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Found 27 Enz. Inhib. hit(s) with all data for entry = 50040449
TargetSmoothened homolog(Mus musculus)
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50394403(CHEMBL2160074)
Affinity DataIC50:  0.100nMAssay Description:Antagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 1 nM Ag1.5-induced Gli expression incubated for 30 mins prior...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50394402(CHEMBL2160072)
Affinity DataIC50:  0.100nMAssay Description:Antagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 1 nM Ag1.5-induced Gli expression incubated for 30 mins prior...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50394407(CHEMBL2160077)
Affinity DataIC50:  0.100nMAssay Description:Antagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 1 nM Ag1.5-induced Gli expression incubated for 30 mins prior...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50394398(CHEMBL2160068)
Affinity DataIC50:  0.200nMAssay Description:Antagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 1 nM Ag1.5-induced Gli expression incubated for 30 mins prior...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50394395(CHEMBL2160078)
Affinity DataIC50:  0.200nMAssay Description:Antagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 1 nM Ag1.5-induced Gli expression incubated for 30 mins prior...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50394400(CHEMBL2160070)
Affinity DataIC50:  0.300nMAssay Description:Antagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 1 nM Ag1.5-induced Gli expression incubated for 30 mins prior...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50394401(CHEMBL2160071)
Affinity DataIC50:  0.400nMAssay Description:Antagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 1 nM Ag1.5-induced Gli expression incubated for 30 mins prior...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50394396(CHEMBL2160079)
Affinity DataIC50:  0.600nMAssay Description:Antagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 1 nM Ag1.5-induced Gli expression incubated for 30 mins prior...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50394405(CHEMBL2160076)
Affinity DataIC50:  0.600nMAssay Description:Antagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 1 nM Ag1.5-induced Gli expression incubated for 30 mins prior...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50394397(CHEMBL2160067)
Affinity DataIC50:  0.600nMAssay Description:Antagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 1 nM Ag1.5-induced Gli expression incubated for 30 mins prior...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50394397(CHEMBL2160067)
Affinity DataIC50:  1.60nMAssay Description:Antagonist activity at mouse Smo expressed in CHO cells assessed as inhibition of BODIPY-cyclopamine binding after 4 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50394403(CHEMBL2160074)
Affinity DataIC50:  1.60nMAssay Description:Antagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 25 nM Ag1.5-induced Gli expression incubated for 30 mins prio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50394404(CHEMBL2160073)
Affinity DataIC50:  2nMAssay Description:Antagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 1 nM Ag1.5-induced Gli expression incubated for 30 mins prior...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50394407(CHEMBL2160077)
Affinity DataIC50:  2.60nMAssay Description:Antagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 25 nM Ag1.5-induced Gli expression incubated for 30 mins prio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50394402(CHEMBL2160072)
Affinity DataIC50:  3nMAssay Description:Antagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 25 nM Ag1.5-induced Gli expression incubated for 30 mins prio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50249520(CHEMBL516246 | N-(4-chloro-3-(5-(dimethylamino)-1H...)
Affinity DataIC50:  3nMAssay Description:Antagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 1 nM Ag1.5-induced Gli expression incubated for 30 mins prior...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50394399(CHEMBL2160069)
Affinity DataIC50:  3nMAssay Description:Antagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 1 nM Ag1.5-induced Gli expression incubated for 30 mins prior...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50394397(CHEMBL2160067)
Affinity DataIC50:  4nMAssay Description:Antagonist activity at human Smo expressed in CHO cells assessed as inhibition of BODIPY-cyclopamine binding after 4 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50394400(CHEMBL2160070)
Affinity DataIC50:  5nMAssay Description:Antagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 25 nM Ag1.5-induced Gli expression incubated for 30 mins prio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50394398(CHEMBL2160068)
Affinity DataIC50:  6nMAssay Description:Antagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 25 nM Ag1.5-induced Gli expression incubated for 30 mins prio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50394401(CHEMBL2160071)
Affinity DataIC50:  8nMAssay Description:Antagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 25 nM Ag1.5-induced Gli expression incubated for 30 mins prio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50394397(CHEMBL2160067)
Affinity DataIC50:  11nMAssay Description:Antagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 25 nM Ag1.5-induced Gli expression incubated for 30 mins prio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50394405(CHEMBL2160076)
Affinity DataIC50:  12nMAssay Description:Antagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 25 nM Ag1.5-induced Gli expression incubated for 30 mins prio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50394406(CHEMBL2160075)
Affinity DataIC50:  19nMAssay Description:Antagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 1 nM Ag1.5-induced Gli expression incubated for 30 mins prior...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50394404(CHEMBL2160073)
Affinity DataIC50:  31nMAssay Description:Antagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 25 nM Ag1.5-induced Gli expression incubated for 30 mins prio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50394399(CHEMBL2160069)
Affinity DataIC50:  35nMAssay Description:Antagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 25 nM Ag1.5-induced Gli expression incubated for 30 mins prio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50394406(CHEMBL2160075)
Affinity DataIC50:  157nMAssay Description:Antagonist activity at Smo in mouse TM3 cells expressing Hh12 assessed as inhibition of 25 nM Ag1.5-induced Gli expression incubated for 30 mins prio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed