Compile Data Set for Download or QSAR
maximum 50k data
Found 43
TargetcAMP-dependent protein kinase catalytic subunit alpha(Mus musculus (mouse))
Vertex Pharmaceuticals

LigandPNGBDBM14028((S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]...)
Affinity DataKi:  340nM ΔG°:  -37.5kJ/molepH: 7.6 T: 2°CAssay Description:The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Mus musculus (mouse))
Vertex Pharmaceuticals

LigandPNGBDBM14027(5-(1,4-diazepan-1-ylsulfonyl)isoquinoline | 5-(1,4...)
Affinity DataKi:  460nM ΔG°:  -36.8kJ/molepH: 7.6 T: 2°CAssay Description:The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Mus musculus (mouse))
Vertex Pharmaceuticals

LigandPNGBDBM14031(5-(1,4-diazepane-1-sulfonyl)-1,2-dihydroisoquinoli...)
Affinity DataKi:  2.20E+3nM ΔG°:  -32.8kJ/molepH: 7.6 T: 2°CAssay Description:The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Mus musculus (mouse))
Vertex Pharmaceuticals

LigandPNGBDBM14029((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
Affinity DataKi: >5.00E+3nM ΔG°: >-30.8kJ/molepH: 7.6 T: 2°CAssay Description:The enzyme activity was assayed by using an ATP regenerative NADH consuming system. The reaction was started with adding ATP to the mixture containin...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Mus musculus (mouse))
Vertex Pharmaceuticals

LigandPNGBDBM27250(6-{[(1S,3R,4R)-3-(6-amino-9H-purin-9-yl)-4-hydroxy...)
Affinity DataIC50:  2.41nMAssay Description:The IC50 values of the inhibitors corresponding to the concentration of the inhibitor decreasing the enzyme activity 50% were measured using fluoresc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Mus musculus (mouse))
Vertex Pharmaceuticals

LigandPNGBDBM27249(ARC-903 | N-[(1R)-4-carbamimidamido-1-{[(1R)-4-car...)
Affinity DataIC50:  5.30nMAssay Description:The IC50 values of the inhibitors corresponding to the concentration of the inhibitor decreasing the enzyme activity 50% were measured using fluoresc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Mus musculus (mouse))
Vertex Pharmaceuticals

LigandPNGBDBM27227((2R)-6-amino-2-(6-{[(2S,3S,4R,5R)-5-(6-amino-9H-pu...)
Affinity DataIC50:  5.32nMAssay Description:The IC50 values of the inhibitors corresponding to the concentration of the inhibitor decreasing the enzyme activity 50% were measured using fluoresc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Mus musculus (mouse))
Vertex Pharmaceuticals

LigandPNGBDBM27248(6-{[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-di...)
Affinity DataIC50:  8.30nMAssay Description:The IC50 values of the inhibitors corresponding to the concentration of the inhibitor decreasing the enzyme activity 50% were measured using fluoresc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Mus musculus (mouse))
Vertex Pharmaceuticals

LigandPNGBDBM27226((2R)-6-amino-2-(6-{[(2S,3S,4R,5R)-5-(6-amino-9H-pu...)
Affinity DataIC50:  13.4nMAssay Description:The IC50 values of the inhibitors corresponding to the concentration of the inhibitor decreasing the enzyme activity 50% were measured using fluoresc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Mus musculus (mouse))
Vertex Pharmaceuticals

LigandPNGBDBM27229(6-{[(1S,3R,4R)-3-(6-amino-9H-purin-9-yl)-4-hydroxy...)
Affinity DataIC50:  21.1nMAssay Description:The IC50 values of the inhibitors corresponding to the concentration of the inhibitor decreasing the enzyme activity 50% were measured using fluoresc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Mus musculus (mouse))
Vertex Pharmaceuticals

LigandPNGBDBM27225((2R)-6-amino-2-(6-{[(2S,3S,4R,5R)-5-(6-amino-9H-pu...)
Affinity DataIC50:  54nMAssay Description:The IC50 values of the inhibitors corresponding to the concentration of the inhibitor decreasing the enzyme activity 50% were measured using fluoresc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetcAMP-dependent protein kinase catalytic subunit alpha(Mus musculus (mouse))
Vertex Pharmaceuticals

