Compile Data Set for Download or QSAR
maximum 50k data
Found 27 Enz. Inhib. hit(s) with all data for entry = 50012628
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50558881(CHEMBL4761836)
Affinity DataIC50:  900nMAssay Description:Inhibition of human ERG transfected in HEK293 cells assessed as reduction in channel current at -80 mV holding potential by whole-cell patch clamp me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50558880(CHEMBL4533529)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of human ERG transfected in HEK293 cells assessed as reduction in channel current at -80 mV holding potential by whole-cell patch clamp me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50236759(BMS-626529 | Temsavir)
Affinity DataIC50:  2.19E+4nMAssay Description:Inhibition of human ERG transfected in HEK293 cells assessed as reduction in channel current at -80 mV holding potential by whole-cell patch clamp me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2B6(Homo sapiens (Human))
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50558880(CHEMBL4533529)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of human liver microsome CYP2B6 using bupropion as substrate incubated for 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2B6(Homo sapiens (Human))
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50558881(CHEMBL4761836)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of human liver microsome CYP2B6 using bupropion as substrate incubated for 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C8(Homo sapiens (Human))
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50236759(BMS-626529 | Temsavir)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of human liver microsome CYP2C8 using paclitaxel as substrate incubated for 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C8(Homo sapiens (Human))
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50558880(CHEMBL4533529)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of human liver microsome CYP2C8 using paclitaxel as substrate incubated for 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C8(Homo sapiens (Human))
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50558881(CHEMBL4761836)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of human liver microsome CYP2C8 using paclitaxel as substrate incubated for 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50236759(BMS-626529 | Temsavir)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of human liver microsome CYP2C9 using diclofenac as substrate incubated for 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50558880(CHEMBL4533529)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of human liver microsome CYP2C9 using diclofenac as substrate incubated for 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50558881(CHEMBL4761836)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of human liver microsome CYP2C9 using diclofenac as substrate incubated for 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50236759(BMS-626529 | Temsavir)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of human liver microsome CYP2C19 using mephenytoin as substrate incubated for 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50558880(CHEMBL4533529)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of human liver microsome CYP2C19 using mephenytoin as substrate incubated for 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50558881(CHEMBL4761836)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of human liver microsome CYP2C19 using mephenytoin as substrate incubated for 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50236759(BMS-626529 | Temsavir)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of human liver microsome CYP2D6 using bufuralol as substrate incubated for 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50558880(CHEMBL4533529)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of human liver microsome CYP2D6 using bufuralol as substrate incubated for 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50558881(CHEMBL4761836)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of human liver microsome CYP2D6 using bufuralol as substrate incubated for 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50236759(BMS-626529 | Temsavir)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of human liver microsome CYP3A4 using testosterone as substrate incubated for 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50558880(CHEMBL4533529)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of human liver microsome CYP3A4 using testosterone as substrate incubated for 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50558881(CHEMBL4761836)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of human liver microsome CYP3A4 using testosterone as substrate incubated for 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50236759(BMS-626529 | Temsavir)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of human liver microsome CYP3A4 using midazolam as substrate incubated for 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50558880(CHEMBL4533529)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of human liver microsome CYP3A4 using midazolam as substrate incubated for 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50558881(CHEMBL4761836)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of human liver microsome CYP3A4 using midazolam as substrate incubated for 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2B6(Homo sapiens (Human))
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50236759(BMS-626529 | Temsavir)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of human liver microsome CYP2B6 using bupropion as substrate incubated for 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50558881(CHEMBL4761836)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of human liver microsome CYP1A2 using phenacetin as substrate incubated for 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50236759(BMS-626529 | Temsavir)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of human liver microsome CYP1A2 using phenacetin as substrate incubated for 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Lindsley F. Kimball Research Institute

Curated by ChEMBL
LigandPNGBDBM50558880(CHEMBL4533529)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of human liver microsome CYP1A2 using phenacetin as substrate incubated for 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed