Compile Data Set for Download or QSAR
maximum 50k data
Found 44 Enz. Inhib. hit(s) with all data for entry = 50010213
TargetCytochrome P450 2E1(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50536234(CHEMBL4580214)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of CYP2E1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 4B1(Homo sapiens)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50536234(CHEMBL4580214)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of CYP450 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50536237(CHEMBL4572781)
Affinity DataEC50:  7nMAssay Description:Allosteric inhibition of HCV genotype 1a NS5A infected in human W11.8 cells assessed as reduction in viral RNA replication after 4 days by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50536236(CHEMBL4593452)
Affinity DataEC50:  21nMAssay Description:Allosteric inhibition of HCV genotype 1b NS5A infected in human l389lucubi- neo/NS3-375.1-containing Huh7ET cells assessed as RNA replication/transla...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50536238(CHEMBL4513308)
Affinity DataEC50:  16nMAssay Description:Allosteric inhibition of HCV genotype 1b NS5A infected in human l389lucubi- neo/NS3-375.1-containing Huh7ET cells assessed as RNA replication/transla...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50536234(CHEMBL4580214)
Affinity DataEC50:  120nMAssay Description:Inhibition of HCV genotype 1a NS5B M423V mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50536234(CHEMBL4580214)
Affinity DataEC50:  280nMAssay Description:Inhibition of HCV genotype 1a NS5B M423T mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50536234(CHEMBL4580214)
Affinity DataEC50:  400nMAssay Description:Inhibition of HCV genotype 1a NS5B L419I mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50536234(CHEMBL4580214)
Affinity DataEC50:  240nMAssay Description:Inhibition of HCV genotype 1a NS5B L419M mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50536234(CHEMBL4580214)
Affinity DataEC50:  4.80E+3nMAssay Description:Inhibition of HCV genotype 2a NS5AMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50536239(CHEMBL4537840)
Affinity DataEC50:  17nMAssay Description:Allosteric inhibition of HCV genotype 1b NS5A infected in human l389lucubi- neo/NS3-375.1-containing Huh7ET cells assessed as RNA replication/transla...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50536240(CHEMBL4543917)
Affinity DataEC50:  64nMAssay Description:Allosteric inhibition of HCV genotype 1b NS5A infected in human l389lucubi- neo/NS3-375.1-containing Huh7ET cells assessed as RNA replication/transla...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50536234(CHEMBL4580214)
Affinity DataEC50:  23nMAssay Description:Allosteric inhibition of HCV genotype 1b NS5A infected in human l389lucubi- neo/NS3-375.1-containing Huh7ET cells assessed as RNA replication/transla...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50536241(CHEMBL4559288)
Affinity DataEC50:  23nMAssay Description:Allosteric inhibition of HCV genotype 1b NS5A infected in human l389lucubi- neo/NS3-375.1-containing Huh7ET cells assessed as RNA replication/transla...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50536242(CHEMBL4579069)
Affinity DataEC50:  12nMAssay Description:Allosteric inhibition of HCV genotype 1b NS5A infected in human l389lucubi- neo/NS3-375.1-containing Huh7ET cells assessed as RNA replication/transla...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50536243(CHEMBL4556107)
Affinity DataEC50:  7nMAssay Description:Allosteric inhibition of HCV genotype 1b NS5A infected in human l389lucubi- neo/NS3-375.1-containing Huh7ET cells assessed as RNA replication/transla...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50536244(CHEMBL4522557)
Affinity DataEC50:  14nMAssay Description:Allosteric inhibition of HCV genotype 1b NS5A infected in human l389lucubi- neo/NS3-375.1-containing Huh7ET cells assessed as RNA replication/transla...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50536245(CHEMBL4552952)
Affinity DataEC50:  109nMAssay Description:Allosteric inhibition of HCV genotype 1b NS5A infected in human l389lucubi- neo/NS3-375.1-containing Huh7ET cells assessed as RNA replication/transla...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50536237(CHEMBL4572781)
Affinity DataEC50:  5nMAssay Description:Allosteric inhibition of HCV genotype 1b NS5A infected in human l389lucubi- neo/NS3-375.1-containing Huh7ET cells assessed as RNA replication/transla...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50536234(CHEMBL4580214)
Affinity DataEC50:  37nMAssay Description:Allosteric inhibition of HCV genotype 1a NS5A infected in human W11.8 cells assessed as reduction in viral RNA replication after 4 days by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50536241(CHEMBL4559288)
Affinity DataEC50:  51nMAssay Description:Allosteric inhibition of HCV genotype 1a NS5A infected in human W11.8 cells assessed as reduction in viral RNA replication after 4 days by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50536235(Lomibuvir | VX-222)
Affinity DataEC50:  53nMAssay Description:Allosteric inhibition of HCV genotype 1a NS5A infected in human W11.8 cells assessed as reduction in viral RNA replication after 4 days by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50536235(Lomibuvir | VX-222)
Affinity DataEC50:  66nMAssay Description:Allosteric inhibition of HCV genotype 1b NS5A infected in human l389lucubi- neo/NS3-375.1-containing Huh7ET cells assessed as RNA replication/transla...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50536235(Lomibuvir | VX-222)
Affinity DataEC50:  8.10E+3nMAssay Description:Inhibition of HCV genotype 2a NS5AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50536235(Lomibuvir | VX-222)
Affinity DataEC50:  310nMAssay Description:Inhibition of HCV genotype 1a NS5B M423T mutantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50536246(CHEMBL4537175)
Affinity DataEC50:  67nMAssay Description:Allosteric inhibition of HCV genotype 1b NS5A infected in human l389lucubi- neo/NS3-375.1-containing Huh7ET cells assessed as RNA replication/transla...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50536235(Lomibuvir | VX-222)
Affinity DataEC50:  65nMAssay Description:Inhibition of HCV genotype 1a NS5B M423V mutantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50536247(CHEMBL4521916)
Affinity DataEC50:  60nMAssay Description:Allosteric inhibition of HCV genotype 1b NS5A infected in human l389lucubi- neo/NS3-375.1-containing Huh7ET cells assessed as RNA replication/transla...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50536242(CHEMBL4579069)
Affinity DataEC50:  35nMAssay Description:Allosteric inhibition of HCV genotype 1a NS5A infected in human W11.8 cells assessed as reduction in viral RNA replication after 4 days by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50536235(Lomibuvir | VX-222)
Affinity DataEC50:  30nMAssay Description:Inhibition of HCV genotype 1a NS5B M423I mutantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50536248(CHEMBL4557273)
Affinity DataEC50:  190nMAssay Description:Allosteric inhibition of HCV genotype 1b NS5A infected in human l389lucubi- neo/NS3-375.1-containing Huh7ET cells assessed as RNA replication/transla...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50536238(CHEMBL4513308)
Affinity DataEC50:  24nMAssay Description:Allosteric inhibition of HCV genotype 1a NS5A infected in human W11.8 cells assessed as reduction in viral RNA replication after 4 days by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50536234(CHEMBL4580214)
Affinity DataEC50:  89nMAssay Description:Inhibition of HCV genotype 1a NS5B M423I mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50536234(CHEMBL4580214)
Affinity DataEC50:  340nMAssay Description:Allosteric inhibition of HCV genotype 1b NS5A infected in human l389lucubi- neo/NS3-375.1-containing Huh7ET cells assessed as RNA replication/transla...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50536249(CHEMBL4550700)
Affinity DataEC50:  6nMAssay Description:Allosteric inhibition of HCV genotype 1b NS5A infected in human l389lucubi- neo/NS3-375.1-containing Huh7ET cells assessed as RNA replication/transla...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50536250(CHEMBL4588925)
Affinity DataEC50:  66nMAssay Description:Allosteric inhibition of HCV genotype 1b NS5A infected in human l389lucubi- neo/NS3-375.1-containing Huh7ET cells assessed as RNA replication/transla...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50536251(CHEMBL4577336)
Affinity DataEC50:  160nMAssay Description:Allosteric inhibition of HCV genotype 1b NS5A infected in human l389lucubi- neo/NS3-375.1-containing Huh7ET cells assessed as RNA replication/transla...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50536252(CHEMBL4519311)
Affinity DataEC50:  51nMAssay Description:Allosteric inhibition of HCV genotype 1b NS5A infected in human l389lucubi- neo/NS3-375.1-containing Huh7ET cells assessed as RNA replication/transla...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50536235(Lomibuvir | VX-222)
Affinity DataEC50:  7nMAssay Description:Allosteric inhibition of HCV genotype 1b NS5A infected in human l389lucubi- neo/NS3-375.1-containing Huh7ET cells assessed as RNA replication/transla...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50536243(CHEMBL4556107)
Affinity DataEC50:  11nMAssay Description:Allosteric inhibition of HCV genotype 1a NS5A infected in human W11.8 cells assessed as reduction in viral RNA replication after 4 days by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50536235(Lomibuvir | VX-222)
Affinity DataEC50:  320nMAssay Description:Inhibition of HCV genotype 1a NS5B L419I mutantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50536236(CHEMBL4593452)
Affinity DataEC50:  32nMAssay Description:Allosteric inhibition of HCV genotype 1a NS5A infected in human W11.8 cells assessed as reduction in viral RNA replication after 4 days by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50536253(CHEMBL4572483)
Affinity DataEC50:  9nMAssay Description:Allosteric inhibition of HCV genotype 1b NS5A infected in human l389lucubi- neo/NS3-375.1-containing Huh7ET cells assessed as RNA replication/transla...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50536235(Lomibuvir | VX-222)
Affinity DataEC50:  320nMAssay Description:Inhibition of HCV genotype 1a NS5B L419M mutantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed