Compile Data Set for Download or QSAR
Found 1463 Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK2 [828-1132]'
TargetTyrosine-protein kinase JAK2 [828-1132](Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM197716(US9216984, 1)
Show SMILES CCCCCC(CC#N)n1cc(cn1)-c1ncnc2[nH]ccc12
Affinity DataIC50: 0.260nMpH: 7.8 T: 2°CAssay Description:The compounds of the invention were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al.,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2 [828-1132](Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM197716(US9216984, 1)
Show SMILES CCCCCC(CC#N)n1cc(cn1)-c1ncnc2[nH]ccc12
Affinity DataIC50: 0.290nMpH: 7.8 T: 2°CAssay Description:The compounds of the invention were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al.,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2 [828-1132](Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM197717(US9216984, 2)
Show SMILES CCCCC(CC#N)n1cc(cn1)-c1ncnc2[nH]ccc12
Affinity DataIC50: 0.300nMpH: 7.8 T: 2°CAssay Description:The compounds of the invention were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al.,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2 [828-1132](Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM197717(US9216984, 2)
Show SMILES CCCCC(CC#N)n1cc(cn1)-c1ncnc2[nH]ccc12
Affinity DataIC50: 0.650nMpH: 7.8 T: 2°CAssay Description:The compounds of the invention were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al.,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2 [828-1132](Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM197717(US9216984, 2)
Show SMILES CCCCC(CC#N)n1cc(cn1)-c1ncnc2[nH]ccc12
Affinity DataIC50: 1.40nMpH: 7.8 T: 2°CAssay Description:The compounds of the invention were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al.,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2 [828-1132](Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM197716(US9216984, 1)
Show SMILES CCCCCC(CC#N)n1cc(cn1)-c1ncnc2[nH]ccc12
Affinity DataIC50: 2.20nMpH: 7.8 T: 2°CAssay Description:The compounds of the invention were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al.,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2 [828-1132](Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM400270(US10695337, Example 25 | US11285140, Example 25 | ...)
Show SMILES Fc1cccc(c1)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C26H25FN8O/c27-20-3-1-2-18(12-20)25(36)33-10-5-21(6-11-33)34-15-26(16-34,7-8-28)35-14-19(13-32-35)23-22-4-9-29-24(22)31-17-30-23/h1-4,9,12-14,17,21H,5-7,10-11,15-16H2,(H,29,30,31)
Affinity DataIC50: 5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2 [828-1132](Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM400272(US10695337, Example 27 | US11285140, Example 27 | ...)
Show SMILES COc1ccc(F)c(c1)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C27H27FN8O2/c1-38-20-2-3-23(28)22(12-20)26(37)34-10-5-19(6-11-34)35-15-27(16-35,7-8-29)36-14-18(13-33-36)24-21-4-9-30-25(21)32-17-31-24/h2-4,9,12-14,17,19H,5-7,10-11,15-16H2,1H3,(H,30,31,32)
Affinity DataIC50: 5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2 [828-1132](Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM400273(US10695337, Example 28 | US11285140, Example 28 | ...)
Show SMILES Fc1cc(Cl)cc(c1)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C26H24ClFN8O/c27-19-9-17(10-20(28)11-19)25(37)34-7-2-21(3-8-34)35-14-26(15-35,4-5-29)36-13-18(12-33-36)23-22-1-6-30-24(22)32-16-31-23/h1,6,9-13,16,21H,2-4,7-8,14-15H2,(H,30,31,32)
Affinity DataIC50: 5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2 [828-1132](Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM400274(US10695337, Example 29 | US11285140, Example 29 | ...)
Show SMILES Fc1cc(Br)cc(c1)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C26H24BrFN8O/c27-19-9-17(10-20(28)11-19)25(37)34-7-2-21(3-8-34)35-14-26(15-35,4-5-29)36-13-18(12-33-36)23-22-1-6-30-24(22)32-16-31-23/h1,6,9-13,16,21H,2-4,7-8,14-15H2,(H,30,31,32)
Affinity DataIC50: 5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2 [828-1132](Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM400275(US10695337, Example 30 | US11285140, Example 30 | ...)
Show SMILES Clc1cc(C(=O)N2CCC(CC2)N2CC(CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)c(Cl)s1
Show InChI InChI=1S/C24H22Cl2N8OS/c25-19-9-18(21(26)36-19)23(35)32-7-2-16(3-8-32)33-12-24(13-33,4-5-27)34-11-15(10-31-34)20-17-1-6-28-22(17)30-14-29-20/h1,6,9-11,14,16H,2-4,7-8,12-13H2,(H,28,29,30)
Affinity DataIC50: 5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2 [828-1132](Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM400277(US10695337, Example 32 | US11285140, Example 32 | ...)
Show SMILES COc1c(F)c(F)cc(C(=O)N2CCC(CC2)N2CC(CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)c1F
Show InChI InChI=1S/C27H25F3N8O2/c1-40-24-21(29)19(10-20(28)22(24)30)26(39)36-8-3-17(4-9-36)37-13-27(14-37,5-6-31)38-12-16(11-35-38)23-18-2-7-32-25(18)34-15-33-23/h2,7,10-12,15,17H,3-5,8-9,13-14H2,1H3,(H,32,33,34)
Affinity DataIC50: 5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2 [828-1132](Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM400280(US10695337, Example 35 | US11285140, Example 35 | ...)
Show SMILES Fc1ccc(cc1F)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C26H24F2N8O/c27-21-2-1-17(11-22(21)28)25(37)34-9-4-19(5-10-34)35-14-26(15-35,6-7-29)36-13-18(12-33-36)23-20-3-8-30-24(20)32-16-31-23/h1-3,8,11-13,16,19H,4-6,9-10,14-15H2,(H,30,31,32)
Affinity DataIC50: 5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2 [828-1132](Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM400281(US10695337, Example 36 | US11285140, Example 36 | ...)
Show SMILES COc1cc(F)cc(c1)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C27H27FN8O2/c1-38-22-11-18(10-20(28)12-22)26(37)34-8-3-21(4-9-34)35-15-27(16-35,5-6-29)36-14-19(13-33-36)24-23-2-7-30-25(23)32-17-31-24/h2,7,10-14,17,21H,3-5,8-9,15-16H2,1H3,(H,30,31,32)
Affinity DataIC50: 5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2 [828-1132](Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM400282(US10695337, Example 37 | US11285140, Example 37 | ...)
Show SMILES COc1cc(cc(Cl)n1)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C26H26ClN9O2/c1-38-22-11-17(10-21(27)33-22)25(37)34-8-3-19(4-9-34)35-14-26(15-35,5-6-28)36-13-18(12-32-36)23-20-2-7-29-24(20)31-16-30-23/h2,7,10-13,16,19H,3-5,8-9,14-15H2,1H3,(H,29,30,31)
Affinity DataIC50: 5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2 [828-1132](Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM400283(US10695337, Example 38 | US11285140, Example 38 | ...)
Show SMILES COc1ccc(F)cc1C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C27H27FN8O2/c1-38-23-3-2-19(28)12-22(23)26(37)34-10-5-20(6-11-34)35-15-27(16-35,7-8-29)36-14-18(13-33-36)24-21-4-9-30-25(21)32-17-31-24/h2-4,9,12-14,17,20H,5-7,10-11,15-16H2,1H3,(H,30,31,32)
Affinity DataIC50: 5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2 [828-1132](Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM400285(US10695337, Example 39 | US11285140, Example 39 | ...)
Show SMILES COc1cccc(F)c1C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C27H27FN8O2/c1-38-22-4-2-3-21(28)23(22)26(37)34-11-6-19(7-12-34)35-15-27(16-35,8-9-29)36-14-18(13-33-36)24-20-5-10-30-25(20)32-17-31-24/h2-5,10,13-14,17,19H,6-8,11-12,15-16H2,1H3,(H,30,31,32)
Affinity DataIC50: 5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2 [828-1132](Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM400286(US10695337, Example 40 | US11285140, Example 40 | ...)
Show SMILES COc1cc(F)ccc1C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C27H27FN8O2/c1-38-23-12-19(28)2-3-21(23)26(37)34-10-5-20(6-11-34)35-15-27(16-35,7-8-29)36-14-18(13-33-36)24-22-4-9-30-25(22)32-17-31-24/h2-4,9,12-14,17,20H,5-7,10-11,15-16H2,1H3,(H,30,31,32)
Affinity DataIC50: 5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2 [828-1132](Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM400287(US10695337, Example 41 | US11285140, Example 41 | ...)
Show SMILES Fc1cccc(C(=O)N2CCC(CC2)N2CC(CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)c1F
Show InChI InChI=1S/C26H24F2N8O/c27-21-3-1-2-19(22(21)28)25(37)34-10-5-18(6-11-34)35-14-26(15-35,7-8-29)36-13-17(12-33-36)23-20-4-9-30-24(20)32-16-31-23/h1-4,9,12-13,16,18H,5-7,10-11,14-15H2,(H,30,31,32)
Affinity DataIC50: 5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2 [828-1132](Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM400289(US10695337, Example 43 | US11285140, Example 43 | ...)
Show SMILES Fc1ccc(F)c(c1)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C26H24F2N8O/c27-18-1-2-22(28)21(11-18)25(37)34-9-4-19(5-10-34)35-14-26(15-35,6-7-29)36-13-17(12-33-36)23-20-3-8-30-24(20)32-16-31-23/h1-3,8,11-13,16,19H,4-6,9-10,14-15H2,(H,30,31,32)
Affinity DataIC50: 5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2 [828-1132](Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM400566(US10695337, Example 322 | US11285140, Example 322 ...)
Show SMILES Oc1ccc(cc1F)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1c(F)cnc2[nH]ccc12
Show InChI InChI=1S/C27H25F2N7O2/c28-21-11-17(1-2-23(21)37)26(38)34-9-4-19(5-10-34)35-15-27(16-35,6-7-30)36-14-18(12-33-36)24-20-3-8-31-25(20)32-13-22(24)29/h1-3,8,11-14,19,37H,4-6,9-10,15-16H2,(H,31,32)
Affinity DataIC50: 5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2 [828-1132](Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM400567(US10695337, Example 323 | US11285140, Example 323 ...)
Show SMILES Oc1ccc(C(=O)N2CCC(CC2)N2CC(CC#N)(C2)n2cc(cn2)-c2c(F)cnc3[nH]ccc23)c(F)c1
Show InChI InChI=1S/C27H25F2N7O2/c28-22-11-19(37)1-2-20(22)26(38)34-9-4-18(5-10-34)35-15-27(16-35,6-7-30)36-14-17(12-33-36)24-21-3-8-31-25(21)32-13-23(24)29/h1-3,8,11-14,18,37H,4-6,9-10,15-16H2,(H,31,32)
Affinity DataIC50: 5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2 [828-1132](Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM400579(US11285140, Example 335 | US9999619, Example 335)
Show SMILES Brc1ccc(Br)c(c1)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1c(cnc2[nH]ccc12)C#N
Show InChI InChI=1S/C28H24Br2N8O/c29-20-1-2-24(30)23(11-20)27(39)36-9-4-21(5-10-36)37-16-28(17-37,6-7-31)38-15-19(14-35-38)25-18(12-32)13-34-26-22(25)3-8-33-26/h1-3,8,11,13-15,21H,4-6,9-10,16-17H2,(H,33,34)
Affinity DataIC50: 5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2 [828-1132](Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM400580(US11285140, Example 336 | US9999619, Example 336)
Show SMILES Brc1cc(Br)cc(c1)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1c(cnc2[nH]ccc12)C#N
Show InChI InChI=1S/C28H24Br2N8O/c29-21-9-18(10-22(30)11-21)27(39)36-7-2-23(3-8-36)37-16-28(17-37,4-5-31)38-15-20(14-35-38)25-19(12-32)13-34-26-24(25)1-6-33-26/h1,6,9-11,13-15,23H,2-4,7-8,16-17H2,(H,33,34)
Affinity DataIC50: 5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2 [828-1132](Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM400599(US10695337, Example 355 | US11285140, Example 355 ...)
Show SMILES CS(=O)(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1c(F)cnc2[nH]ccc12
Show InChI InChI=1S/C21H24FN7O2S/c1-32(30,31)28-8-3-16(4-9-28)27-13-21(14-27,5-6-23)29-12-15(10-26-29)19-17-2-7-24-20(17)25-11-18(19)22/h2,7,10-12,16H,3-5,8-9,13-14H2,1H3,(H,24,25)
Affinity DataIC50: 5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2 [828-1132](Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM400481(US10695337, Example 236 | US11285140, Example 236 ...)
Show SMILES Fc1c(Cl)ccc(c1CN1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12)C(F)(F)F
Show InChI InChI=1S/C27H25ClF4N8/c28-22-2-1-21(27(30,31)32)20(23(22)29)13-38-9-4-18(5-10-38)39-14-26(15-39,6-7-33)40-12-17(11-37-40)24-19-3-8-34-25(19)36-16-35-24/h1-3,8,11-12,16,18H,4-6,9-10,13-15H2,(H,34,35,36)
Affinity DataIC50: 5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2 [828-1132](Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM400486(US10695337, Example 241 | US11285140, Example 241 ...)
Show SMILES Fc1ccc(F)c(CN2C3CCC2CC(C3)N2CC(CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)c1Cl
Affinity DataIC50: 5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2 [828-1132](Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM400491(US10695337, Example 247 | US11285140, Example 247 ...)
Show SMILES O=S(=O)(N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12)c1ccccc1C#N
Show InChI InChI=1S/C26H25N9O2S/c27-9-8-26(35-15-20(14-32-35)24-22-5-10-29-25(22)31-18-30-24)16-33(17-26)21-6-11-34(12-7-21)38(36,37)23-4-2-1-3-19(23)13-28/h1-5,10,14-15,18,21H,6-8,11-12,16-17H2,(H,29,30,31)
Affinity DataIC50: 5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2 [828-1132](Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM400495(US10695337, Example 251 | US11285140, Example 251 ...)
Show SMILES Cn1ccc(n1)S(=O)(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C23H26N10O2S/c1-30-9-5-20(29-30)36(34,35)32-10-3-18(4-11-32)31-14-23(15-31,6-7-24)33-13-17(12-28-33)21-19-2-8-25-22(19)27-16-26-21/h2,5,8-9,12-13,16,18H,3-4,6,10-11,14-15H2,1H3,(H,25,26,27)
Affinity DataIC50: 5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2 [828-1132](Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM400497(US10695337, Example 253 | US11285140, Example 253 ...)
Show SMILES O=S(=O)(C1CCCC1)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C24H30N8O2S/c25-9-8-24(32-14-18(13-29-32)22-21-5-10-26-23(21)28-17-27-22)15-30(16-24)19-6-11-31(12-7-19)35(33,34)20-3-1-2-4-20/h5,10,13-14,17,19-20H,1-4,6-8,11-12,15-16H2,(H,26,27,28)
Affinity DataIC50: 5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2 [828-1132](Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM400502(US10695337, Example 258 | US11285140, Example 258 ...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C23H26N10O2S/c1-30-12-20(28-16-30)36(34,35)32-8-3-18(4-9-32)31-13-23(14-31,5-6-24)33-11-17(10-29-33)21-19-2-7-25-22(19)27-15-26-21/h2,7,10-12,15-16,18H,3-5,8-9,13-14H2,1H3,(H,25,26,27)
Affinity DataIC50: 5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2 [828-1132](Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM400503(US10695337, Example 259 | US11285140, Example 259 ...)
Show SMILES Cc1nc(cn1C)S(=O)(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C24H28N10O2S/c1-17-30-21(13-31(17)2)37(35,36)33-9-4-19(5-10-33)32-14-24(15-32,6-7-25)34-12-18(11-29-34)22-20-3-8-26-23(20)28-16-27-22/h3,8,11-13,16,19H,4-6,9-10,14-15H2,1-2H3,(H,26,27,28)
Affinity DataIC50: 5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2 [828-1132](Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM400514(US10695337, Example 270 | US11285140, Example 270 ...)
Show SMILES Fc1ccc(F)c(C(=O)N2CCC(CC2)N2CC(CC#N)(C2)n2ccc(c2)-c2ncnc3[nH]ccc23)c1F
Show InChI InChI=1S/C27H24F3N7O/c28-20-1-2-21(29)23(30)22(20)26(38)35-10-5-18(6-11-35)36-14-27(15-36,7-8-31)37-12-4-17(13-37)24-19-3-9-32-25(19)34-16-33-24/h1-4,9,12-13,16,18H,5-7,10-11,14-15H2,(H,32,33,34)
Affinity DataIC50: 5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2 [828-1132](Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM400517(US10695337, Example 273 | US9999619, Example 273)
Show SMILES Fc1ccc(cc1C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1ccc(c1)-c1ncnc2[nH]ccc12)C(F)(F)F
Show InChI InChI=1S/C28H25F4N7O/c29-23-2-1-19(28(30,31)32)13-22(23)26(40)37-10-5-20(6-11-37)38-15-27(16-38,7-8-33)39-12-4-18(14-39)24-21-3-9-34-25(21)36-17-35-24/h1-4,9,12-14,17,20H,5-7,10-11,15-16H2,(H,34,35,36)
Affinity DataIC50: 5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2 [828-1132](Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM400520(US10695337, Example 276 | US11285140, Example 276 ...)
Show SMILES Fc1cccc(C(=O)N2CCC(CC2)N2CC(CC#N)(C2)n2ccc(c2)-c2ncnc3[nH]ccc23)c1F
Show InChI InChI=1S/C27H25F2N7O/c28-22-3-1-2-20(23(22)29)26(37)34-11-6-19(7-12-34)35-15-27(16-35,8-9-30)36-13-5-18(14-36)24-21-4-10-31-25(21)33-17-32-24/h1-5,10,13-14,17,19H,6-8,11-12,15-16H2,(H,31,32,33)
Affinity DataIC50: 5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2 [828-1132](Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM400522(US10695337, Example 278 | US11285140, Example 278 ...)
Show SMILES Fc1ccc(F)c(c1)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1ccc(c1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C27H25F2N7O/c28-19-1-2-23(29)22(13-19)26(37)34-10-5-20(6-11-34)35-15-27(16-35,7-8-30)36-12-4-18(14-36)24-21-3-9-31-25(21)33-17-32-24/h1-4,9,12-14,17,20H,5-7,10-11,15-16H2,(H,31,32,33)
Affinity DataIC50: 5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2 [828-1132](Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM400523(US10695337, Example 279 | US11285140, Example 279 ...)
Show SMILES Fc1cccc(F)c1C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1ccc(c1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C27H25F2N7O/c28-21-2-1-3-22(29)23(21)26(37)34-11-6-19(7-12-34)35-15-27(16-35,8-9-30)36-13-5-18(14-36)24-20-4-10-31-25(20)33-17-32-24/h1-5,10,13-14,17,19H,6-8,11-12,15-16H2,(H,31,32,33)
Affinity DataIC50: 5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2 [828-1132](Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM400524(US10695337, Example 280 | US11285140, Example 280 ...)
Show SMILES Fc1ccc(C(=O)N2CCC(CC2)N2CC(CC#N)(C2)n2ccc(c2)-c2ncnc3[nH]ccc23)c(F)c1F
Show InChI InChI=1S/C27H24F3N7O/c28-21-2-1-19(22(29)23(21)30)26(38)35-10-5-18(6-11-35)36-14-27(15-36,7-8-31)37-12-4-17(13-37)24-20-3-9-32-25(20)34-16-33-24/h1-4,9,12-13,16,18H,5-7,10-11,14-15H2,(H,32,33,34)
Affinity DataIC50: 5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2 [828-1132](Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM400532(US10695337, Example 288 | US11285140, Example 288 ...)
Show SMILES COc1ccccc1NC(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1ccc(c1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C28H30N8O2/c1-38-24-5-3-2-4-23(24)33-27(37)34-13-8-21(9-14-34)35-17-28(18-35,10-11-29)36-15-7-20(16-36)25-22-6-12-30-26(22)32-19-31-25/h2-7,12,15-16,19,21H,8-10,13-14,17-18H2,1H3,(H,33,37)(H,30,31,32)
Affinity DataIC50: 5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2 [828-1132](Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM400541(US10695337, Example 297 | US11285140, Example 297 ...)
Show SMILES Oc1ccc(C(=O)N2CCC(CC2)N2CC(CC#N)(C2)n2cc(cn2)-c2ccnc3[nH]ccc23)c(F)c1
Show InChI InChI=1S/C27H26FN7O2/c28-24-13-20(36)1-2-23(24)26(37)33-11-5-19(6-12-33)34-16-27(17-34,7-8-29)35-15-18(14-32-35)21-3-9-30-25-22(21)4-10-31-25/h1-4,9-10,13-15,19,36H,5-7,11-12,16-17H2,(H,30,31)
Affinity DataIC50: 5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2 [828-1132](Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM400428(US10695337, Example 183 | US11285140, Example 183 ...)
Show SMILES Clc1cccc(NC(=O)N2CCC(CC2)N2CC(CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)c1
Show InChI InChI=1S/C26H26ClN9O/c27-19-2-1-3-20(12-19)33-25(37)34-10-5-21(6-11-34)35-15-26(16-35,7-8-28)36-14-18(13-32-36)23-22-4-9-29-24(22)31-17-30-23/h1-4,9,12-14,17,21H,5-7,10-11,15-16H2,(H,33,37)(H,29,30,31)
Affinity DataIC50: 5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2 [828-1132](Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM400429(US10695337, Example 184 | US11285140, Example 184 ...)
Show SMILES Clc1ccc(NC(=O)N2CCC(CC2)N2CC(CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)cc1
Show InChI InChI=1S/C26H26ClN9O/c27-19-1-3-20(4-2-19)33-25(37)34-11-6-21(7-12-34)35-15-26(16-35,8-9-28)36-14-18(13-32-36)23-22-5-10-29-24(22)31-17-30-23/h1-5,10,13-14,17,21H,6-8,11-12,15-16H2,(H,33,37)(H,29,30,31)
Affinity DataIC50: 5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2 [828-1132](Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM400438(US10695337, Example 193 | US11285140, Example 193 ...)
Show SMILES O=C(Nc1nc2ccccc2s1)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C27H26N10OS/c28-9-8-27(37-14-18(13-32-37)23-20-5-10-29-24(20)31-17-30-23)15-36(16-27)19-6-11-35(12-7-19)26(38)34-25-33-21-3-1-2-4-22(21)39-25/h1-5,10,13-14,17,19H,6-8,11-12,15-16H2,(H,29,30,31)(H,33,34,38)
Affinity DataIC50: 5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2 [828-1132](Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM400439(US10695337, Example 194 | US11285140, Example 194 ...)
Show SMILES Cn1c(NC(=O)N2CCC(CC2)N2CC(CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)nc2ccccc12
Show InChI InChI=1S/C28H29N11O/c1-36-23-5-3-2-4-22(23)34-26(36)35-27(40)37-12-7-20(8-13-37)38-16-28(17-38,9-10-29)39-15-19(14-33-39)24-21-6-11-30-25(21)32-18-31-24/h2-6,11,14-15,18,20H,7-9,12-13,16-17H2,1H3,(H,30,31,32)(H,34,35,40)
Affinity DataIC50: 5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2 [828-1132](Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM400451(US10695337, Example 206 | US11285140, Example 206 ...)
Show SMILES COC(=O)c1ccccc1NC(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C28H29N9O3/c1-40-26(38)21-4-2-3-5-23(21)34-27(39)35-12-7-20(8-13-35)36-16-28(17-36,9-10-29)37-15-19(14-33-37)24-22-6-11-30-25(22)32-18-31-24/h2-6,11,14-15,18,20H,7-9,12-13,16-17H2,1H3,(H,34,39)(H,30,31,32)
Affinity DataIC50: 5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2 [828-1132](Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM400452(US10695337, Example 207 | US11285140, Example 207 ...)
Show SMILES COC(=O)c1cc(F)ccc1NC(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C28H28FN9O3/c1-41-26(39)22-12-19(29)2-3-23(22)35-27(40)36-10-5-20(6-11-36)37-15-28(16-37,7-8-30)38-14-18(13-34-38)24-21-4-9-31-25(21)33-17-32-24/h2-4,9,12-14,17,20H,5-7,10-11,15-16H2,1H3,(H,35,40)(H,31,32,33)
Affinity DataIC50: 5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2 [828-1132](Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM400455(US10695337, Example 210 | US11285140, Example 210 ...)
Show SMILES Clc1cc(Cl)cc(CN2CCC(CC2)N2CC(CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)c1
Show InChI InChI=1S/C26H26Cl2N8/c27-20-9-18(10-21(28)11-20)13-34-7-2-22(3-8-34)35-15-26(16-35,4-5-29)36-14-19(12-33-36)24-23-1-6-30-25(23)32-17-31-24/h1,6,9-12,14,17,22H,2-4,7-8,13,15-16H2,(H,30,31,32)
Affinity DataIC50: 5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2 [828-1132](Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM400472(US10695337, Example 227 | US11285140, Example 227 ...)
Show SMILES Fc1cccc(Cl)c1CN1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C26H26ClFN8/c27-22-2-1-3-23(28)21(22)14-34-10-5-19(6-11-34)35-15-26(16-35,7-8-29)36-13-18(12-33-36)24-20-4-9-30-25(20)32-17-31-24/h1-4,9,12-13,17,19H,5-7,10-11,14-16H2,(H,30,31,32)
Affinity DataIC50: 5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2 [828-1132](Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM400473(US10695337, Example 228 | US11285140, Example 228 ...)
Show SMILES Fc1ccc(Cl)c(F)c1CN1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C26H25ClF2N8/c27-21-1-2-22(28)20(23(21)29)13-35-9-4-18(5-10-35)36-14-26(15-36,6-7-30)37-12-17(11-34-37)24-19-3-8-31-25(19)33-16-32-24/h1-3,8,11-12,16,18H,4-6,9-10,13-15H2,(H,31,32,33)
Affinity DataIC50: 5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase JAK2 [828-1132](Homo sapiens (Human))
Incyte Corporation

US Patent
LigandPNGBDBM400477(US10695337, Example 232 | US11285140, Example 232 ...)
Show SMILES N#CCC1(CN(C1)C1CCN(Cc2cc3ccccc3o2)CC1)n1cc(cn1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C28H28N8O/c29-9-8-28(36-15-21(14-33-36)26-24-5-10-30-27(24)32-19-31-26)17-35(18-28)22-6-11-34(12-7-22)16-23-13-20-3-1-2-4-25(20)37-23/h1-5,10,13-15,19,22H,6-8,11-12,16-18H2,(H,30,31,32)
Affinity DataIC50: 5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Displayed 1 to 50 (of 1463 total ) | Next | Last >>
Jump to: