BindingDB PrimarySearch

Found 39 Enz. Inhib. hit(s) with all data for entry = 50049312

cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50238854(CHEBI:58987 | Revatio | Sildenafil Citrate | UK-92...)

IC50: 5.10nMAssay Description:Inhibition of PDE5A1 catalytic domain (535 to 860 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using [3H]cGMP as substrate afte...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase PC cid PC sid Similars

Details Article PubMed

cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50238849(CHEMBL4059555)

IC50: 5.40nMAssay Description:Inhibition of PDE5A1 catalytic domain (535 to 860 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using [3H]cGMP as substrate afte...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50238860(CHEMBL4099219)

IC50: 5.60nMAssay Description:Inhibition of PDE5A1 catalytic domain (535 to 860 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using [3H]cGMP as substrate afte...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50238851(CHEMBL4087872)

IC50: 16nMAssay Description:Inhibition of PDE5A1 catalytic domain (535 to 860 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using [3H]cGMP as substrate afte...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50238864(CHEMBL4099081)

IC50: 21nMAssay Description:Inhibition of PDE5A1 catalytic domain (535 to 860 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using [3H]cGMP as substrate afte...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50238858(CHEMBL4082746)

IC50: 30nMAssay Description:Inhibition of PDE5A1 catalytic domain (535 to 860 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using [3H]cGMP as substrate afte...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50238859(CHEMBL4069398)

IC50: 31nMAssay Description:Inhibition of PDE5A1 catalytic domain (535 to 860 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using [3H]cGMP as substrate afte...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50238862(CHEMBL4079069)

IC50: 50nMAssay Description:Inhibition of PDE5A1 catalytic domain (535 to 860 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using [3H]cGMP as substrate afte...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50238852(CHEMBL4084753)

IC50: 56nMAssay Description:Inhibition of PDE5A1 catalytic domain (535 to 860 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using [3H]cGMP as substrate afte...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50238860(CHEMBL4099219)

IC50: 58nMAssay Description:Inhibition of PDE6A (484 to 817 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using [3H]cGMP or [3H]cAMP as substrate after 15 m...More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50238850(CHEMBL4065489)

IC50: 77nMAssay Description:Inhibitory concentration (isomer B) against Angiotensin I converting enzymeMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50238855(CHEMBL4086923)

IC50: >100nMAssay Description:Inhibition of PDE5A1 catalytic domain (535 to 860 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using [3H]cGMP as substrate afte...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50238856(CHEMBL4088934)

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50238844(CHEMBL4068199)

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid

Details Article PubMed

cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50238861(CHEMBL4091487)

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50238845(CHEMBL4073050)

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50238863(CHEMBL4072265)

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50238865(CHEMBL4096629)

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50238853(CHEMBL4063667)

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50238847(CHEMBL4099915)

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50238848(CHEMBL4103327)

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50238857(CHEMBL4060717)

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50238846(CHEMBL4095575)

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50238860(CHEMBL4099219)

IC50: 153nMAssay Description:Inhibition of PDE10A (449 to 770 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using [3H]cGMP or [3H]cAMP as substrate after 15 ...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

cGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50238860(CHEMBL4099219)

IC50: 362nMAssay Description:Inhibition of PDE2A (580 to 919 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using [3H]cGMP or [3H]cAMP as substrate after 15 m...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

cAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50238860(CHEMBL4099219)

IC50: 2.77E+3nMAssay Description:Inhibition of PDE4D2 (86 to 413 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using [3H]cAMP or [3H]cGMP as substrate after 15 m...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50238860(CHEMBL4099219)

IC50: 6.22E+3nMAssay Description:Inhibition of PDE8A1 (480 to 820 residues) (unknown origin) using [3H]cGMP or [3H]cAMP as substrate after 15 mins by liquid scintillation counting me...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Cytochrome P450 1A2(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50238860(CHEMBL4099219)

IC50: 7.60E+3nMAssay Description:Inhibition of CYP1A2 in human microsomes in presence of NADPHMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50238860(CHEMBL4099219)

IC50: >1.00E+4nMAssay Description:Inhibition of PDE7A1 (130 to 482 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using [3H]cGMP or [3H]cAMP as substrate after 15 ...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50238860(CHEMBL4099219)

IC50: >1.00E+4nMAssay Description:Inhibition of PDE3A (679 to 1087 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using [3H]cAMP or [3H]cGMP as substrate after 15 ...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Potassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50238860(CHEMBL4099219)

IC50: >1.00E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells by automated patch clamp assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50238860(CHEMBL4099219)

IC50: >1.00E+4nMAssay Description:Inhibition of PDE1B (10 to 487 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using [3H]cAMP or [3H]cGMP as substrate after 15 mi...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50238860(CHEMBL4099219)

IC50: >1.00E+4nMAssay Description:Inhibition of PDE9A2 (181 to 506 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using [3H]cGMP or [3H]cAMP as substrate after 15 ...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Cytochrome P450 2C19(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50238860(CHEMBL4099219)

IC50: >2.00E+4nMAssay Description:Inhibition of CYP2C19 in human microsomes in presence of NADPHMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Cytochrome P450 2C8(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50238860(CHEMBL4099219)

IC50: >2.50E+4nMAssay Description:Inhibitory concentration (isomer A) against Angiotensin I converting enzymeMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Cytochrome P450 2C9(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50238860(CHEMBL4099219)

IC50: >2.50E+4nMAssay Description:Inhibition of CYP2C9 in human microsomes in presence of NADPHMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Cytochrome P450 2B6(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50238860(CHEMBL4099219)

IC50: >2.50E+4nMAssay Description:Inhibition of CYP2B6 in human microsomes in presence of NADPHMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Cytochrome P450 3A4(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50238860(CHEMBL4099219)

IC50: >2.50E+4nMAssay Description:Inhibition of CYP3A4 in human microsomes in presence of NADPHMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Cytochrome P450 2D6(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL

BDBM50238860(CHEMBL4099219)

IC50: >2.50E+4nMAssay Description:Inhibition of CYP2D6 in human microsomes in presence of NADPHMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Filter my 39 hits

Targets 18▿
- cGMP-specific 3',5'-cyclic phosphodiesterase 22
- High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A 1
- cGMP-dependent 3',5'-cyclic phosphodiesterase 1
- Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha 1
- cAMP-specific 3',5'-cyclic phosphodiesterase 4D 1
- Potassium voltage-gated channel subfamily H member 2 1
- High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A 1
- Cytochrome P450 1A2 1
- Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B 1
- cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A 1
- Cytochrome P450 2C9 1
- Cytochrome P450 2C19 1
- Cytochrome P450 2D6 1
- Cytochrome P450 2C8 1
- cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A 1
- Cytochrome P450 2B6 1
- Cytochrome P450 3A4 1
- High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A 1
Publications 1▿
- J Med Chem 60: 6622-6637 (2017) 39
Institutions 1▿
- Sun Yat-Sen University 39
Affinity: 5.1 to 2.5E+4 nM▿
- IC50 39
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1