Compile Data Set for Download or QSAR
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Found 37 Enz. Inhib. hit(s) with all data for entry = 50012629
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM18627((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Affinity DataIC50:  0.100nMAssay Description:Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...More data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50121165(3-(3,3-Dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-5...)
Affinity DataIC50:  13nMAssay Description:Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50121167(5-fluoro-3-(2'-oxo-1',2'-dihydrospiro[cyclopentane...)
Affinity DataIC50:  14nMAssay Description:Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50121163(3-(2'-oxo-1',2'-dihydrospiro[cyclohexane-1,3'-indo...)
Affinity DataIC50:  15nMAssay Description:Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50121172(5-fluoro-3-(2'-oxo-1',2'-dihydrospiro[cyclohexane-...)
Affinity DataIC50:  20nMAssay Description:Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50121176(3-(2'-oxo-1',2'-dihydrospiro[cyclopentane-1,3'-ind...)
Affinity DataIC50:  21nMAssay Description:Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50121157(5-(3-Fluoro-5-nitro-phenyl)-3,3-dimethyl-1,3-dihyd...)
Affinity DataIC50:  27nMAssay Description:Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50121164(3-(3,3-Dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-b...)
Affinity DataIC50:  27nMAssay Description:Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50121178(5-(3,3-Dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-t...)
Affinity DataIC50:  28nMAssay Description:Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50121184(3,3-Dimethyl-5-(5-nitro-thiophen-2-yl)-1,3-dihydro...)
Affinity DataIC50:  29nMAssay Description:Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50121161(5-(3,3-Dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-4...)
Affinity DataIC50:  29nMAssay Description:Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50121183(5-(3-Chloro-5-fluoro-phenyl)-3,3-dimethyl-1,3-dihy...)
Affinity DataIC50:  29nMAssay Description:Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50121168(3,3-Dimethyl-5-(3-nitro-phenyl)-1,3-dihydro-indol-...)
Affinity DataIC50:  31nMAssay Description:Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50121158(5'-(3-chlorophenyl)spiro[cyclopentane-1,3'-indol]-...)
Affinity DataIC50:  32nMAssay Description:Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50121166(5'-(3-nitrophenyl)spiro[cyclopentane-1,3'-indol]-2...)
Affinity DataIC50:  38nMAssay Description:Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50066523(2,2,4-Trimethyl-6-(3-nitro-phenyl)-1,2-dihydro-qui...)
Affinity DataIC50:  41nMAssay Description:Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50121172(5-fluoro-3-(2'-oxo-1',2'-dihydrospiro[cyclohexane-...)
Affinity DataIC50:  51nMAssay Description:Inhibition of 3 nM [3H]-R5020 binding to progesterone receptor of human T47D cell cytosolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50121180(5'-(3-chlorophenyl)spiro[cyclohexane-1,3'-indol]-2...)
Affinity DataIC50:  56nMAssay Description:Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50121156(5-(3-Chloro-phenyl)-3,3-dimethyl-1,3-dihydro-indol...)
Affinity DataIC50:  66nMAssay Description:Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50121173(5'-(3-chlorophenyl)spiro[cyclobutane-1,3'-indol]-2...)
Affinity DataIC50:  71nMAssay Description:Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50121162(5'-(3-chlorophenyl)spiro[cyclopropane-1,3'-indol]-...)
Affinity DataIC50:  85nMAssay Description:Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50121170(5'-(3-nitrophenyl)spiro[cyclohexane-1,3'-indol]-2'...)
Affinity DataIC50:  96nMAssay Description:Inhibition of 3 nM [3H]-R5020 binding to progesterone receptor of human T47D cell cytosolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50121170(5'-(3-nitrophenyl)spiro[cyclohexane-1,3'-indol]-2'...)
Affinity DataIC50:  96nMAssay Description:Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50121160(5-(3,5-Dichloro-phenyl)-3,3-dimethyl-1,3-dihydro-i...)
Affinity DataIC50:  100nMAssay Description:Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50121177(3-Methyl-5-(3-nitro-phenyl)-1,3-dihydro-indol-2-on...)
Affinity DataIC50:  102nMAssay Description:Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50121181(5-(3-Chloro-phenyl)-3-ethyl-1,3-dihydro-indol-2-on...)
Affinity DataIC50:  130nMAssay Description:Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50121159(5-(3-Chloro-phenyl)-3-methyl-1,3-dihydro-indol-2-o...)
Affinity DataIC50:  185nMAssay Description:Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50121166(5'-(3-nitrophenyl)spiro[cyclopentane-1,3'-indol]-2...)
Affinity DataIC50:  193nMAssay Description:Inhibition of 3 nM [3H]-R5020 binding to progesterone receptor of human T47D cell cytosolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50121182(5-(3-Acetyl-phenyl)-3,3-dimethyl-1,3-dihydro-indol...)
Affinity DataIC50:  206nMAssay Description:Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50121171(5-(3-Chloro-phenyl)-3,3-diethyl-1,3-dihydro-indol-...)
Affinity DataIC50:  229nMAssay Description:Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50121167(5-fluoro-3-(2'-oxo-1',2'-dihydrospiro[cyclopentane...)
Affinity DataIC50:  230nMAssay Description:Inhibition of 3 nM [3H]-R5020 binding to progesterone receptor of human T47D cell cytosolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50121175(3-Benzyl-5-(3-chloro-phenyl)-3-methyl-1,3-dihydro-...)
Affinity DataIC50:  267nMAssay Description:Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50121179(5-(3-Chloro-phenyl)-1,3-dihydro-indol-2-one | CHEM...)
Affinity DataIC50:  296nMAssay Description:Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50121169(5-(3-Nitro-phenyl)-1,3-dihydro-indol-2-one | CHEMB...)
Affinity DataIC50:  299nMAssay Description:Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50121155(5-(3-Methoxy-phenyl)-3,3-dimethyl-1,3-dihydro-indo...)
Affinity DataIC50:  300nMAssay Description:Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50121180(5'-(3-chlorophenyl)spiro[cyclohexane-1,3'-indol]-2...)
Affinity DataIC50:  477nMAssay Description:Inhibition of 3 nM [3H]-R5020 binding to progesterone receptor of human T47D cell cytosolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50121168(3,3-Dimethyl-5-(3-nitro-phenyl)-1,3-dihydro-indol-...)
Affinity DataIC50:  509nMAssay Description:Inhibition of 3 nM [3H]-R5020 binding to progesterone receptor of human T47D cell cytosolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed