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Found 6 Enz. Inhib. hit(s) with all data for entry = 50033508
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Cemm-Research Center For Molecular Medicine Of The Austrian Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50178769((+/-)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-c...)
Affinity DataIC50:  38nMAssay Description:Inhibition of human recombinant GST-tagged SIRT1 expressed in 293T cells by Fluor de Lys fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Cemm-Research Center For Molecular Medicine Of The Austrian Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50216689(2-cyano-3-(5-(2,5-dichlorophenyl)furan-2-yl)-N-(qu...)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of SIRT2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Cemm-Research Center For Molecular Medicine Of The Austrian Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50346541(CHEMBL1797749)
Affinity DataIC50:  1.25E+4nMAssay Description:Inhibition of SIRT2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Cemm-Research Center For Molecular Medicine Of The Austrian Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50178769((+/-)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-c...)
Affinity DataIC50:  1.96E+4nMAssay Description:Inhibition of human recombinant GST-tagged SIRT2 by Fluor de Lys fluorescence assayMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Cemm-Research Center For Molecular Medicine Of The Austrian Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50156760((E)-2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N...)
Affinity DataIC50:  3.80E+4nMAssay Description:Inhibition of human recombinant GST-tagged SIRT2 using acetylated HeLa histones substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Cemm-Research Center For Molecular Medicine Of The Austrian Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50156760((E)-2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N...)
Affinity DataIC50:  6.80E+4nMAssay Description:Inhibition of human recombinant GST-tagged SIRT1 using acetylated HeLa histones substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed