Found 355 Enz. Inhib. hit(s) with all data for entry = 50049182 
Affinity DataIC50: 5nMAssay Description:Inhibition of C-terminal His-tagged Syk catalytic domain (356 to 635 residues) (unknown origin) using biotin-TYR1 as substrate after 60 mins by TR-FR...More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of C-terminal His-tagged Syk catalytic domain (356 to 635 residues) (unknown origin) using biotin-TYR1 as substrate after 60 mins by TR-FR...More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of C-terminal His-tagged Syk catalytic domain (356 to 635 residues) (unknown origin) using biotin-TYR1 as substrate after 60 mins by TR-FR...More data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibition of C-terminal His-tagged Syk catalytic domain (356 to 635 residues) (unknown origin) using biotin-TYR1 as substrate after 60 mins by TR-FR...More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of Syk (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Inhibition of Syk (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of C-terminal His-tagged Syk catalytic domain (356 to 635 residues) (unknown origin) using biotin-TYR1 as substrate after 60 mins by TR-FR...More data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition of C-terminal His-tagged Syk catalytic domain (356 to 635 residues) (unknown origin) using biotin-TYR1 as substrate after 60 mins by TR-FR...More data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibitory concentration against cyclin dependent kinase-2 (CDK2)/Cyclin EMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibitory concentration required against 5-lipoxygenase activity in cytosolic fractions of human neutrophilsMore data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Inhibition of C-terminal His-tagged Syk catalytic domain (356 to 635 residues) (unknown origin) using biotin-TYR1 as substrate after 60 mins by TR-FR...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 24nMAssay Description:Inhibition of Syk (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 43nMAssay Description:Inhibition of C-terminal His-tagged Syk catalytic domain (356 to 635 residues) (unknown origin) using biotin-TYR1 as substrate after 60 mins by TR-FR...More data for this Ligand-Target Pair
Affinity DataIC50: 45nMAssay Description:Inhibition of C-terminal His-tagged Syk catalytic domain (356 to 635 residues) (unknown origin) using biotin-TYR1 as substrate after 60 mins by TR-FR...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 46nMAssay Description:Inhibition of PAK4 kinase domain (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 47nMAssay Description:Inhibition of C-terminal His-tagged Syk catalytic domain (356 to 635 residues) (unknown origin) using biotin-TYR1 as substrate after 60 mins by TR-FR...More data for this Ligand-Target Pair
Affinity DataIC50: 57nMAssay Description:Inhibition of JAK2 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 61nMAssay Description:In vitro antagonist activity at recombinant human Metabotropic glutamate receptor 2 expressed in RGT cells.More data for this Ligand-Target Pair
Affinity DataIC50: 63nMAssay Description:Inhibition of C-terminal His-tagged Syk catalytic domain (356 to 635 residues) (unknown origin) using biotin-TYR1 as substrate after 60 mins by TR-FR...More data for this Ligand-Target Pair
Affinity DataIC50: 64nMAssay Description:Inhibition of C-terminal His-tagged Syk catalytic domain (356 to 635 residues) (unknown origin) using biotin-TYR1 as substrate after 60 mins by TR-FR...More data for this Ligand-Target Pair
Affinity DataIC50: 69nMAssay Description:Inhibition of Syk (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 81nMAssay Description:Inhibition of C-terminal His-tagged Syk catalytic domain (356 to 635 residues) (unknown origin) using biotin-TYR1 as substrate after 60 mins by TR-FR...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 82nMAssay Description:Inhibition of JNK1 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetRibosomal protein S6 kinase alpha-3(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 83nMAssay Description:Inhibitory concentration against cyclin dependent kinase-2 (CDK2)/Cyclin EMore data for this Ligand-Target Pair
Affinity DataIC50: 97nMAssay Description:Inhibition of Syk (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 2(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 115nMAssay Description:Inhibitory concentration against cyclin dependent kinase-2 (CDK2)/Cyclin EMore data for this Ligand-Target Pair
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 126nMAssay Description:Inhibition of TrkB (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 132nMAssay Description:Inhibition of RET (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 136nMAssay Description:Inhibition of FAK (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 139nMAssay Description:Inhibition of MEK1 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 156nMAssay Description:Inhibitory concentration against cyclin dependent kinase-2 (CDK2)/Cyclin EMore data for this Ligand-Target Pair
TargetHepatocyte growth factor-like protein(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 177nMAssay Description:Inhibition of MST1 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 179nMAssay Description:Inhibition of C-terminal His-tagged Syk catalytic domain (356 to 635 residues) (unknown origin) using biotin-TYR1 as substrate after 60 mins by TR-FR...More data for this Ligand-Target Pair
Affinity DataIC50: 201nMAssay Description:Inhibition of Fyn (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 211nMAssay Description:Inhibition of CLK2 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 236nMAssay Description:Inhibition of JAK2 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 248nMAssay Description:Inhibition of ROCK2 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 266nMAssay Description:Inhibition of ALK (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetLeukocyte tyrosine kinase receptor(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 360nMAssay Description:Inhibition of LTK (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 379nMAssay Description:Inhibition of TrkB (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 379nMAssay Description:Inhibition of RET (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 391nMAssay Description:Inhibition of MEK2 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 408nMAssay Description:Inhibition of ABL (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 413nMAssay Description:Inhibition of ROCK1(unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 433nMAssay Description:Inhibition of JNK2 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 472nMAssay Description:Inhibition of AURKA (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 496nMAssay Description:Inhibition of JAK3 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 502nMAssay Description:Inhibition of INSR (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 513nMAssay Description:Inhibition of JNK1 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase TAO2(Homo sapiens (Human))
Abbvie Bioresearch Center
Curated by ChEMBL
Abbvie Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 529nMAssay Description:Inhibition of TAOK2 (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
