Compile Data Set for Download or QSAR
maximum 50k data
Found 78 Enz. Inhib. hit(s) with all data for entry = 50010834
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50542404(CHEMBL4644578)
Affinity DataIC50:  6nMAssay Description:Inhibition of human recombinant JAK1 assessed as level of phosphorylation in presence of peptide substrate 5FAM-KKSRGDYMTMQUID and ATP by mobility sh...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM419652(US10463675, Example 95 | US10980815, Ex. No. 95 | ...)
Affinity DataIC50:  11nMAssay Description:Inhibition of human recombinant JAK1 assessed as level of phosphorylation in presence of peptide substrate 5FAM-KKSRGDYMTMQUID and ATP by mobility sh...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50542402(CHEMBL4644138)
Affinity DataIC50:  18nMAssay Description:Inhibition of human recombinant JAK1 assessed as level of phosphorylation in presence of peptide substrate 5FAM-KKSRGDYMTMQUID and ATP by mobility sh...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50542402(CHEMBL4644138)
Affinity DataIC50:  29nMAssay Description:Inhibition of human recombinant TYK2 assessed as level of phosphorylation in presence of peptide substrate 5FAM-KKSRGDYMTMQID and ATP by mobility shi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM330010(US10463675, Example 93 | US10980815, Ex. No. 93 | ...)
Affinity DataIC50:  29nMAssay Description:Inhibition of human recombinant TYK2 assessed as level of phosphorylation in presence of peptide substrate 5FAM-KKSRGDYMTMQID and ATP by mobility shi...More data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50542396(CHEMBL4638206)
Affinity DataIC50:  32nMAssay Description:Inhibition of human recombinant TYK2 assessed as level of phosphorylation in presence of peptide substrate 5FAM-KKSRGDYMTMQID and ATP by mobility shi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50542405(CHEMBL4637190)
Affinity DataIC50:  32nMAssay Description:Inhibition of human recombinant TYK2 assessed as level of phosphorylation in presence of peptide substrate 5FAM-KKSRGDYMTMQID and ATP by mobility shi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM419652(US10463675, Example 95 | US10980815, Ex. No. 95 | ...)
Affinity DataIC50:  32nMAssay Description:Inhibition of human recombinant TYK2 assessed as level of phosphorylation in presence of peptide substrate 5FAM-KKSRGDYMTMQID and ATP by mobility shi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50542404(CHEMBL4644578)
Affinity DataIC50:  37nMAssay Description:Inhibition of human recombinant TYK2 assessed as level of phosphorylation in presence of peptide substrate 5FAM-KKSRGDYMTMQID and ATP by mobility shi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50542405(CHEMBL4637190)
Affinity DataIC50:  41nMAssay Description:Inhibition of human recombinant JAK1 assessed as level of phosphorylation in presence of peptide substrate 5FAM-KKSRGDYMTMQUID and ATP by mobility sh...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM330010(US10463675, Example 93 | US10980815, Ex. No. 93 | ...)
Affinity DataIC50:  41nMAssay Description:Inhibition of human recombinant JAK1 assessed as level of phosphorylation in presence of peptide substrate 5FAM-KKSRGDYMTMQUID and ATP by mobility sh...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50542406(CHEMBL4648631)
Affinity DataIC50:  49nMAssay Description:Inhibition of human recombinant TYK2 assessed as level of phosphorylation in presence of peptide substrate 5FAM-KKSRGDYMTMQID and ATP by mobility shi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50542397(CHEMBL4640314)
Affinity DataIC50:  55nMAssay Description:Inhibition of human recombinant TYK2 assessed as level of phosphorylation in presence of peptide substrate 5FAM-KKSRGDYMTMQID and ATP by mobility shi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM330011(US10463675, Example 94 | US10980815, Ex. No. 94 | ...)
Affinity DataIC50:  56nMAssay Description:Inhibition of human recombinant TYK2 assessed as level of phosphorylation in presence of peptide substrate 5FAM-KKSRGDYMTMQID and ATP by mobility shi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50542401(CHEMBL4647223)
Affinity DataIC50:  57nMAssay Description:Inhibition of human recombinant TYK2 assessed as level of phosphorylation in presence of peptide substrate 5FAM-KKSRGDYMTMQID and ATP by mobility shi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50542403(CHEMBL4638906)
Affinity DataIC50:  67nMAssay Description:Inhibition of human recombinant TYK2 assessed as level of phosphorylation in presence of peptide substrate 5FAM-KKSRGDYMTMQID and ATP by mobility shi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50542397(CHEMBL4640314)
Affinity DataIC50:  81nMAssay Description:Inhibition of human recombinant JAK1 assessed as level of phosphorylation in presence of peptide substrate 5FAM-KKSRGDYMTMQUID and ATP by mobility sh...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50542406(CHEMBL4648631)
Affinity DataIC50:  81nMAssay Description:Inhibition of human recombinant JAK1 assessed as level of phosphorylation in presence of peptide substrate 5FAM-KKSRGDYMTMQUID and ATP by mobility sh...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM419652(US10463675, Example 95 | US10980815, Ex. No. 95 | ...)
Affinity DataIC50:  87nMAssay Description:Inhibition of JAK1/TYK2 in human whole blood assessed as reduction in IFNalpha-induced STAT phosphorylation by flow cytometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM330011(US10463675, Example 94 | US10980815, Ex. No. 94 | ...)
Affinity DataIC50:  113nMAssay Description:Inhibition of human recombinant JAK1 assessed as level of phosphorylation in presence of peptide substrate 5FAM-KKSRGDYMTMQUID and ATP by mobility sh...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50542396(CHEMBL4638206)
Affinity DataIC50:  122nMAssay Description:Inhibition of human recombinant JAK1 assessed as level of phosphorylation in presence of peptide substrate 5FAM-KKSRGDYMTMQUID and ATP by mobility sh...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50542404(CHEMBL4644578)
Affinity DataIC50:  128nMAssay Description:Inhibition of human recombinant JAK2 assessed as level of phosphorylation in presence of peptide substrate FITC-KGGEEEEYFELVKK and ATP by mobility sh...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50542399(CHEMBL4640981)
Affinity DataIC50:  139nMAssay Description:Inhibition of human recombinant TYK2 assessed as level of phosphorylation in presence of peptide substrate 5FAM-KKSRGDYMTMQID and ATP by mobility shi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
LigandPNGBDBM50542404(CHEMBL4644578)
Affinity DataIC50:  148nMAssay Description:Inhibition of JAK1/TYK2 in human whole blood assessed as reduction in IFNalpha-induced STAT phosphorylation by flow cytometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50542402(CHEMBL4644138)
Affinity DataIC50:  153nMAssay Description:Inhibition of JAK1/TYK2 in human whole blood assessed as reduction in IFNalpha-induced STAT phosphorylation by flow cytometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50542401(CHEMBL4647223)
Affinity DataIC50:  157nMAssay Description:Inhibition of human recombinant JAK1 assessed as level of phosphorylation in presence of peptide substrate 5FAM-KKSRGDYMTMQUID and ATP by mobility sh...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM330010(US10463675, Example 93 | US10980815, Ex. No. 93 | ...)
Affinity DataIC50:  191nMAssay Description:Inhibition of JAK1/TYK2 in human whole blood assessed as reduction in IFNalpha-induced STAT phosphorylation by flow cytometryMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50542404(CHEMBL4644578)
Affinity DataIC50:  194nMAssay Description:Inhibition of human recombinant JAK3 assessed as level of phosphorylation in presence of peptide substrate FITC-KGGEEEEYFELVKK and ATP by mobility sh...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50542398(CHEMBL4645039)
Affinity DataIC50:  209nMAssay Description:Inhibition of human recombinant TYK2 assessed as level of phosphorylation in presence of peptide substrate 5FAM-KKSRGDYMTMQID and ATP by mobility shi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM419652(US10463675, Example 95 | US10980815, Ex. No. 95 | ...)
Affinity DataIC50:  228nMAssay Description:Inhibition of human recombinant JAK2 assessed as level of phosphorylation in presence of peptide substrate FITC-KGGEEEEYFELVKK and ATP by mobility sh...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM419652(US10463675, Example 95 | US10980815, Ex. No. 95 | ...)
Affinity DataIC50:  255nMAssay Description:Inhibition of human recombinant JAK3 assessed as level of phosphorylation in presence of peptide substrate FITC-KGGEEEEYFELVKK and ATP by mobility sh...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50542397(CHEMBL4640314)
Affinity DataIC50:  260nMAssay Description:Inhibition of human recombinant JAK2 assessed as level of phosphorylation in presence of peptide substrate FITC-KGGEEEEYFELVKK and ATP by mobility sh...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM330010(US10463675, Example 93 | US10980815, Ex. No. 93 | ...)
Affinity DataIC50:  284nMAssay Description:Inhibition of human recombinant VEGFR2 in presence of substrate Ulight-CAGAGAIETDKEYYTVKD and Km ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50542403(CHEMBL4638906)
Affinity DataIC50:  304nMAssay Description:Inhibition of human recombinant JAK1 assessed as level of phosphorylation in presence of peptide substrate 5FAM-KKSRGDYMTMQUID and ATP by mobility sh...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50542396(CHEMBL4638206)
Affinity DataIC50:  329nMAssay Description:Inhibition of human recombinant JAK2 assessed as level of phosphorylation in presence of peptide substrate FITC-KGGEEEEYFELVKK and ATP by mobility sh...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50542402(CHEMBL4644138)
Affinity DataIC50:  340nMAssay Description:Inhibition of human recombinant JAK2 assessed as level of phosphorylation in presence of peptide substrate FITC-KGGEEEEYFELVKK and ATP by mobility sh...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
LigandPNGBDBM50542406(CHEMBL4648631)
Affinity DataIC50:  421nMAssay Description:Inhibition of JAK1/TYK2 in human whole blood assessed as reduction in IFNalpha-induced STAT phosphorylation by flow cytometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50542401(CHEMBL4647223)
Affinity DataIC50:  443nMAssay Description:Inhibition of JAK1/TYK2 in human whole blood assessed as reduction in IFNalpha-induced STAT phosphorylation by flow cytometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM330010(US10463675, Example 93 | US10980815, Ex. No. 93 | ...)
Affinity DataIC50:  652nMAssay Description:Inhibition of human recombinant JAK2 assessed as level of phosphorylation in presence of peptide substrate FITC-KGGEEEEYFELVKK and ATP by mobility sh...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50542405(CHEMBL4637190)
Affinity DataIC50:  676nMAssay Description:Inhibition of human recombinant JAK2 assessed as level of phosphorylation in presence of peptide substrate FITC-KGGEEEEYFELVKK and ATP by mobility sh...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50542399(CHEMBL4640981)
Affinity DataIC50:  774nMAssay Description:Inhibition of human recombinant JAK1 assessed as level of phosphorylation in presence of peptide substrate 5FAM-KKSRGDYMTMQUID and ATP by mobility sh...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50542402(CHEMBL4644138)
Affinity DataIC50:  949nMAssay Description:Inhibition of human recombinant JAK3 assessed as level of phosphorylation in presence of peptide substrate FITC-KGGEEEEYFELVKK and ATP by mobility sh...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
LigandPNGBDBM50542405(CHEMBL4637190)
Affinity DataIC50:  971nMAssay Description:Inhibition of JAK1/TYK2 in human whole blood assessed as reduction in IFNalpha-induced STAT phosphorylation by flow cytometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM330011(US10463675, Example 94 | US10980815, Ex. No. 94 | ...)
Affinity DataIC50:  1.13E+3nMAssay Description:Inhibition of human recombinant JAK2 assessed as level of phosphorylation in presence of peptide substrate FITC-KGGEEEEYFELVKK and ATP by mobility sh...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50542406(CHEMBL4648631)
Affinity DataIC50:  1.17E+3nMAssay Description:Inhibition of human recombinant JAK2 assessed as level of phosphorylation in presence of peptide substrate FITC-KGGEEEEYFELVKK and ATP by mobility sh...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50542404(CHEMBL4644578)
Affinity DataIC50:  1.49E+3nMAssay Description:Inhibition of JAK1/TYK2 in human whole blood assessed as EPO signalling in CD34+ cells by flow cytometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50542399(CHEMBL4640981)
Affinity DataIC50:  1.52E+3nMAssay Description:Inhibition of JAK1/TYK2 in human whole blood assessed as reduction in IFNalpha-induced STAT phosphorylation by flow cytometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50542401(CHEMBL4647223)
Affinity DataIC50:  1.62E+3nMAssay Description:Inhibition of human recombinant JAK2 assessed as level of phosphorylation in presence of peptide substrate FITC-KGGEEEEYFELVKK and ATP by mobility sh...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM330011(US10463675, Example 94 | US10980815, Ex. No. 94 | ...)
Affinity DataIC50:  1.73E+3nMAssay Description:Inhibition of JAK1/TYK2 in human whole blood assessed as reduction in IFNalpha-induced STAT phosphorylation by flow cytometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50542403(CHEMBL4638906)
Affinity DataIC50:  1.81E+3nMAssay Description:Inhibition of JAK1/TYK2 in human whole blood assessed as reduction in IFNalpha-induced STAT phosphorylation by flow cytometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
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