=4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM239144((E)-N-(4-Hydroxyphenyl)-4-oxo-6-p-tolylhex-5-enami...)
Affinity DataKi: >1.00E+4nM IC50: >1.00E+4nMAssay Description:Membranes from HEK-293 cells transfected with the human recombinant CB1 receptor(Bmax=2.5pmol/mg protein) and human recombinant CB2 receptor (B max=4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM239145((E)-6-[4-(Dimethylamino)phenyl]-N-(2-hydroxybutan-...)
Affinity DataKi: >1.00E+4nM IC50: >1.00E+4nMAssay Description:Membranes from HEK-293 cells transfected with the human recombinant CB1 receptor(Bmax=2.5pmol/mg protein) and human recombinant CB2 receptor (B max=4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM239146((E)-Ethyl 2-(6-(3,4-dimethoxyphenyl)-4-oxohex-5-en...)
Affinity DataKi: >1.00E+4nM IC50: >1.00E+4nMAssay Description:Membranes from HEK-293 cells transfected with the human recombinant CB1 receptor(Bmax=2.5pmol/mg protein) and human recombinant CB2 receptor (B max=4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM239147((E)-6-(3,4-Dimethoxyphenyl)-N-(2-hydroxybutan-2-yl...)
Affinity DataKi: >1.00E+4nM IC50: >1.00E+4nMAssay Description:Membranes from HEK-293 cells transfected with the human recombinant CB1 receptor(Bmax=2.5pmol/mg protein) and human recombinant CB2 receptor (B max=4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM239148((E)-6-(4-(Benzyloxy)phenyl)-N-(2-hydroxybutan-2-yl...)
Affinity DataKi: >1.00E+4nM IC50: >1.00E+4nMAssay Description:Membranes from HEK-293 cells transfected with the human recombinant CB1 receptor(Bmax=2.5pmol/mg protein) and human recombinant CB2 receptor (B max=4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM239149((E)-Ethyl 2-(6-(4-(benzyloxy)phenyl)-4-oxohex-5-en...)
Affinity DataKi: >1.00E+4nM IC50: >1.00E+4nMAssay Description:Membranes from HEK-293 cells transfected with the human recombinant CB1 receptor(Bmax=2.5pmol/mg protein) and human recombinant CB2 receptor (B max=4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM239150((E)-4-Acetamidophenyl 4-oxo-6-phenylhex-5-enoate (...)
Affinity DataKi: >1.00E+4nM IC50: >1.00E+4nMAssay Description:Membranes from HEK-293 cells transfected with the human recombinant CB1 receptor(Bmax=2.5pmol/mg protein) and human recombinant CB2 receptor (B max=4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM239151((E)-6-(Biphenyl-4-yl)-N-(2-hydroxybutan-2-yl)-4-ox...)
Affinity DataKi: >1.00E+4nM IC50: >1.00E+4nMAssay Description:Membranes from HEK-293 cells transfected with the human recombinant CB1 receptor(Bmax=2.5pmol/mg protein) and human recombinant CB2 receptor (B max=4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM239152(N-(2-Hydroxybutan-2-yl)-2-(4-naphthalen-1-ylamino)...)
Affinity DataKi: >1.00E+4nM IC50: >1.00E+4nMAssay Description:Membranes from HEK-293 cells transfected with the human recombinant CB1 receptor(Bmax=2.5pmol/mg protein) and human recombinant CB2 receptor (B max=4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM239153(Ethyl 2-(4-(naphthalen-1-ylamino)-4-oxobutanamido)...)
Affinity DataKi: >1.00E+4nM IC50: >1.00E+4nMAssay Description:Membranes from HEK-293 cells transfected with the human recombinant CB1 receptor(Bmax=2.5pmol/mg protein) and human recombinant CB2 receptor (B max=4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM239154(4-Acetamidophenyl 4-(naphthalen-1-ylamino)-4-oxobu...)