LigandPNGBDBM27228(6-{[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-di...)
Affinity DataIC50:  97nMAssay Description:The IC50 values of the inhibitors corresponding to the concentration of the inhibitor decreasing the enzyme activity 50% were measured using fluoresc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetcAMP-dependent protein kinase catalytic subunit alpha(Mus musculus (mouse))
Vertex Pharmaceuticals

LigandPNGBDBM15211(CHEMBL104264 | H-89 | H89 | HT-89 (H-89) | N-(2-{[...)
Affinity DataIC50:  100nMAssay Description:The IC50 values of the inhibitors corresponding to the concentration of the inhibitor decreasing the enzyme activity 50% were measured using fluoresc...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Mus musculus (mouse))
Vertex Pharmaceuticals

LigandPNGBDBM27224(6-{[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-di...)
Affinity DataIC50:  2.10E+3nMAssay Description:The IC50 values of the inhibitors corresponding to the concentration of the inhibitor decreasing the enzyme activity 50% were measured using fluoresc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Mus musculus (mouse))
Vertex Pharmaceuticals

LigandPNGBDBM27222(6-{[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-di...)
Affinity DataIC50:  2.60E+3nMAssay Description:The IC50 values of the inhibitors corresponding to the concentration of the inhibitor decreasing the enzyme activity 50% were measured using fluoresc...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Mus musculus (mouse))
Vertex Pharmaceuticals

LigandPNGBDBM27223(6-{[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-di...)
Affinity DataIC50:  2.60E+4nMAssay Description:The IC50 values of the inhibitors corresponding to the concentration of the inhibitor decreasing the enzyme activity 50% were measured using fluoresc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Mus musculus (mouse))
Vertex Pharmaceuticals

LigandPNGBDBM27233((2R)-6-amino-2-(6-{[(2S,3S,4R,5R)-5-(6-amino-9H-pu...)
Affinity DataKd:  443nMpH: 7.5 T: 2°CAssay Description:The assay is based on the kinase-bound labeled fluorescent probe can be displaced by competitive inhibitors, which can be registered by measurement o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Mus musculus (mouse))
Vertex Pharmaceuticals

LigandPNGBDBM27234(6-{[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-di...)
Affinity DataKd:  8.23E+3nMpH: 7.5 T: 2°CAssay Description:The assay is based on the kinase-bound labeled fluorescent probe can be displaced by competitive inhibitors, which can be registered by measurement o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Mus musculus (mouse))
Vertex Pharmaceuticals

LigandPNGBDBM27235(6-{[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-di...)
Affinity DataKd:  6.05E+3nMpH: 7.5 T: 2°CAssay Description:The assay is based on the kinase-bound labeled fluorescent probe can be displaced by competitive inhibitors, which can be registered by measurement o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Mus musculus (mouse))
Vertex Pharmaceuticals

LigandPNGBDBM27236(6-{[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-di...)
Affinity DataKd:  1.64E+3nMpH: 7.5 T: 2°CAssay Description:The assay is based on the kinase-bound labeled fluorescent probe can be displaced by competitive inhibitors, which can be registered by measurement o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Mus musculus (mouse))
Vertex Pharmaceuticals

LigandPNGBDBM27237(6-{[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-di...)
Affinity DataKd:  1.87E+4nMpH: 7.5 T: 2°CAssay Description:The assay is based on the kinase-bound labeled fluorescent probe can be displaced by competitive inhibitors, which can be registered by measurement o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Mus musculus (mouse))
Vertex Pharmaceuticals

LigandPNGBDBM27238(6-{[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-di...)
Affinity DataKd:  1.35E+4nMpH: 7.5 T: 2°CAssay Description:The assay is based on the kinase-bound labeled fluorescent probe can be displaced by competitive inhibitors, which can be registered by measurement o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Mus musculus (mouse))
Vertex Pharmaceuticals

LigandPNGBDBM27239(6-{[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-di...)
Affinity DataKd: >1.00E+5nMpH: 7.5 T: 2°CAssay Description:The assay is based on the kinase-bound labeled fluorescent probe can be displaced by competitive inhibitors, which can be registered by measurement o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Mus musculus (mouse))
Vertex Pharmaceuticals

LigandPNGBDBM27240(6-{[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-di...)
Affinity DataKd:  1.96E+3nMpH: 7.5 T: 2°CAssay Description:The assay is based on the kinase-bound labeled fluorescent probe can be displaced by competitive inhibitors, which can be registered by measurement o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Mus musculus (mouse))
Vertex Pharmaceuticals

LigandPNGBDBM27241((2R)-6-amino-2-(6-{[(2S,3S,4R,5R)-5-(6-amino-9H-pu...)
Affinity DataKd:  12.6nMpH: 7.5 T: 2°CAssay Description:The assay is based on the kinase-bound labeled fluorescent probe can be displaced by competitive inhibitors, which can be registered by measurement o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Mus musculus (mouse))
Vertex Pharmaceuticals

LigandPNGBDBM27242(8-[(2R)-6-amino-2-(6-{[(2S,3S,4R,5R)-5-(6-amino-9H...)
Affinity DataKd:  9.5nMpH: 7.5 T: 2°CAssay Description:The assay is based on the kinase-bound labeled fluorescent probe can be displaced by competitive inhibitors, which can be registered by measurement o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Mus musculus (mouse))
Vertex Pharmaceuticals

LigandPNGBDBM27243(6-(6-{[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4...)
Affinity DataKd:  83nMpH: 7.5 T: 2°CAssay Description:The assay is based on the kinase-bound labeled fluorescent probe can be displaced by competitive inhibitors, which can be registered by measurement o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Mus musculus (mouse))
Vertex Pharmaceuticals

LigandPNGBDBM27244(6-{[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-di...)
Affinity DataKd:  247nMpH: 7.5 T: 2°CAssay Description:The assay is based on the kinase-bound labeled fluorescent probe can be displaced by competitive inhibitors, which can be registered by measurement o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Mus musculus (mouse))
Vertex Pharmaceuticals

LigandPNGBDBM27245(8-(6-{[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4...)
Affinity DataKd:  95.4nMpH: 7.5 T: 2°CAssay Description:The assay is based on the kinase-bound labeled fluorescent probe can be displaced by competitive inhibitors, which can be registered by measurement o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Mus musculus (mouse))
Vertex Pharmaceuticals

LigandPNGBDBM27246((2R)-6-amino-2-(6-{[(2S,3S,4R,5R)-5-(6-amino-9H-pu...)
Affinity DataKd:  8.70nMpH: 7.5 T: 2°CAssay Description:The assay is based on the kinase-bound labeled fluorescent probe can be displaced by competitive inhibitors, which can be registered by measurement o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Mus musculus (mouse))
Vertex Pharmaceuticals

LigandPNGBDBM27247((2S)-6-amino-2-(6-{[(2S,3S,4R,5R)-5-(6-amino-9H-pu...)
Affinity DataKd:  594nMpH: 7.5 T: 2°CAssay Description:The assay is based on the kinase-bound labeled fluorescent probe can be displaced by competitive inhibitors, which can be registered by measurement o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Mus musculus (mouse))
Vertex Pharmaceuticals

LigandPNGBDBM27227((2R)-6-amino-2-(6-{[(2S,3S,4R,5R)-5-(6-amino-9H-pu...)
Affinity DataKd: <0.5nMpH: 7.5 T: 2°CAssay Description:The assay is based on the kinase-bound labeled fluorescent probe can be displaced by competitive inhibitors, which can be registered by measurement o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Mus musculus (mouse))
Vertex Pharmaceuticals

LigandPNGBDBM27226((2R)-6-amino-2-(6-{[(2S,3S,4R,5R)-5-(6-amino-9H-pu...)
Affinity DataKd:  0.5nMpH: 7.5 T: 2°CAssay Description:The assay is based on the kinase-bound labeled fluorescent probe can be displaced by competitive inhibitors, which can be registered by measurement o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Mus musculus (mouse))
Vertex Pharmaceuticals

LigandPNGBDBM27225((2R)-6-amino-2-(6-{[(2S,3S,4R,5R)-5-(6-amino-9H-pu...)
Affinity DataKd:  7.60nMpH: 7.5 T: 2°CAssay Description:The assay is based on the kinase-bound labeled fluorescent probe can be displaced by competitive inhibitors, which can be registered by measurement o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetcAMP-dependent protein kinase catalytic subunit alpha(Mus musculus (mouse))
Vertex Pharmaceuticals

LigandPNGBDBM27224(6-{[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-di...)
Affinity DataKd:  249nMpH: 7.5 T: 2°CAssay Description:The assay is based on the kinase-bound labeled fluorescent probe can be displaced by competitive inhibitors, which can be registered by measurement o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Mus musculus (mouse))
Vertex Pharmaceuticals

LigandPNGBDBM27223(6-{[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-di...)
Affinity DataKd:  2.18E+3nMpH: 7.5 T: 2°CAssay Description:The assay is based on the kinase-bound labeled fluorescent probe can be displaced by competitive inhibitors, which can be registered by measurement o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Mus musculus (mouse))
Vertex Pharmaceuticals

LigandPNGBDBM27222(6-{[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-di...)
Affinity DataKd:  319nMpH: 7.5 T: 2°CAssay Description:The assay is based on the kinase-bound labeled fluorescent probe can be displaced by competitive inhibitors, which can be registered by measurement o...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Mus musculus (mouse))
Vertex Pharmaceuticals

LigandPNGBDBM15211(CHEMBL104264 | H-89 | H89 | HT-89 (H-89) | N-(2-{[...)
Affinity DataKd:  23nMpH: 7.5 T: 2°CAssay Description:The assay is based on the kinase-bound labeled fluorescent probe can be displaced by competitive inhibitors, which can be registered by measurement o...More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Mus musculus (mouse))
Vertex Pharmaceuticals

LigandPNGBDBM27232(ARC-1056, 5 | [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9...)
Affinity DataKd:  5.21E+4nMpH: 7.5 T: 2°CAssay Description:The assay is based on the kinase-bound labeled fluorescent probe can be displaced by competitive inhibitors, which can be registered by measurement o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Mus musculus (mouse))
Vertex Pharmaceuticals

LigandPNGBDBM27231(ARC-1003, 4 | [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9...)
Affinity DataKd:  9.87E+4nMpH: 7.5 T: 2°CAssay Description:The assay is based on the kinase-bound labeled fluorescent probe can be displaced by competitive inhibitors, which can be registered by measurement o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Mus musculus (mouse))
Vertex Pharmaceuticals

LigandPNGBDBM27228(6-{[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-di...)
Affinity DataKd:  5.80nMpH: 7.5 T: 2°CAssay Description:The assay is based on the kinase-bound labeled fluorescent probe can be displaced by competitive inhibitors, which can be registered by measurement o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetcAMP-dependent protein kinase catalytic subunit alpha(Mus musculus (mouse))
Vertex Pharmaceuticals

LigandPNGBDBM27229(6-{[(1S,3R,4R)-3-(6-amino-9H-purin-9-yl)-4-hydroxy...)
Affinity DataKd:  1.80nMpH: 7.5 T: 2°CAssay Description:The assay is based on the kinase-bound labeled fluorescent probe can be displaced by competitive inhibitors, which can be registered by measurement o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Mus musculus (mouse))
Vertex Pharmaceuticals

LigandPNGBDBM27230(6-{[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-di...)
Affinity DataKd:  5.58E+4nMpH: 7.5 T: 2°CAssay Description:The assay is based on the kinase-bound labeled fluorescent probe can be displaced by competitive inhibitors, which can be registered by measurement o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed