Compile Data Set for Download or QSAR
maximum 50k data
Found 38 Enz. Inhib. hit(s) with all data for entry = 50033465
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246060(CHEMBL472212 | CHEMBL541649 | D3RKN_6 | N-methyl-N...)
Affinity DataIC50:  1nMAssay Description:Inhibition of purified activated FAK kinase domain (410-689) using ATP and Glu and Tyr random peptide polymer substrate by fluorescence polarization ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-tyrosine kinase 2-beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50418579(CHEMBL2029181)
Affinity DataIC50:  10nMAssay Description:Inhibition of PYK2 by PYK2-LI-COR cellular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-tyrosine kinase 2-beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50418579(CHEMBL2029181)
Affinity DataIC50:  16nMAssay Description:Inhibition of PYK2 assessed as reduction in peptide substrate phosphoryltion by fluorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-tyrosine kinase 2-beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50418584(CHEMBL2029177)
Affinity DataIC50:  21nMAssay Description:Inhibition of PYK2 assessed as reduction in peptide substrate phosphoryltion by fluorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-tyrosine kinase 2-beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50418579(CHEMBL2029181)
Affinity DataIC50:  22nMAssay Description:Inhibition of PYK2 by PYK2-LI-COR cellular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-tyrosine kinase 2-beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50418580(CHEMBL2029182)
Affinity DataIC50:  22nMAssay Description:Inhibition of PYK2 assessed as reduction in peptide substrate phosphoryltion by fluorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-tyrosine kinase 2-beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50418584(CHEMBL2029177)
Affinity DataIC50:  24nMAssay Description:Inhibition of PYK2 by PYK2-LI-COR cellular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-tyrosine kinase 2-beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50418578(CHEMBL2029180)
Affinity DataIC50:  29nMAssay Description:Inhibition of PYK2 by PYK2-LI-COR cellular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-tyrosine kinase 2-beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246060(CHEMBL472212 | CHEMBL541649 | D3RKN_6 | N-methyl-N...)
Affinity DataIC50:  31nMAssay Description:Inhibition of PYK2 assessed as reduction in peptide substrate phosphoryltion by fluorimetric methodMore data for this Ligand-Target Pair
TargetProtein-tyrosine kinase 2-beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50418579(CHEMBL2029181)
Affinity DataIC50:  32nMAssay Description:Inhibition of PYK2 assessed as reduction in peptide substrate phosphoryltion by fluorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-tyrosine kinase 2-beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50418580(CHEMBL2029182)
Affinity DataIC50:  34nMAssay Description:Inhibition of PYK2 by PYK2-LI-COR cellular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-tyrosine kinase 2-beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50418579(CHEMBL2029181)
Affinity DataIC50:  37nMAssay Description:Inhibition of PYK2 by PYK2-LI-COR cellular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-tyrosine kinase 2-beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50418578(CHEMBL2029180)
Affinity DataIC50:  43nMAssay Description:Inhibition of PYK2 assessed as reduction in peptide substrate phosphoryltion by fluorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-tyrosine kinase 2-beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246285(CHEMBL519418 | N4-((1R,2R)-2-(dimethylamino)cyclop...)
Affinity DataIC50:  60nMAssay Description:Inhibition of PYK2 by PYK2-LI-COR cellular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-tyrosine kinase 2-beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246060(CHEMBL472212 | CHEMBL541649 | D3RKN_6 | N-methyl-N...)
Affinity DataIC50:  63nMAssay Description:Inhibition of PYK2 by PYK2-LI-COR cellular assayMore data for this Ligand-Target Pair
TargetProtein-tyrosine kinase 2-beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50418579(CHEMBL2029181)
Affinity DataIC50:  63nMAssay Description:Inhibition of PYK2 assessed as reduction in peptide substrate phosphoryltion by fluorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-tyrosine kinase 2-beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50418581(CHEMBL2029183)
Affinity DataIC50:  65nMAssay Description:Inhibition of PYK2 assessed as reduction in peptide substrate phosphoryltion by fluorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-tyrosine kinase 2-beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50418578(CHEMBL2029180)
Affinity DataIC50:  67nMAssay Description:Inhibition of PYK2 assessed as reduction in peptide substrate phosphoryltion by fluorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-tyrosine kinase 2-beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50418578(CHEMBL2029180)
Affinity DataIC50:  67nMAssay Description:Inhibition of PYK2 assessed as reduction in peptide substrate phosphoryltion by fluorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-tyrosine kinase 2-beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50418578(CHEMBL2029180)
Affinity DataIC50:  76nMAssay Description:Inhibition of PYK2 by PYK2-LI-COR cellular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-tyrosine kinase 2-beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246327(4-(4-((1R,2R)-2-(dimethylamino)cyclopentylamino)-5...)
Affinity DataIC50:  88nMAssay Description:Inhibition of PYK2 by PYK2-LI-COR cellular assayMore data for this Ligand-Target Pair
TargetProtein-tyrosine kinase 2-beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50345900(CHEMBL1783837 | N-cyclopropyl-4-(4-((1R,2R)-2-(dim...)
Affinity DataIC50:  95nMAssay Description:Inhibition of PYK2 by PYK2-LI-COR cellular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-tyrosine kinase 2-beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246285(CHEMBL519418 | N4-((1R,2R)-2-(dimethylamino)cyclop...)
Affinity DataIC50:  95nMAssay Description:Inhibition of PYK2 assessed as reduction in peptide substrate phosphoryltion by fluorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-tyrosine kinase 2-beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50418578(CHEMBL2029180)
Affinity DataIC50:  98nMAssay Description:Inhibition of PYK2 by PYK2-LI-COR cellular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-tyrosine kinase 2-beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246327(4-(4-((1R,2R)-2-(dimethylamino)cyclopentylamino)-5...)
Affinity DataIC50:  140nMAssay Description:Inhibition of PYK2 assessed as reduction in peptide substrate phosphoryltion by fluorimetric methodMore data for this Ligand-Target Pair
TargetProtein-tyrosine kinase 2-beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50345900(CHEMBL1783837 | N-cyclopropyl-4-(4-((1R,2R)-2-(dim...)
Affinity DataIC50:  140nMAssay Description:Inhibition of PYK2 assessed as reduction in peptide substrate phosphoryltion by fluorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-tyrosine kinase 2-beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50418581(CHEMBL2029183)
Affinity DataIC50:  320nMAssay Description:Inhibition of PYK2 by PYK2-LI-COR cellular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50418579(CHEMBL2029181)
Affinity DataIC50:  790nMAssay Description:Inhibition of purified activated FAK kinase domain (410-689) using ATP and Glu and Tyr random peptide polymer substrate by fluorescence polarization ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50418578(CHEMBL2029180)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of purified activated FAK kinase domain (410-689) using ATP and Glu and Tyr random peptide polymer substrate by fluorescence polarization ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50418579(CHEMBL2029181)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of purified activated FAK kinase domain (410-689) using ATP and Glu and Tyr random peptide polymer substrate by fluorescence polarization ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246285(CHEMBL519418 | N4-((1R,2R)-2-(dimethylamino)cyclop...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of purified activated FAK kinase domain (410-689) using ATP and Glu and Tyr random peptide polymer substrate by fluorescence polarization ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50418578(CHEMBL2029180)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of purified activated FAK kinase domain (410-689) using ATP and Glu and Tyr random peptide polymer substrate by fluorescence polarization ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50345900(CHEMBL1783837 | N-cyclopropyl-4-(4-((1R,2R)-2-(dim...)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of purified activated FAK kinase domain (410-689) using ATP and Glu and Tyr random peptide polymer substrate by fluorescence polarization ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50418578(CHEMBL2029180)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of purified activated FAK kinase domain (410-689) using ATP and Glu and Tyr random peptide polymer substrate by fluorescence polarization ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50418579(CHEMBL2029181)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of purified activated FAK kinase domain (410-689) using ATP and Glu and Tyr random peptide polymer substrate by fluorescence polarization ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246327(4-(4-((1R,2R)-2-(dimethylamino)cyclopentylamino)-5...)
Affinity DataIC50:  3.80E+3nMAssay Description:Inhibition of purified activated FAK kinase domain (410-689) using ATP and Glu and Tyr random peptide polymer substrate by fluorescence polarization ...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246285(CHEMBL519418 | N4-((1R,2R)-2-(dimethylamino)cyclop...)
Affinity DataIC50:  4.70E+3nMAssay Description:Inhibition of human ERG by cell based by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50418578(CHEMBL2029180)
Affinity DataIC50:  2.03E+4nMAssay Description:Inhibition of human ERG by cell based by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed