Compile Data Set for Download or QSAR
maximum 50k data
Found 24 Enz. Inhib. hit(s) with all data for entry = 50010808
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50542271(CHEMBL4639742)
Affinity DataKi:  0.900nMAssay Description:Inhibition of MDM2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50542270(CHEMBL4644415)
Affinity DataKi:  3nMAssay Description:Inhibition of MDM2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50441806(CHEMBL2436226 | US9422331, 32)
Affinity DataKi:  1.70E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50434287(CHEMBL2386346)
Affinity DataIC50:  18nMAssay Description:Inhibition of MDM2 (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50542269(CHEMBL4632870)
Affinity DataIC50:  39nMAssay Description:Inhibition of XIAP-BIR2 domain (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50441806(CHEMBL2436226 | US9422331, 32)
Affinity DataIC50:  45nMAssay Description:Inhibition of XIAP-BIR2 domain (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50542268(CHEMBL4635216)
Affinity DataIC50:  65nMAssay Description:Inhibition of XIAP-BIR2 domain (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50229787((4S,5R)-Nutlin-3 | (rac)-(4,5-bis(4-chlorophenyl)-...)
Affinity DataIC50:  88nMAssay Description:Inhibition of MDM2 (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50459944(CHEMBL4225537)
Affinity DataIC50:  88nMAssay Description:Inhibition of VHL (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50441342(CHEMBL2431765 | US9394263, 29)
Affinity DataIC50:  101nMAssay Description:Inhibition of XIAP-BIR2 domain (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50099062(CHEMBL3344081 | US10730870, Example 3 | US11512083...)
Affinity DataIC50:  185nMAssay Description:Inhibition of VHL (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50441347(CHEMBL2431760 | US9611224, Example 29)
Affinity DataIC50:  194nMAssay Description:Inhibition of XIAP-BIR2 domain (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50014097(CHEMBL3260851)
Affinity DataIC50:  670nMAssay Description:Inhibition of VHL (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetKelch-like ECH-associated protein 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50542274(CHEMBL4159561)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of KEAP1 interaction with Nrf2 (unknown origin) by SRP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKelch-like ECH-associated protein 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50542273(CHEMBL4159153)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of KEAP1 interaction with Nrf2 (unknown origin) by SRP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50542269(CHEMBL4632870)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibition of XIAP-BIR3 domain (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50446138(CHEMBL3108881)
Affinity DataIC50:  4.10E+3nMAssay Description:Inhibition of VHL (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50441806(CHEMBL2436226 | US9422331, 32)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50542268(CHEMBL4635216)
Affinity DataIC50:  2.40E+4nMAssay Description:Inhibition of XIAP-BIR3 domain (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50441806(CHEMBL2436226 | US9422331, 32)
Affinity DataIC50:  3.10E+4nMAssay Description:Inhibition of XIAP-BIR3 domain (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50441342(CHEMBL2431765 | US9394263, 29)
Affinity DataIC50: >5.40E+4nMAssay Description:Inhibition of XIAP-BIR3 domain (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50441347(CHEMBL2431760 | US9611224, Example 29)
Affinity DataIC50: >5.40E+4nMAssay Description:Inhibition of XIAP-BIR3 domain (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50542272(CHEMBL4639001)
Affinity DataIC50:  1.17E+5nMAssay Description:Inhibition of VHL (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetKelch-like ECH-associated protein 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50109398(CHEMBL2381968)
Affinity DataKd:  1.90E+3nMAssay Description:Binding affinity to KEAP1 interaction with Nrf2 (unknown origin) by SRP assayMore data for this Ligand-Target Pair