Compile Data Set for Download or QSAR
maximum 50k data
Found 20 Enz. Inhib. hit(s) with all data for entry = 2532
TargetDNA polymerase III PolC-type(Bacillus subtilis)
Microbiotix

LigandPNGBDBM21688(1-cyclopropyl-7-[4-(4-{4-[(3-ethyl-4-methylphenyl)...)
Affinity DataKi:  19nM ΔG°:  -44.8kJ/molepH: 7.5 T: 2°CAssay Description:Reaction velocities were determined at each dGTP concentration and used to create double reciprocal plots of velocity versus dGTP concentration. The ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase III PolC-type(Bacillus subtilis)
Microbiotix

LigandPNGBDBM21686(3-(4-hydroxybutyl)-6-(3-ethyl-4-methylanilino)urac...)
Affinity DataKi:  63nM ΔG°:  -41.8kJ/molepH: 7.5 T: 2°CAssay Description:Reaction velocities were determined at each dGTP concentration and used to create double reciprocal plots of velocity versus dGTP concentration. The ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase III subunit alpha(Bacillus subtilis)
Microbiotix

LigandPNGBDBM21686(3-(4-hydroxybutyl)-6-(3-ethyl-4-methylanilino)urac...)
Affinity DataKi:  1.17E+5nM ΔG°:  -22.8kJ/molepH: 7.5 T: 2°CAssay Description:Reaction velocities were determined at each dGTP concentration and used to create double reciprocal plots of velocity versus dGTP concentration. The ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase III subunit alpha(Bacillus subtilis)
Microbiotix

LigandPNGBDBM21688(1-cyclopropyl-7-[4-(4-{4-[(3-ethyl-4-methylphenyl)...)
Affinity DataKi: >4.82E+5nM ΔG°: >-19.2kJ/molepH: 7.5 T: 2°CAssay Description:Reaction velocities were determined at each dGTP concentration and used to create double reciprocal plots of velocity versus dGTP concentration. The ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha subunit B(Bos taurus (bovine))
Microbiotix

LigandPNGBDBM21688(1-cyclopropyl-7-[4-(4-{4-[(3-ethyl-4-methylphenyl)...)
Affinity DataKi: >4.82E+5nM ΔG°: >-19.7kJ/molepH: 7.5 T: 2°CAssay Description:Reaction velocities were determined at each dGTP concentration and used to create double reciprocal plots of velocity versus dGTP concentration. The ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase III subunit alpha(Escherichia coli)
Microbiotix

LigandPNGBDBM21688(1-cyclopropyl-7-[4-(4-{4-[(3-ethyl-4-methylphenyl)...)
Affinity DataKi: >4.82E+5nM ΔG°: >-19.2kJ/molepH: 7.5 T: 2°CAssay Description:Reaction velocities were determined at each dGTP concentration and used to create double reciprocal plots of velocity versus dGTP concentration. The ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase subunit gamma-1(Homo sapiens (Human))
Microbiotix

LigandPNGBDBM21688(1-cyclopropyl-7-[4-(4-{4-[(3-ethyl-4-methylphenyl)...)
Affinity DataKi:  6.84E+5nM ΔG°:  -18.8kJ/molepH: 7.5 T: 2°CAssay Description:Reaction velocities were determined at each dGTP concentration and used to create double reciprocal plots of velocity versus dGTP concentration. The ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase III subunit alpha(Escherichia coli)
Microbiotix

LigandPNGBDBM21686(3-(4-hydroxybutyl)-6-(3-ethyl-4-methylanilino)urac...)
Affinity DataKi: >1.01E+6nM ΔG°: >-17.4kJ/molepH: 7.5 T: 2°CAssay Description:Reaction velocities were determined at each dGTP concentration and used to create double reciprocal plots of velocity versus dGTP concentration. The ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase subunit gamma-1(Homo sapiens (Human))
Microbiotix

LigandPNGBDBM21686(3-(4-hydroxybutyl)-6-(3-ethyl-4-methylanilino)urac...)
Affinity DataKi: >1.01E+6nM ΔG°: >-17.8kJ/molepH: 7.5 T: 2°CAssay Description:Reaction velocities were determined at each dGTP concentration and used to create double reciprocal plots of velocity versus dGTP concentration. The ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha subunit B(Bos taurus (bovine))
Microbiotix

LigandPNGBDBM21686(3-(4-hydroxybutyl)-6-(3-ethyl-4-methylanilino)urac...)
Affinity DataKi: >1.01E+6nM ΔG°: >-17.8kJ/molepH: 7.5 T: 2°CAssay Description:Reaction velocities were determined at each dGTP concentration and used to create double reciprocal plots of velocity versus dGTP concentration. The ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 4 subunit A [V210L]/B(Bacillus subtilis)
Microbiotix

LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  1.70E+3nMpH: 7.5 T: 2°CAssay Description:The 50% inhibitory concentration (IC50) is defined as the concentration of compound that inhibits the decatenation of kinetoplast DNA by 50%.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetDNA topoisomerase 4 subunit A [V210L]/B(Bacillus subtilis)
Microbiotix

LigandPNGBDBM21689(1-cyclopropyl-6,8-difluoro-7-(3-methylpiperazin-1-...)
Affinity DataIC50:  4.20E+3nMpH: 7.5 T: 2°CAssay Description:The 50% inhibitory concentration (IC50) is defined as the concentration of compound that inhibits the decatenation of kinetoplast DNA by 50%.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Bacillus subtilis)
Microbiotix

LigandPNGBDBM21689(1-cyclopropyl-6,8-difluoro-7-(3-methylpiperazin-1-...)
Affinity DataIC50:  5.60E+3nMpH: 7.5 T: 2°CAssay Description:The 50% inhibitory concentration (IC50) is defined as the concentration of compound that inhibits the decatenation of kinetoplast DNA by 50%.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Bacillus subtilis)
Microbiotix

LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  6.30E+3nMpH: 7.5 T: 2°CAssay Description:The 50% inhibitory concentration (IC50) is defined as the concentration of compound that inhibits the decatenation of kinetoplast DNA by 50%.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetDNA gyrase subunit A/B(Bacillus subtilis)
Microbiotix

LigandPNGBDBM21688(1-cyclopropyl-7-[4-(4-{4-[(3-ethyl-4-methylphenyl)...)
Affinity DataIC50:  3.10E+4nMpH: 7.5 T: 2°CAssay Description:The 50% inhibitory concentration (IC50) is defined as the concentration of compound that inhibits the decatenation of kinetoplast DNA by 50%.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 4 subunit A [V210L]/B(Bacillus subtilis)
Microbiotix

LigandPNGBDBM21688(1-cyclopropyl-7-[4-(4-{4-[(3-ethyl-4-methylphenyl)...)
Affinity DataIC50:  4.36E+4nMpH: 7.5 T: 2°CAssay Description:The 50% inhibitory concentration (IC50) is defined as the concentration of compound that inhibits the decatenation of kinetoplast DNA by 50%.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Bacillus subtilis)
Microbiotix

LigandPNGBDBM21691(1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridi...)
Affinity DataIC50:  1.49E+5nMpH: 7.5 T: 2°CAssay Description:The 50% inhibitory concentration (IC50) is defined as the concentration of compound that inhibits the decatenation of kinetoplast DNA by 50%.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Bacillus subtilis)
Microbiotix

LigandPNGBDBM21686(3-(4-hydroxybutyl)-6-(3-ethyl-4-methylanilino)urac...)
Affinity DataIC50: >5.00E+5nMpH: 7.5 T: 2°CAssay Description:The 50% inhibitory concentration (IC50) is defined as the concentration of compound that inhibits the decatenation of kinetoplast DNA by 50%.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 4 subunit A [V210L]/B(Bacillus subtilis)
Microbiotix

LigandPNGBDBM21686(3-(4-hydroxybutyl)-6-(3-ethyl-4-methylanilino)urac...)
Affinity DataIC50: >5.00E+5nMpH: 7.5 T: 2°CAssay Description:The 50% inhibitory concentration (IC50) is defined as the concentration of compound that inhibits the decatenation of kinetoplast DNA by 50%.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 4 subunit A [V210L]/B(Bacillus subtilis)
Microbiotix

LigandPNGBDBM21691(1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridi...)
Affinity DataIC50:  1.09E+6nMpH: 7.5 T: 2°CAssay Description:The 50% inhibitory concentration (IC50) is defined as the concentration of compound that inhibits the decatenation of kinetoplast DNA by 50%.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed