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Found 23 Enz. Inhib. hit(s) with all data for entry = 50047125
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
School Of Medicine Of University Of Electronic Science And Technology Of China

Curated by ChEMBL
LigandPNGBDBM50149945(CHEMBL3770205)
Affinity DataIC50:  0.230nMAssay Description:Inhibition of 5-HT in Wistar rat synaptosomes assessed as [3H]-5-HT reuptake by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
School Of Medicine Of University Of Electronic Science And Technology Of China

Curated by ChEMBL
LigandPNGBDBM50149944(CHEMBL3770202)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of 5-HT in Wistar rat synaptosomes assessed as [3H]-5-HT reuptake by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCatechol O-methyltransferase(Rattus norvegicus (Rat))
School Of Medicine Of University Of Electronic Science And Technology Of China

Curated by ChEMBL
LigandPNGBDBM50108877((3,4-Dihydroxy-5-nitro-phenyl)-p-tolyl-methanone |...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of rat COMTMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
School Of Medicine Of University Of Electronic Science And Technology Of China

Curated by ChEMBL
LigandPNGBDBM50149947(CHEMBL3770126)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of 5-HT in Wistar rat synaptosomes assessed as [3H]-5-HT reuptake by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
School Of Medicine Of University Of Electronic Science And Technology Of China

Curated by ChEMBL
LigandPNGBDBM50149946(CHEMBL3770400)
Affinity DataIC50:  9.90nMAssay Description:Inhibition of DAT in Wistar rat synaptosomes assessed as [3H]-DA reuptake by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
School Of Medicine Of University Of Electronic Science And Technology Of China

Curated by ChEMBL
LigandPNGBDBM50337911((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N,N-dim...)
Affinity DataIC50:  10nMAssay Description:Inhibition of recombinant human norepinephrine transporter assessed as reduction in [3H]-NA reuptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
School Of Medicine Of University Of Electronic Science And Technology Of China

Curated by ChEMBL
LigandPNGBDBM50149946(CHEMBL3770400)
Affinity DataIC50:  10nMAssay Description:Inhibition of 5-HT in Wistar rat synaptosomes assessed as [3H]-5-HT reuptake by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
School Of Medicine Of University Of Electronic Science And Technology Of China

Curated by ChEMBL
LigandPNGBDBM50149942(CHEMBL3770663)
Affinity DataIC50:  11nMAssay Description:Inhibition of recombinant human 5-HT transporter expressed in HEK293 cells assessed as reduction in [3H]-5-HT reuptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
School Of Medicine Of University Of Electronic Science And Technology Of China

Curated by ChEMBL
LigandPNGBDBM50337911((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N,N-dim...)
Affinity DataIC50:  12nMAssay Description:Inhibition of recombinant human 5-HT transporter expressed in HEK293 cells assessed as reduction in [3H]-5-HT reuptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
School Of Medicine Of University Of Electronic Science And Technology Of China

Curated by ChEMBL
LigandPNGBDBM50149944(CHEMBL3770202)
Affinity DataIC50:  13nMAssay Description:Inhibition of DAT in Wistar rat synaptosomes assessed as [3H]-DA reuptake by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
School Of Medicine Of University Of Electronic Science And Technology Of China

Curated by ChEMBL
LigandPNGBDBM50149940(CHEMBL3770651 | US10562878, Compound 203)
Affinity DataIC50:  13nMAssay Description:Inhibition of recombinant human DA transporter assessed as reduction in [3H]-DA reuptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
School Of Medicine Of University Of Electronic Science And Technology Of China

Curated by ChEMBL
LigandPNGBDBM50149940(CHEMBL3770651 | US10562878, Compound 203)
Affinity DataIC50:  17nMAssay Description:Inhibition of recombinant human norepinephrine transporter assessed as reduction in [3H]-NA reuptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
School Of Medicine Of University Of Electronic Science And Technology Of China

Curated by ChEMBL
LigandPNGBDBM50149941(CHEMBL3769872)
Affinity DataIC50:  18nMAssay Description:Inhibition of recombinant human 5-HT transporter expressed in HEK293 cells assessed as reduction in [3H]-5-HT reuptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
School Of Medicine Of University Of Electronic Science And Technology Of China

Curated by ChEMBL
LigandPNGBDBM50149941(CHEMBL3769872)
Affinity DataIC50:  21nMAssay Description:Inhibition of recombinant human DA transporter assessed as reduction in [3H]-DA reuptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
School Of Medicine Of University Of Electronic Science And Technology Of China

Curated by ChEMBL
LigandPNGBDBM50149941(CHEMBL3769872)
Affinity DataIC50:  33nMAssay Description:Inhibition of recombinant human norepinephrine transporter assessed as reduction in [3H]-NA reuptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
School Of Medicine Of University Of Electronic Science And Technology Of China

Curated by ChEMBL
LigandPNGBDBM50149942(CHEMBL3770663)
Affinity DataIC50:  33nMAssay Description:Inhibition of recombinant human norepinephrine transporter assessed as reduction in [3H]-NA reuptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
School Of Medicine Of University Of Electronic Science And Technology Of China

Curated by ChEMBL
LigandPNGBDBM50149945(CHEMBL3770205)
Affinity DataIC50:  34nMAssay Description:Inhibition of DAT in Wistar rat synaptosomes assessed as [3H]-DA reuptake by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
School Of Medicine Of University Of Electronic Science And Technology Of China

Curated by ChEMBL
LigandPNGBDBM50337911((+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N,N-dim...)
Affinity DataIC50:  36nMAssay Description:Inhibition of recombinant human DA transporter assessed as reduction in [3H]-DA reuptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
School Of Medicine Of University Of Electronic Science And Technology Of China

Curated by ChEMBL
LigandPNGBDBM50149942(CHEMBL3770663)
Affinity DataIC50:  40nMAssay Description:Inhibition of recombinant human DA transporter assessed as reduction in [3H]-DA reuptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
School Of Medicine Of University Of Electronic Science And Technology Of China

Curated by ChEMBL
LigandPNGBDBM50149940(CHEMBL3770651 | US10562878, Compound 203)
Affinity DataIC50:  44nMAssay Description:Inhibition of recombinant human 5-HT transporter expressed in HEK293 cells assessed as reduction in [3H]-5-HT reuptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
School Of Medicine Of University Of Electronic Science And Technology Of China

Curated by ChEMBL
LigandPNGBDBM50149947(CHEMBL3770126)
Affinity DataIC50:  70nMAssay Description:Inhibition of DAT in Wistar rat synaptosomes assessed as [3H]-DA reuptake by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCatechol O-methyltransferase(Rattus norvegicus (Rat))
School Of Medicine Of University Of Electronic Science And Technology Of China

Curated by ChEMBL
LigandPNGBDBM50149943(CHEMBL3770406)
Affinity DataIC50:  151nMAssay Description:Inhibition of rat COMTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
School Of Medicine Of University Of Electronic Science And Technology Of China

Curated by ChEMBL
LigandPNGBDBM50248106(CHEMBL461101 | ELTROMBOPAG | Eltrombopag olamine)
Affinity DataIC50:  690nMAssay Description:Inhibition of human ERG channel tail currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed