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Report error Found 3 Enz. Inhib. hit(s) with all data for assayid = 4 entry = 50012504
TargetALK tyrosine kinase receptor(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM243402(5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(6-me...)
Affinity DataIC50:  0.240nMAssay Description:Inhibition of crizotinib-resistant ALK G1269A mutant (unknown origin) using peptide substrate incubated for 30 mins in presence of ATP by fluorescenc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM243370(5-chloro-N4-(2-(isopropylsulfonyl)phenyl-N2-(7-met...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of crizotinib-resistant ALK G1269A mutant (unknown origin) using peptide substrate incubated for 30 mins in presence of ATP by fluorescenc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Human)
Korea Research Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50436850(CERITINIB | CHEMBL2403108 | LDK378 | US10053458, C...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of crizotinib-resistant ALK G1269A mutant (unknown origin) using peptide substrate incubated for 30 mins in presence of ATP by fluorescenc...More data for this Ligand-Target Pair