BindingDB PrimarySearch_ki

Found 35 Enz. Inhib. hit(s) with all data for entry = 50002015

Serine/threonine-protein kinase B-raf(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50452149(CHEMBL4216073)

IC50: 0.200nMAssay Description:Inhibition of recombinant C-terminal his6-tagged B-Raf (437 to 765 residues) V600E mutant (unknown origin) catalytic domain expressed in baculovirus ...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed PDB

3D Structure (crystal)

Serine/threonine-protein kinase B-raf(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50452152(CHEMBL4217462)

IC50: 0.300nMAssay Description:Inhibition of recombinant C-terminal his6-tagged B-Raf (437 to 765 residues) V600E mutant (unknown origin) catalytic domain expressed in baculovirus ...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Serine/threonine-protein kinase B-raf(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50452150(CHEMBL4216386)

IC50: 0.300nMAssay Description:Inhibition of recombinant C-terminal his6-tagged B-Raf (437 to 765 residues) V600E mutant (unknown origin) catalytic domain expressed in baculovirus ...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Serine/threonine-protein kinase B-raf(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50452147(CHEMBL4204192)

IC50: 0.900nMAssay Description:Inhibition of recombinant C-terminal his6-tagged B-Raf (437 to 765 residues) V600E mutant (unknown origin) catalytic domain expressed in baculovirus ...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Mitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50452152(CHEMBL4217462)

IC50: 2nMAssay Description:Inhibition of P38 (unknown origin)More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Mitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50452151(CHEMBL4208527)

IC50: 2nMAssay Description:Inhibition of P38 (unknown origin)More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Serine/threonine-protein kinase B-raf(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50452151(CHEMBL4208527)

IC50: 3nMAssay Description:Inhibition of recombinant C-terminal his6-tagged B-Raf (437 to 765 residues) V600E mutant (unknown origin) catalytic domain expressed in baculovirus ...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Serine/threonine-protein kinase B-raf(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50452154(CHEMBL4205266)

IC50: 5nMAssay Description:Inhibition of recombinant C-terminal his6-tagged B-Raf (437 to 765 residues) V600E mutant (unknown origin) catalytic domain expressed in baculovirus ...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Serine/threonine-protein kinase B-raf(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50452148(CHEMBL4209163)

IC50: 6nMAssay Description:Inhibition of recombinant C-terminal his6-tagged B-Raf (437 to 765 residues) V600E mutant (unknown origin) catalytic domain expressed in baculovirus ...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Platelet-derived growth factor receptor alpha(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50452149(CHEMBL4216073)

IC50: 8nMAssay Description:Inhibition of PDGFRalpha (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Mitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50452154(CHEMBL4205266)

IC50: <11nMAssay Description:Inhibition of P38 (unknown origin)More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50452152(CHEMBL4217462)

IC50: 44nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Mast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50452149(CHEMBL4216073)

IC50: 52nMAssay Description:Inhibition of Kit (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Serine/threonine-protein kinase B-raf(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50452153(CHEMBL4211935)

IC50: 61nMAssay Description:Inhibition of recombinant C-terminal his6-tagged B-Raf (437 to 765 residues) V600E mutant (unknown origin) catalytic domain expressed in baculovirus ...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Ephrin type-A receptor 4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50452149(CHEMBL4216073)

IC50: 74nMAssay Description:Inhibition of EphA4 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50452154(CHEMBL4205266)

IC50: 110nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Ephrin type-B receptor 4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50452149(CHEMBL4216073)

IC50: 150nMAssay Description:Inhibition of EphB4 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Tyrosine-protein kinase Lyn(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50452149(CHEMBL4216073)

IC50: 170nMAssay Description:Inhibition of Lyn (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Mitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50452149(CHEMBL4216073)

IC50: 220nMAssay Description:Inhibition of P38 (unknown origin)More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50452149(CHEMBL4216073)

IC50: 320nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Mitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50452147(CHEMBL4204192)

IC50: 660nMAssay Description:Inhibition of P38 (unknown origin)More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Mitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50452153(CHEMBL4211935)

IC50: 1.60E+3nMAssay Description:Inhibition of P38 (unknown origin)More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50452147(CHEMBL4204192)

IC50: 2.00E+3nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50452150(CHEMBL4216386)

IC50: 2.70E+3nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Mitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50452150(CHEMBL4216386)

IC50: 3.10E+3nMAssay Description:Inhibition of P38 (unknown origin)More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50452153(CHEMBL4211935)

IC50: 1.10E+4nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Mitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50452148(CHEMBL4209163)

IC50: >2.50E+4nMAssay Description:Inhibition of P38 (unknown origin)More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar

Details Article PubMed

Serine/threonine-protein kinase B-raf(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50452147(CHEMBL4204192)

EC50: 770nMAssay Description:Inhibition of B-Raf V600E mutant in human A375 cells assessed as reduction in ERK phosphorylationMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Serine/threonine-protein kinase B-raf(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50452153(CHEMBL4211935)

EC50: 540nMAssay Description:Inhibition of B-Raf V600E mutant in human A375 cells assessed as reduction in ERK phosphorylationMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Serine/threonine-protein kinase B-raf(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50452154(CHEMBL4205266)

EC50: 130nMAssay Description:Inhibition of B-Raf V600E mutant in human A375 cells assessed as reduction in ERK phosphorylationMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Serine/threonine-protein kinase B-raf(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50452150(CHEMBL4216386)

EC50: 480nMAssay Description:Inhibition of B-Raf V600E mutant in human A375 cells assessed as reduction in ERK phosphorylationMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Serine/threonine-protein kinase B-raf(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50452148(CHEMBL4209163)

EC50: >1.00E+4nMAssay Description:Inhibition of B-Raf V600E mutant in human A375 cells assessed as reduction in ERK phosphorylationMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Serine/threonine-protein kinase B-raf(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50452152(CHEMBL4217462)

EC50: 25nMAssay Description:Inhibition of B-Raf V600E mutant in human A375 cells assessed as reduction in ERK phosphorylationMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Serine/threonine-protein kinase B-raf(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50452151(CHEMBL4208527)

EC50: 240nMAssay Description:Inhibition of B-Raf V600E mutant in human A375 cells assessed as reduction in ERK phosphorylationMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Serine/threonine-protein kinase B-raf(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL

PNG

BDBM50452149(CHEMBL4216073)

EC50: 230nMAssay Description:Inhibition of B-Raf V600E mutant in human A375 cells assessed as reduction in ERK phosphorylationMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed PDB

3D Structure (crystal)