Compile Data Set for Download or QSAR
maximum 50k data
Found 61 Enz. Inhib. hit(s) with all data for entry = 50031395
LigandPNGBDBM50312614(4-methyl-5-(6-{[4-(methylsulfonyl)piperazin-1-yl]m...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of recombinant PI3Kdelta assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312612(3-[6-(4-Methanesulfonyl-piperazin-1-ylmethyl)-4-mo...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of recombinant PI3Kdelta assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312614(4-methyl-5-(6-{[4-(methylsulfonyl)piperazin-1-yl]m...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of recombinant PI3Kalpha assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312609((3-(6-((4-(Methylsulfonyl)piperazin-1-yl)methyl)-4...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of recombinant PI3Kdelta assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312612(3-[6-(4-Methanesulfonyl-piperazin-1-ylmethyl)-4-mo...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of recombinant PI3Kalpha assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312609((3-(6-((4-(Methylsulfonyl)piperazin-1-yl)methyl)-4...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of recombinant PI3Kalpha assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312606(5-(6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of recombinant PI3Kalpha assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312606(5-(6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-...)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of recombinant PI3Kdelta assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25028(4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpipera...)
Affinity DataIC50:  3nMAssay Description:Inhibition of recombinant PI3Kdelta assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
LigandPNGBDBM25028(4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpipera...)
Affinity DataIC50:  3nMAssay Description:Inhibition of recombinant PI3Kalpha assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312613(2-(2-(2-Aminopyrimidin-5-yl)-4-morpholinothieno[3,...)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of recombinant PI3Kalpha assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312605(2-(2-(2-amino-4-methylpyrimidin-5-yl)-4-morpholino...)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of recombinant PI3Kalpha assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312614(4-methyl-5-(6-{[4-(methylsulfonyl)piperazin-1-yl]m...)
Affinity DataIC50:  5.20nMAssay Description:Inhibition of recombinant PI3Kgamma assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
LigandPNGBDBM50312605(2-(2-(2-amino-4-methylpyrimidin-5-yl)-4-morpholino...)
Affinity DataIC50:  5.20nMAssay Description:Inhibition of recombinant PI3Kdelta assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312607(5-(6-{[4-(methylsulfonyl)piperazin-1-yl]methyl}-4-...)
Affinity DataIC50:  5.5nMAssay Description:Inhibition of recombinant PI3Kalpha assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312614(4-methyl-5-(6-{[4-(methylsulfonyl)piperazin-1-yl]m...)
Affinity DataIC50:  6.20nMAssay Description:Inhibition of recombinant PI3Kbeta assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312607(5-(6-{[4-(methylsulfonyl)piperazin-1-yl]methyl}-4-...)
Affinity DataIC50:  6.60nMAssay Description:Inhibition of recombinant PI3Kdelta assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312606(5-(6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-...)
Affinity DataIC50:  8.40nMAssay Description:Inhibition of recombinant PI3Kgamma assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312612(3-[6-(4-Methanesulfonyl-piperazin-1-ylmethyl)-4-mo...)
Affinity DataIC50:  11nMAssay Description:Inhibition of recombinant PI3Kbeta assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312613(2-(2-(2-Aminopyrimidin-5-yl)-4-morpholinothieno[3,...)
Affinity DataIC50:  12nMAssay Description:Inhibition of recombinant PI3Kbeta assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312611(6-(4-Methanesulfonyl-piperazin-1-ylmethyl)-4-morph...)
Affinity DataIC50:  12nMAssay Description:Inhibition of recombinant PI3Kdelta assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312611(6-(4-Methanesulfonyl-piperazin-1-ylmethyl)-4-morph...)
Affinity DataIC50:  14nMAssay Description:Inhibition of recombinant PI3Kbeta assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312609((3-(6-((4-(Methylsulfonyl)piperazin-1-yl)methyl)-4...)
Affinity DataIC50:  14nMAssay Description:Inhibition of recombinant PI3Kbeta assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312605(2-(2-(2-amino-4-methylpyrimidin-5-yl)-4-morpholino...)
Affinity DataIC50:  15nMAssay Description:Inhibition of recombinant PI3Kgamma assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312609((3-(6-((4-(Methylsulfonyl)piperazin-1-yl)methyl)-4...)
Affinity DataIC50:  15nMAssay Description:Inhibition of recombinant PI3Kgamma assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
LigandPNGBDBM50312613(2-(2-(2-Aminopyrimidin-5-yl)-4-morpholinothieno[3,...)
Affinity DataIC50:  16nMAssay Description:Inhibition of recombinant PI3Kdelta assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312613(2-(2-(2-Aminopyrimidin-5-yl)-4-morpholinothieno[3,...)
Affinity DataIC50:  16nMAssay Description:Inhibition of recombinant PI3Kgamma assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312616(2-[2-(2-Amino-4-methyl-pyrimidin-5-yl)-4-morpholin...)
Affinity DataIC50:  16nMAssay Description:Inhibition of recombinant PI3Kalpha assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312611(6-(4-Methanesulfonyl-piperazin-1-ylmethyl)-4-morph...)
Affinity DataIC50:  19nMAssay Description:Inhibition of recombinant PI3Kgamma assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312612(3-[6-(4-Methanesulfonyl-piperazin-1-ylmethyl)-4-mo...)
Affinity DataIC50:  20nMAssay Description:Inhibition of recombinant PI3Kgamma assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312611(6-(4-Methanesulfonyl-piperazin-1-ylmethyl)-4-morph...)
Affinity DataIC50:  21nMAssay Description:Inhibition of recombinant PI3Kalpha assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312615(2-(2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]py...)
Affinity DataIC50:  22nMAssay Description:Inhibition of recombinant PI3Kalpha assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312605(2-(2-(2-amino-4-methylpyrimidin-5-yl)-4-morpholino...)
Affinity DataIC50:  25nMAssay Description:Inhibition of recombinant PI3Kbeta assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312617(1-(2-(1H-Indazol-4-yl)-4-morpholinothieno[3,2-d]py...)
Affinity DataIC50:  28nMAssay Description:Inhibition of recombinant PI3Kalpha assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312618((2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]pyri...)
Affinity DataIC50:  29nMAssay Description:Inhibition of recombinant PI3Kalpha assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50312606(5-(6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-...)
Affinity DataIC50:  29nMAssay Description:Inhibition of human recombinant mTOR by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50312613(2-(2-(2-Aminopyrimidin-5-yl)-4-morpholinothieno[3,...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human recombinant mTOR by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25028(4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpipera...)
Affinity DataIC50:  32nMAssay Description:Inhibition of recombinant PI3Kbeta assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
LigandPNGBDBM50312607(5-(6-{[4-(methylsulfonyl)piperazin-1-yl]methyl}-4-...)
Affinity DataIC50:  33nMAssay Description:Inhibition of recombinant PI3Kgamma assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
LigandPNGBDBM50312606(5-(6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-...)
Affinity DataIC50:  38nMAssay Description:Inhibition of recombinant PI3Kbeta assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312607(5-(6-{[4-(methylsulfonyl)piperazin-1-yl]methyl}-4-...)
Affinity DataIC50:  60nMAssay Description:Inhibition of recombinant PI3Kbeta assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25028(4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpipera...)
Affinity DataIC50:  66nMAssay Description:Inhibition of recombinant PI3Kgamma assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
LigandPNGBDBM50312608(4-[6-(4-Methanesulfonyl-piperazin-1-ylmethyl)-4-mo...)
Affinity DataIC50:  100nMAssay Description:Inhibition of recombinant PI3Kdelta assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50312615(2-(2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]py...)
Affinity DataIC50:  130nMAssay Description:Inhibition of human recombinant mTOR by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312608(4-[6-(4-Methanesulfonyl-piperazin-1-ylmethyl)-4-mo...)
Affinity DataIC50:  240nMAssay Description:Inhibition of recombinant PI3Kalpha assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM25028(4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpipera...)
Affinity DataIC50:  310nMAssay Description:Inhibition of human recombinant mTOR by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312610(6-(4-Methanesulfonyl-piperazin-1-ylmethyl)-4-morph...)
Affinity DataIC50:  310nMAssay Description:Inhibition of recombinant PI3Kdelta assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50312613(2-(2-(2-Aminopyrimidin-5-yl)-4-morpholinothieno[3,...)
Affinity DataIC50:  371nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312619((4-(6-((4-(Methylsulfonyl)piperazin-1-yl)methyl)-2...)
Affinity DataIC50:  430nMAssay Description:Inhibition of recombinant PI3Kalpha assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50312613(2-(2-(2-Aminopyrimidin-5-yl)-4-morpholinothieno[3,...)
Affinity DataIC50:  591nMAssay Description:Inhibition of MLK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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