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Tyrosine-protein kinase BTK(Homo sapiens (Human))
Korea Research Institute of Chemical Technology

US Patent

BDBM512399(US11084824, Example 63)

IC50: 2.13nMAssay Description:BTK enzyme evaluation with each compound of examples of the invention was performed by using BTK enzyme inhibition diagnosis kit (Cisbio, Codolet, Fr...More data for this Ligand-Target Pair

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Details US Patent

Filter my 36 hits

Targets 34▿
- Mitogen-activated protein kinase kinase kinase 5 2
- Tyrosine-protein kinase Lyn 2
- Tyrosine-protein kinase Lck 1
- Dual specificity protein kinase TTK 1
- Mitogen-activated protein kinase 3 1
- Insulin-like growth factor 1 receptor 1
- Receptor tyrosine-protein kinase erbB-4 1
- Receptor tyrosine-protein kinase erbB-2 1
- Epidermal growth factor receptor 1
- Mitogen-activated protein kinase 8 1
- Angiopoietin-1 receptor 1
- Mast/stem cell growth factor receptor Kit 1
- Hepatocyte growth factor receptor 1
- Mitogen-activated protein kinase 14 1
- Serine/threonine-protein kinase B-raf 1
- Aurora kinase B 1
- Vascular endothelial growth factor receptor 2 1
- Insulin receptor 1
- Fibroblast growth factor receptor 1 1
- Glycogen synthase kinase-3 beta 1
- Fibroblast growth factor receptor 3 1
- Vascular endothelial growth factor receptor 1 1
- Serine/threonine-protein kinase PLK1 1
- Cytoplasmic tyrosine-protein kinase BMX 1
- Inhibitor of nuclear factor kappa-B kinase subunit beta 1
- Nuclear receptor subfamily 2 group C member 2 1
- Mitogen-activated protein kinase kinase kinase 1 1
- Tyrosine-protein kinase CSK 1
- Protein kinase C theta type 1
- Platelet-derived growth factor receptor alpha 1
- Dual specificity mitogen-activated protein kinase kinase 1 1
- Dual specificity mitogen-activated protein kinase kinase 5 1
- Tyrosine-protein kinase ZAP-70 1
- Platelet-derived growth factor receptor beta 1
Publications 1▿
- Bioorg Med Chem 21: 2250-61 (2013) 36
Institutions 1▿
- Takeda Pharmaceutical 36
Affinity: 24 to 1.0E+4 nM▿
- IC50 36
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 0