Compile Data Set for Download or QSAR
Report error Found 61 Enz. Inhib. hit(s) with all data for entry = 50008922
TargetProtein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM415557(US10428104, Example 88)
Affinity DataKi:  0.0200nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50462572(CHEMBL4249337)
Affinity DataIC50: 0.130nMAssay Description:Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProtein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50523646(CHEMBL4541714)
Affinity DataIC50: 0.160nMAssay Description:Inhibition of PRMT5 in human A549 cells assessed as reduction in sDMA production after 48 hrs by Hoechst Stain/HCS CellMask Deep Red Stain based immu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
LigandPNGBDBM50523629(CHEMBL4564327)
Affinity DataIC50: 0.160nMAssay Description:Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
LigandPNGBDBM50523642(CHEMBL4539612)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
LigandPNGBDBM50523646(CHEMBL4541714)
Affinity DataIC50: 0.25nMAssay Description:Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50462572(CHEMBL4249337)
Affinity DataIC50: 0.25nMAssay Description:Inhibition of PRMT5 in human A549 cells assessed as reduction in sDMA production after 48 hrs by Hoechst Stain/HCS CellMask Deep Red Stain based immu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50523655(CHEMBL4577464)
Affinity DataIC50: 0.320nMAssay Description:Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50523641(CHEMBL4543007)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of PRMT5 in human A549 cells assessed as reduction in sDMA production after 48 hrs by Hoechst Stain/HCS CellMask Deep Red Stain based immu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
LigandPNGBDBM50523643(CHEMBL4454890)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
LigandPNGBDBM50523663(CHEMBL4536042)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of PRMT5 (unknown origin)/MEP50 (unknown origin) using histone H2 as substrate preincubated for 15 to 20 mins followed by S-[methyl-3H]ade...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
LigandPNGBDBM50523641(CHEMBL4543007)
Affinity DataIC50: 0.790nMAssay Description:Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
LigandPNGBDBM50523656(CHEMBL4579773)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50523654(CHEMBL4455651 | US10709709, Example 212)
Affinity DataIC50: 1nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50523661(CHEMBL4547524 | US10709709, Example 154)
Affinity DataIC50: 1nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50523654(CHEMBL4455651 | US10709709, Example 212)
Affinity DataIC50: 1nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
LigandPNGBDBM415554(US10428104, Example 85 | (2R,3R,4S,5R)-2-(4-amino-...)
Affinity DataIC50: 1nMAssay Description:Inhibition of full length N-terminal FLAG-tagged PRMT5 (unknown origin)/MEP50 (unknown origin) expressed in baculovirus infected Sf21 insect cells us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM415582(US10428104, Example 112)
Affinity DataIC50: 1nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50523631(CHEMBL4585734)
Affinity DataIC50: 1nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50523652(CHEMBL4445368 | US10709709, Example 89)
Affinity DataIC50: 1nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50523649(CHEMBL4448266 | US10709709, Example 198)
Affinity DataIC50: 1nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50523650(CHEMBL4541232 | US10709709, Example 91)
Affinity DataIC50: 1nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
LigandPNGBDBM415556(US10428104, Example 87)
Affinity DataIC50: 1nMAssay Description:Inhibition of full length N-terminal FLAG-tagged PRMT5 (unknown origin)/MEP50 (unknown origin) expressed in baculovirus infected Sf21 insect cells us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50523657(CHEMBL4563402)
Affinity DataIC50: 1nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProtein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50523638(CHEMBL4470815 | US10709709, Example 200)
Affinity DataIC50: 1nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50523656(CHEMBL4579773)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of PRMT5 in human A549 cells assessed as reduction in sDMA production after 48 hrs by Hoechst Stain/HCS CellMask Deep Red Stain based immu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
LigandPNGBDBM50523636(CHEMBL4457371)
Affinity DataIC50: 2nMAssay Description:Inhibition of PRMT5 (unknown origin)/MEP50 (unknown origin) using histone H2 as substrate preincubated for 15 to 20 mins followed by S-[methyl-3H]ade...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50523655(CHEMBL4577464)
Affinity DataIC50: 2nMAssay Description:Inhibition of PRMT5 in human A549 cells assessed as reduction in sDMA production after 48 hrs by Hoechst Stain/HCS CellMask Deep Red Stain based immu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50523651(CHEMBL4579108 | US10709709, Example 90)
Affinity DataIC50: 2nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
LigandPNGBDBM415529(US10428104, Example 60 | (Scheme R) (2R,3R,4S,5R)-...)
Affinity DataIC50: 2nMAssay Description:Inhibition of full length N-terminal FLAG-tagged PRMT5 (unknown origin)/MEP50 (unknown origin) expressed in baculovirus infected Sf21 insect cells us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50523658(CHEMBL4460647)
Affinity DataIC50: 2nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
LigandPNGBDBM50523653(CHEMBL4582424)
Affinity DataIC50: 3nMAssay Description:Inhibition of full length N-terminal FLAG-tagged PRMT5 (unknown origin)/MEP50 (unknown origin) expressed in baculovirus infected Sf21 insect cells us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
LigandPNGBDBM50523639(CHEMBL4460965)
Affinity DataIC50: 3nMAssay Description:Inhibition of full length N-terminal FLAG-tagged PRMT5 (unknown origin)/MEP50 (unknown origin) expressed in baculovirus infected Sf21 insect cells us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50523642(CHEMBL4539612)
Affinity DataIC50: 4nMAssay Description:Inhibition of PRMT5 in human A549 cells assessed as reduction in sDMA production after 48 hrs by Hoechst Stain/HCS CellMask Deep Red Stain based immu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
LigandPNGBDBM415556(US10428104, Example 87)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (1 to 637 residue) /full length human N-terminal His tagged MEP50 expressed in baculovir...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
LigandPNGBDBM50523644(CHEMBL4541070)
Affinity DataIC50: 5nMAssay Description:Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50523629(CHEMBL4564327)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of PRMT5 in human A549 cells assessed as reduction in sDMA production after 48 hrs by Hoechst Stain/HCS CellMask Deep Red Stain based immu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
LigandPNGBDBM50523630(CHEMBL4439077)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50523644(CHEMBL4541070)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of PRMT5 in human A549 cells assessed as reduction in sDMA production after 48 hrs by Hoechst Stain/HCS CellMask Deep Red Stain based immu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
LigandPNGBDBM50523634(CHEMBL4540972)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50523630(CHEMBL4439077)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of PRMT5 in human A549 cells assessed as reduction in sDMA production after 48 hrs by Hoechst Stain/HCS CellMask Deep Red Stain based immu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50523632(CHEMBL4454122)
Affinity DataIC50: 8.70nMAssay Description:Inhibition of PRMT5 (unknown origin) assessed as reduction in SAH formation using histone H2A and SAM incubated for 60 mins by high throughput mass s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
LigandPNGBDBM50523659(CHEMBL4557058)
Affinity DataIC50: 9nMAssay Description:Inhibition of full length N-terminal FLAG-tagged PRMT5 (unknown origin)/MEP50 (unknown origin) expressed in baculovirus infected Sf21 insect cells us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
LigandPNGBDBM50366992(CHEMBL4168754)
Affinity DataIC50: 9.5nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (1 to 637 residue) /full length human N-terminal His tagged MEP50 expressed in baculovir...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50523635(CHEMBL4556400)
Affinity DataIC50: 16nMAssay Description:Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
LigandPNGBDBM50523662(CHEMBL4465375)
Affinity DataIC50: 17nMAssay Description:Inhibition of PRMT5 (unknown origin)/MEP50 (unknown origin) using histone H2 as substrate preincubated for 15 to 20 mins followed by S-[methyl-3H]ade...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
LigandPNGBDBM50523645(CHEMBL4576734)
Affinity DataIC50: 20nMAssay Description:Inhibition of full-length human N-terminal FLAG-tagged PRMT5/full length N-terminal His6-tagged MEP50 (unknown origin) expressed in baculovirus infec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50523647(CHEMBL4524391)
Affinity DataIC50: 22nMAssay Description:Inhibition of PRMT5 (unknown origin) assessed as reduction in SAH formation using histone H2A and SAM incubated for 60 mins by high throughput mass s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
LigandPNGBDBM50523633(CHEMBL4554624)
Affinity DataIC50: 26nMAssay Description:Inhibition of PRMT5 (unknown origin)/MEP50 (unknown origin) using histone H2 as substrate preincubated for 15 to 20 mins followed by S-[methyl-3H]ade...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM50523634(CHEMBL4540972)
Affinity DataIC50: 51nMAssay Description:Inhibition of PRMT5 in human A549 cells assessed as reduction in sDMA production after 48 hrs by Hoechst Stain/HCS CellMask Deep Red Stain based immu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
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