TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Affinity DataKi: 27nMAssay Description:Binding affinity to pregnane receptor in human hepatocytesMore data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Affinity DataKi: 27nMAssay Description:Displacement of [3H]SR12813 from human PXR by scintillation proximity competition binding assayMore data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Affinity DataKi: 2.00E+3nMAssay Description:Binding affinity to PXR by scintillation proximity binding assayMore data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to PXR by scintillation proximity binding assayMore data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to PXR by scintillation proximity binding assayMore data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inverse agonist activity at human PXR in human HepG2 cells co-expressing luciferase gene under control of CYP3A4 promoter assessed as inhibition of r...More data for this Ligand-Target Pair
Ligand Info
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Affinity DataIC50: 1.60nMAssay Description:Inverse agonist activity at human PXR in human HepG2 cells co-expressing luciferase gene under control of CYP3A4 promoter assessed as inhibition of r...More data for this Ligand-Target Pair
Ligand Info
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Affinity DataIC50: 2.40nMAssay Description:Inhibitory concentration against Pregnane X receptorMore data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Affinity DataIC50: 2.40nMAssay Description:Inhibitory concentration against Pregnane X receptorMore data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of BODIPY FL vindoline binding to recombinant human GST-tagged PXR LBD (111 to 434 residues) expressed in baculovirus infected insect cell...More data for this Ligand-Target Pair
Ligand Info
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of BODIPY FL vindoline binding to recombinant human GST-tagged PXR LBD (111 to 434 residues) expressed in baculovirus infected insect cell...More data for this Ligand-Target Pair
Ligand Info
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Affinity DataIC50: 6.90nMAssay Description:Antagonist activity at human PXR in human HepG2 cells co-expressing luciferase gene under control of CYP3A4 promoter assessed as inhibition in rifamp...More data for this Ligand-Target Pair
Ligand Info
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Affinity DataIC50: 6.90nMAssay Description:Inverse agonist activity at human PXR in human HepG2 cells co-expressing luciferase gene under control of CYP3A4 promoter assessed as inhibition of r...More data for this Ligand-Target Pair
Ligand Info
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of BODIPY FL vindoline binding to recombinant human GST-tagged PXR LBD (111 to 434 residues) expressed in baculovirus infected insect cell...More data for this Ligand-Target Pair
Ligand Info
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of BODIPY FL vindoline binding to recombinant human GST-tagged PXR LBD (111 to 434 residues) expressed in baculovirus infected insect cell...More data for this Ligand-Target Pair
Ligand Info
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:Antagonist activity at human PXR in human HepG2 cells co-expressing luciferase gene under control of CYP3A4 promoter assessed as inhibition in rifamp...More data for this Ligand-Target Pair
Ligand Info
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:The time-resolved fluorescence resonance transfer (TR-FRET) hPXR competitive binding assay was performed according to the manufacturer's instruct...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:The time-resolved fluorescence resonance transfer (TR-FRET) hPXR competitive binding assay was performed according to the manufacturer's instruct...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:The time-resolved fluorescence resonance transfer (TR-FRET) hPXR competitive binding assay was performed according to the manufacturer's instruct...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:The time-resolved fluorescence resonance transfer (TR-FRET) hPXR competitive binding assay was performed according to the manufacturer's instruct...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:The time-resolved fluorescence resonance transfer (TR-FRET) hPXR competitive binding assay was performed according to the manufacturer's instruct...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:The time-resolved fluorescence resonance transfer (TR-FRET) hPXR competitive binding assay was performed according to the manufacturer's instruct...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:The time-resolved fluorescence resonance transfer (TR-FRET) hPXR competitive binding assay was performed according to the manufacturer's instruct...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:The time-resolved fluorescence resonance transfer (TR-FRET) hPXR competitive binding assay was performed according to the manufacturer's instruct...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:The time-resolved fluorescence resonance transfer (TR-FRET) hPXR competitive binding assay was performed according to the manufacturer's instruct...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:The time-resolved fluorescence resonance transfer (TR-FRET) hPXR competitive binding assay was performed according to the manufacturer's instruct...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of BODIPY FL vindoline binding to recombinant human GST-tagged PXR LBD (111 to 434 residues) expressed in baculovirus infected insect cell...More data for this Ligand-Target Pair
Ligand Info
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of BODIPY FL vindoline binding to recombinant human GST-tagged PXR LBD (111 to 434 residues) expressed in baculovirus infected insect cell...More data for this Ligand-Target Pair
Ligand Info
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Affinity DataIC50: 12.3nMAssay Description:The time-resolved fluorescence resonance transfer (TR-FRET) hPXR competitive binding assay was performed according to the manufacturer's instruct...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Affinity DataIC50: 12.3nMAssay Description:The time-resolved fluorescence resonance transfer (TR-FRET) hPXR competitive binding assay was performed according to the manufacturer's instruct...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inverse agonist activity at human PXR in human HepG2 cells co-expressing luciferase gene under control of CYP3A4 promoter assessed as inhibition of r...More data for this Ligand-Target Pair
Ligand Info
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Antagonist activity at human PXR in human HepG2 cells co-expressing luciferase gene under control of CYP3A4 promoter assessed as inhibition in rifamp...More data for this Ligand-Target Pair
Ligand Info
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Antagonist activity at human PXR in human HepG2 cells co-expressing luciferase gene under control of CYP3A4 promoter assessed as inhibition in rifamp...More data for this Ligand-Target Pair
Ligand Info
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of BODIPY FL vindoline binding to recombinant human GST-tagged PXR LBD (111 to 434 residues) expressed in baculovirus infected insect cell...More data for this Ligand-Target Pair
Ligand Info
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inverse agonist activity at human PXR in human HepG2 cells co-expressing luciferase gene under control of CYP3A4 promoter assessed as inhibition of r...More data for this Ligand-Target Pair
Ligand Info
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inverse agonist activity at human PXR in human HepG2 cells co-expressing luciferase gene under control of CYP3A4 promoter assessed as inhibition of r...More data for this Ligand-Target Pair
Ligand Info
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of BODIPY FL vindoline binding to recombinant human GST-tagged PXR LBD (111 to 434 residues) expressed in baculovirus infected insect cell...More data for this Ligand-Target Pair
Ligand Info
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Antagonist activity at human PXR in human HepG2 cells co-expressing luciferase gene under control of CYP3A4 promoter assessed as inhibition in rifamp...More data for this Ligand-Target Pair
Ligand Info
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of BODIPY FL vindoline binding to recombinant human GST-tagged PXR LBD (111 to 434 residues) expressed in baculovirus infected insect cell...More data for this Ligand-Target Pair
Ligand Info
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of BODIPY FL vindoline binding to recombinant human GST-tagged PXR LBD (111 to 434 residues) expressed in baculovirus infected insect cell...More data for this Ligand-Target Pair
Ligand Info
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Inhibition of BODIPY FL vindoline binding to recombinant human GST-tagged PXR LBD (111 to 434 residues) expressed in baculovirus infected insect cell...More data for this Ligand-Target Pair
Ligand Info
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Antagonist activity at human PXR in human HepG2 cells co-expressing luciferase gene under control of CYP3A4 promoter assessed as inhibition in rifamp...More data for this Ligand-Target Pair
Ligand Info
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:The time-resolved fluorescence resonance transfer (TR-FRET) hPXR competitive binding assay was performed according to the manufacturer's instruct...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:The time-resolved fluorescence resonance transfer (TR-FRET) hPXR competitive binding assay was performed according to the manufacturer's instruct...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:The time-resolved fluorescence resonance transfer (TR-FRET) hPXR competitive binding assay was performed according to the manufacturer's instruct...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:The time-resolved fluorescence resonance transfer (TR-FRET) hPXR competitive binding assay was performed according to the manufacturer's instruct...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Affinity DataIC50: 20nM EC50: 10nMpH: 8.0 T: 2°CAssay Description:Polylysine YiO imaging beads (Amersham, GE Healthcare) were coated with histidine-tagged WT PXR LBD. Nonspecific binding sites were blocked with BSA....More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of BODIPY FL vindoline binding to recombinant human GST-tagged PXR LBD (111 to 434 residues) expressed in baculovirus infected insect cell...More data for this Ligand-Target Pair
Ligand Info
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:The time-resolved fluorescence resonance transfer (TR-FRET) hPXR competitive binding assay was performed according to the manufacturer's instruct...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Westfalische Wilhelms-Universitat
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:The time-resolved fluorescence resonance transfer (TR-FRET) hPXR competitive binding assay was performed according to the manufacturer's instruct...More data for this Ligand-Target Pair