Compile Data Set for Download or QSAR
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Found 21 Enz. Inhib. hit(s) with all data for entry = 50027262
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50263432(2-(((1R,5S)-6-((6-chloropyridin-3-yloxy)methyl)-3-...)
Affinity DataEC50:  511nMAssay Description:Activity at rat mGluR2 receptor expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50263431(2-(((1R,5S)-6-((5-chloropyridin-2-yloxy)methyl)-3-...)
Affinity DataEC50:  26nMAssay Description:Activity at rat mGluR2 receptor expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50263434(1-methyl-2-(((1R,5S)-6-((4-(trifluoromethyl)phenox...)
Affinity DataEC50:  20nMAssay Description:Activity at rat mGluR2 receptor expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50274140(1-methyl-2-(((1R,5S)-6-((4-(trifluoromethyl)phenox...)
Affinity DataEC50:  251nMAssay Description:Activity at rat mGluR2 receptor expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50274141(3-methyl-2-(((1R,5S)-6-(phenoxymethyl)-3-aza-bicyc...)
Affinity DataEC50:  2.12E+3nMAssay Description:Activity at rat mGluR2 receptor expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50274142(3-methyl-2-(((1R,5S)-6-((4-(trifluoromethyl)phenox...)
Affinity DataEC50:  419nMAssay Description:Activity at rat mGluR2 receptor expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50274143(2-(((1R,5S)-6-((3-chlorophenoxy)methyl)-3-aza-bicy...)
Affinity DataEC50:  64nMAssay Description:Activity at rat mGluR2 receptor expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50274144(2-(((1R,5S)-6-((3-chlorophenoxy)methyl)-3-aza-bicy...)
Affinity DataEC50:  86nMAssay Description:Activity at rat mGluR2 receptor expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50263426(1-methyl-2-(((1R,5S)-6-(phenoxymethyl)-3-aza-bicyc...)
Affinity DataEC50:  24nMAssay Description:Activity at rat mGluR2 receptor expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50263427(2-(((1R,5S)-6-(phenoxymethyl)-3-aza-bicyclo[3.1.0]...)
Affinity DataEC50: >1.00E+4nMAssay Description:Activity at rat mGluR2 receptor expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50263428(2-(((1R,5S)-6-(phenoxymethyl)-3-aza-bicyclo[3.1.0]...)
Affinity DataEC50: >1.00E+4nMAssay Description:Activity at rat mGluR2 receptor expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50263429(3-(((1R,5S)-6-(phenoxymethyl)-3-aza-bicyclo[3.1.0]...)
Affinity DataEC50:  9.75E+3nMAssay Description:Activity at rat mGluR2 receptor expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50263430(1-cyclopropyl-2-(((1R,5S)-6-(phenoxymethyl)-3-aza-...)
Affinity DataEC50:  3.02E+3nMAssay Description:Activity at rat mGluR2 receptor expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50263353(1-(((1R,5S)-6-(phenoxymethyl)-3-aza-bicyclo[3.1.0]...)
Affinity DataEC50:  967nMAssay Description:Activity at rat mGluR2 receptor expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50263354(2-[(1R,5S)-6-(Biphenyl-3-yloxymethyl)-3-aza-bicycl...)
Affinity DataEC50:  113nMAssay Description:Activity at rat mGluR2 receptor expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50263355(2-(((1R,5S)-6-((2,5-difluorophenoxy)methyl)-3-aza-...)
Affinity DataEC50:  7nMAssay Description:Activity at rat mGluR2 receptor expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50263389(2-(((1R,5S)-6-((4-isopropylphenoxy)methyl)-3-aza-b...)
Affinity DataEC50:  26nMAssay Description:Activity at rat mGluR2 receptor expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50263390(2-(((1R,5S)-6-((4-chlorophenoxy)methyl)-3-aza-bicy...)
Affinity DataEC50:  26nMAssay Description:Activity at rat mGluR2 receptor expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50263391(2-(((1R,5S)-6-((4-chloro-2-fluorophenoxy)methyl)-3...)
Affinity DataEC50:  8nMAssay Description:Activity at rat mGluR2 receptor expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50263392(1-methyl-2-(((1R,5S)-6-((4-(trifluoromethyl)phenox...)
Affinity DataEC50:  85nMAssay Description:Activity at rat mGluR2 receptor expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50263433(1-methyl-2-(((1R,5S)-6-((5-(trifluoromethyl)pyridi...)
Affinity DataEC50:  30nMAssay Description:Activity at rat mGluR2 receptor expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed