Compile Data Set for Download or QSAR
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Found 58 Enz. Inhib. hit(s) with all data for entry = 50017378
TargetTranslocator protein(Bos taurus)
Niddk

Curated by ChEMBL
LigandPNGBDBM50019213(1,3-dihydro-7-nitro-5-(2-chlorophenyl)-2H-1,4.benz...)
Affinity DataKi:  0.850nMAssay Description:Binding affinity to bovine brain membrane BzR assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTranslocator protein(Bos taurus)
Niddk

Curated by ChEMBL
LigandPNGBDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)
Affinity DataKi:  0.900nMAssay Description:Binding affinity to bovine brain membrane BzR assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCathepsin K(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50601464(CHEMBL5195850)
Affinity DataKi:  1.80nMAssay Description:Inhibition of human Cathepsin K assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Niddk

Curated by ChEMBL
LigandPNGBDBM50143225(CHEMBL300762 | N,N-Dibutyl-2-[5-chloro-2-(4-chloro...)
Affinity DataKi:  1.90nMAssay Description:Displacement of [3H]-PK11195 from rat kidney mitochondrial membrane TSPO receptor assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Niddk

Curated by ChEMBL
LigandPNGBDBM50601465(CHEMBL5204536)
Affinity DataKi:  5.5nMAssay Description:Displacement of [3H]-PK11195 from rat kidney mitochondrial membrane TSPO receptor assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Niddk

Curated by ChEMBL
LigandPNGBDBM50143238(2-[5-Chloro-2-(4-chloro-phenyl)-1H-indol-3-yl]-N,N...)
Affinity DataKi:  5.80nMAssay Description:Displacement of [3H]-PK11195 from rat kidney mitochondrial membrane TSPO receptor assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Niddk

Curated by ChEMBL
LigandPNGBDBM22032(1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoq...)
Affinity DataKi:  9.30nMAssay Description:Displacement of [3H]-PK11195 from rat kidney mitochondrial membrane TSPO receptor assessed as inhibition constantMore data for this Ligand-Target Pair
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50258312(CHEMBL4095528)
Affinity DataKi:  18nMAssay Description:Inhibition of Calpain I (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Niddk

Curated by ChEMBL
LigandPNGBDBM22040(4 -chlorodiazepam | 4' Cl-diazepam | 7-chloro-...)
Affinity DataKi:  23nMAssay Description:Binding affinity rat kidney mitochondrial membrane TSPO receptor assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCathepsin B(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50601464(CHEMBL5195850)
Affinity DataKi:  28nMAssay Description:Inhibition of human Cathepsin B assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50258383(CHEMBL4063636)
Affinity DataKi:  34nMAssay Description:Inhibition of Calpain I (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50601464(CHEMBL5195850)
Affinity DataKi:  56nMAssay Description:Inhibition of human Calpain I assessed as dissociation constant using Suc-Leu-Tyr-AMC as substrate preincubated for 15 mins followed by compound addi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTranslocator protein(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50601468(CHEMBL5179024)
Affinity DataKi:  108nMAssay Description:Displacement of [3H] PK11195 from TSPO in human U-87 MGcell membrane assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTranslocator protein(Bos taurus)
Niddk

Curated by ChEMBL
LigandPNGBDBM50055261(CHEMBL75307 | N-Benzyl-2-(5-nitro-1H-indol-3-yl)-2...)
Affinity DataKi:  117nMAssay Description:Binding affinity to bovine brain membrane BzR assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProcathepsin L(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50601464(CHEMBL5195850)
Affinity DataKi:  137nMAssay Description:Inhibition of human Cathepsin L assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTranslocator protein(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50601467(CHEMBL5169788)
Affinity DataKi:  202nMAssay Description:Displacement of [3H] PK11195 from TSPO (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTranslocator protein(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50601466(CHEMBL5172740)
Affinity DataKi:  438nMAssay Description:Displacement of [3H] PK11195 from TSPO (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCathepsin S(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50601464(CHEMBL5195850)
Affinity DataKi:  3.29E+3nMAssay Description:Inhibition of human Cathepsin S assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50601469(CHEMBL5172164)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of human group IIA phospholipase A2 preincubated with compound for 10 mins followed by enzyme addition and measured after 30 mins by PC/DO...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50053137((1-Aminooxalyl-3-biphenyl-2-ylmethyl-2-ethyl-indol...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human group IIA phospholipase A2 preincubated with compound for 10 mins followed by enzyme addition and measured after 30 mins by PC/DO...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50601472(CHEMBL5208632)
Affinity DataIC50:  5nMAssay Description:Inhibition of human group IIA phospholipase A2 preincubated with compound for 10 mins followed by enzyme addition and measured after 30 mins by PC/DO...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50055371((3-aminooxalyl-1-biphenyl-2-ylmethyl-2-methyl-1H-i...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human group IIA phospholipase A2 incubated for 1 hrs by scintillation counter analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50053137((1-Aminooxalyl-3-biphenyl-2-ylmethyl-2-ethyl-indol...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human group IIA phospholipase A2 incubated for 30 mins by automatic plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50601468(CHEMBL5179024)
Affinity DataIC50:  6.80nMAssay Description:Inhibition of MDM2 in human U-87 MG cells incubated for 15 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50601470(CHEMBL5177527)
Affinity DataIC50:  7nMAssay Description:Inhibition of human group IIA phospholipase A2 incubated for 30 mins by automatic plate reader analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50601470(CHEMBL5177527)
Affinity DataIC50:  7nMAssay Description:Inhibition of human group IIA phospholipase A2 preincubated with compound for 10 mins followed by enzyme addition and measured after 30 mins by PC/DO...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhospholipase A2, major isoenzyme(Sus scrofa (pig))
Niddk

Curated by ChEMBL
LigandPNGBDBM50055384((3-Aminooxalyl-1-biphenyl-3-ylmethyl-2-methyl-1H-i...)
Affinity DataIC50:  7nMAssay Description:Inhibition of pig group IB phospholipase A2 incubated for 1 hrs by scintillation counter analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50601469(CHEMBL5172164)
Affinity DataIC50:  8nMAssay Description:Inhibition of human group IIA phospholipase A2 incubated for 30 mins by automatic plate reader analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50055366((3-Aminooxalyl-1-benzyl-2-ethyl-1H-indol-4-yloxy)-...)
Affinity DataIC50:  9nMAssay Description:Inhibition of human group IIA phospholipase A2 incubated for 1 hrs by scintillation counter analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50055384((3-Aminooxalyl-1-biphenyl-3-ylmethyl-2-methyl-1H-i...)
Affinity DataIC50:  9nMAssay Description:Inhibition of human group IIA phospholipase A2 incubated for 1 hrs by scintillation counter analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGroup IIE secretory phospholipase A2(Mus musculus)
Niddk

Curated by ChEMBL
LigandPNGBDBM50601469(CHEMBL5172164)
Affinity DataIC50:  10nMAssay Description:Inhibition of mouse group IIE phospholipase A2 incubated for 10 to 20 mins cells by radiometric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhospholipase A2 group V(Mus musculus)
Niddk

Curated by ChEMBL
LigandPNGBDBM50601469(CHEMBL5172164)
Affinity DataIC50:  10nMAssay Description:Inhibition of mouse group V phospholipase A2 incubated for 10 to 20 mins cells by radiometric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhospholipase A2 group V(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50601469(CHEMBL5172164)
Affinity DataIC50:  10nMAssay Description:Inhibition of human group V phospholipase A2 expressed in Escherichia coli BL21(DE3) cells incubated for 10 to 20 mins cells by radiometric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGroup IIE secretory phospholipase A2(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50601469(CHEMBL5172164)
Affinity DataIC50:  10nMAssay Description:Inhibition of human group IIE phospholipase A2 expressed in Escherichia coli BL21 cells incubated for 10 to 20 mins cells by radiometric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhospholipase A2, membrane associated(Mus musculus)
Niddk

Curated by ChEMBL
LigandPNGBDBM50601469(CHEMBL5172164)
Affinity DataIC50:  10nMAssay Description:Inhibition of mouse group IIA phospholipase A2 incubated for 10 to 20 mins cells by radiometric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50601469(CHEMBL5172164)
Affinity DataIC50:  10nMAssay Description:Inhibition of human group IIA phospholipase A2 incubated for 10 to 20 mins cells by radiometric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGroup IIC secretory phospholipase A2(Mus musculus)
Niddk

Curated by ChEMBL
LigandPNGBDBM50601469(CHEMBL5172164)
Affinity DataIC50:  10nMAssay Description:Inhibition of mouse group IIC phospholipase A2 incubated for 10 to 20 mins cells by radiometric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50055383((3-Aminooxalyl-1-benzyl-2-methyl-1H-indol-4-yloxy)...)
Affinity DataIC50:  11nMAssay Description:Inhibition of human group IIA phospholipase A2 incubated for 1 hrs by scintillation counter analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50601466(CHEMBL5172740)
Affinity DataIC50:  12nMAssay Description:Inhibition of MDM2 (unknown origin) by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhospholipase A2, major isoenzyme(Sus scrofa (pig))
Niddk

Curated by ChEMBL
LigandPNGBDBM50055383((3-Aminooxalyl-1-benzyl-2-methyl-1H-indol-4-yloxy)...)
Affinity DataIC50:  15nMAssay Description:Inhibition of pig group IB phospholipase A2 incubated for 1 hrs by scintillation counter analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50601472(CHEMBL5208632)
Affinity DataIC50:  30nMAssay Description:Inhibition of human group IIA phospholipase A2 incubated for 30 mins by automatic plate reader analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhospholipase A2, major isoenzyme(Sus scrofa (pig))
Niddk

Curated by ChEMBL
LigandPNGBDBM50055366((3-Aminooxalyl-1-benzyl-2-ethyl-1H-indol-4-yloxy)-...)
Affinity DataIC50:  48nMAssay Description:Inhibition of pig group IB phospholipase A2 incubated for 1 hrs by scintillation counter analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPhospholipase A2, major isoenzyme(Sus scrofa (pig))
Niddk

Curated by ChEMBL
LigandPNGBDBM50055371((3-aminooxalyl-1-biphenyl-2-ylmethyl-2-methyl-1H-i...)
Affinity DataIC50:  97nMAssay Description:Inhibition of pig group IB phospholipase A2 incubated for 1 hrs by scintillation counter analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGroup 10 secretory phospholipase A2(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50601469(CHEMBL5172164)
Affinity DataIC50:  100nMAssay Description:Inhibition of human group X phospholipase A2 incubated for 10 to 20 mins cells by radiometric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGroup 10 secretory phospholipase A2(Mus musculus)
Niddk

Curated by ChEMBL
LigandPNGBDBM50601469(CHEMBL5172164)
Affinity DataIC50:  100nMAssay Description:Inhibition of mouse group X phospholipase A2 incubated for 10 to 20 mins cells by radiometric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhospholipase A2(Mus musculus)
Niddk

Curated by ChEMBL
LigandPNGBDBM50601469(CHEMBL5172164)
Affinity DataIC50:  100nMAssay Description:Inhibition of mouse group IB phospholipase A2 incubated for 10 to 20 mins cells by radiometric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhospholipase A2(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50601469(CHEMBL5172164)
Affinity DataIC50:  100nMAssay Description:Inhibition of human group IB phospholipase A2 expressed in Escherichia coli BL21 cells incubated for 10 to 20 mins cells by radiometric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50601467(CHEMBL5169788)
Affinity DataIC50:  202nMAssay Description:Inhibition of MDM2 (unknown origin) by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhospholipase A2(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50055366((3-Aminooxalyl-1-benzyl-2-ethyl-1H-indol-4-yloxy)-...)
Affinity DataIC50:  228nMAssay Description:Inhibition of human group IB phospholipase A2 incubated for 1 hrs by scintillation counter analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPhospholipase A2(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM50055371((3-aminooxalyl-1-biphenyl-2-ylmethyl-2-methyl-1H-i...)
Affinity DataIC50:  364nMAssay Description:Inhibition of human group IB phospholipase A2 incubated for 1 hrs by scintillation counter analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
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