Affinity DataKi: >1.00E+4nM IC50: >1.00E+4nMAssay Description:Membranes from HEK-293 cells transfected with the human recombinant CB1 receptor(Bmax=2.5pmol/mg protein) and human recombinant CB2 receptor (B max=4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM239151((E)-6-(Biphenyl-4-yl)-N-(2-hydroxybutan-2-yl)-4-ox...)
Affinity DataKi: >1.00E+4nM IC50: >1.00E+4nMAssay Description:Membranes from HEK-293 cells transfected with the human recombinant CB1 receptor(Bmax=2.5pmol/mg protein) and human recombinant CB2 receptor (B max=4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50154294(CHEMBL3774647)
Affinity DataIC50:  0.400nMAssay Description:Displacement of [3H]-E2 from human ER-alpha incubated for 16 to 20 hrs by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM20608(4-Hydroxytamoxifen | 4-Hydroxytamoxifen (9) | 4-[(...)
Affinity DataIC50:  0.5nMAssay Description:Displacement of [3H]-E2 from human ER-alpha incubated for 16 to 20 hrs by liquid scintillation counting analysisMore data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50592246(T3-CLK)
Affinity DataIC50:  0.670nMAssay Description:Inhibition of N-terminal FLAG-tagged human Clk1 using myelin basic protein as substrate preincubated for 10 mins followed by ATP addition measured af...More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50154340(CHEMBL3775016)
Affinity DataIC50:  0.800nMAssay Description:Displacement of [3H]-E2 from human ER-alpha incubated for 16 to 20 hrs by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50566435(CHEMBL4872902)
Affinity DataIC50:  1nMAssay Description:Inhibition of recombinant full length GST-tagged PDE5A1 (unknown origin) expressed in baculovirus infected Sf9 insect cells using TAMRA-cGMP as subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50592247(CHEMBL5200367)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human recombinant GST-tagged Clk1 (129 to 484 residues) expressed in Escherichia coli expression system using GRSRSRSRSRSRSRSR peptide ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEstrogen receptor(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50154339(CHEMBL3774660)
Affinity DataIC50:  1.30nMAssay Description:Displacement of [3H]-E2 from human ER-alpha incubated for 16 to 20 hrs by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50237049(CHEMBL3133904)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of human recombinant GST-tagged EGFR (668 to 1210 residues) cytoplasmic domain expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50335827((6R,12aR)6-(2,4-Dichlorophenyl)-2-ethyl-2,3,6,7,12...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant PDE5A-mediated hydrolysis of cGMP after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50335827((6R,12aR)6-(2,4-Dichlorophenyl)-2-ethyl-2,3,6,7,12...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant PDE5 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50237048(CHEMBL3132872)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of human recombinant GST-tagged EGFR (668 to 1210 residues) cytoplasmic domain expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK4(Mus musculus)
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50239782(CHEMBL4082113)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of recombinant GST-tagged mouse CLK4 using GRSRSRSRSRSR as substrate after 30 mins in presence of [gamma-32P]-ATP by scintillation countin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50592247(CHEMBL5200367)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of human recombinant GST-tagged Clk2 expressed in Baculovirus expression system using GRSRSRSRSRSRSRSR peptide as substrate preincubated f...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM14390(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)
Affinity DataIC50:  3nMAssay Description:Inhibition of recombinant full length GST-tagged PDE5A1 (unknown origin) expressed in baculovirus infected Sf9 insect cells using TAMRA-cGMP as subst...More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM14777((2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,1...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant PDE5A-mediated hydrolysis of cGMP after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM14390(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human full length His-tagged PDE5A1 expressed in baculovirus infected Sf9 insect cells using [3H]-cGMP as substrate preincubated for 15...More data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM50469211(CHEMBL4283503)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged DYRK1A expressed in Escherichia coli BL21(DE3) using KKISGRLSPIMTEQ-NH2 as substrate after 15 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
German University In Cairo

Curated by ChEMBL
LigandPNGBDBM14777((2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,1...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human recombinant PDE5 after 1.5 hrs by fluorescent polarization assayMore data for this Ligand-Target Pair
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