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Found 22 Enz. Inhib. hit(s) with all data for entry = 50012833
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM436689(N-Cyclopropyl-2-[2-oxo-6-[3-(trifluoromethyl)pheny...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells measured after 5 mins by Qpatch methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM437072(1-[2-(Azetidin-1-yl)-2-oxo-ethyl]-3-methyl-6-[3- (...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells measured after 5 mins by Qpatch methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM436773(1-[2-(Azetidin-1-yl)-2-oxo-ethyl]-6-(5-cyclopropyl...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells measured after 5 mins by Qpatch methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM436785(1-[2-(Azetidin-1-yl)-2-oxo-ethyl]-6-[4-(difluorome...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells measured after 5 mins by Qpatch methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM436762(1-[2-(Azetidin-1-yl)-2-oxo-ethyl]-6-[5-(difluorome...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells measured after 5 mins by Qpatch methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM436991(1-[2-(3-Fluoroazetidin-1-yl)-2-oxo-ethyl]-3-methyl...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells measured after 5 mins by Qpatch methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM436697(N,N-Dimethyl-2-[3-methyl-2-oxo-6-[5-(trifluorometh...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells measured after 5 mins by Qpatch methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM436990(1-[2-(Azetidin-1-yl)-2-oxo-ethyl]-3-methyl-6-(5-me...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells measured after 5 mins by Qpatch methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM436749(N,N-Dimethyl-2-[3-methyl-6-(4-methyl-2-thienyl)-2-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells measured after 5 mins by Qpatch methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409572(N,N-Dimethyl-2-[6-[5-(trifluoromethyl)-2-thienyl]p...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells measured after 5 mins by Qpatch methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM437082(N,N-Dimethyl-2-[3-methyl-2-oxo-6-[3-(trifluorometh...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells measured after 5 mins by Qpatch methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM436703(1-[2-(3-Fluoroazetidin-1-yl)-2-oxo-ethyl]-3-methyl...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells measured after 5 mins by Qpatch methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM409275(2-[6-(4-Fluoro-3-methyl-phenyl)pyrrolo[3,2-b]pyrid...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells measured after 5 mins by Qpatch methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM436696(1-[2-(Azetidin-1-yl)-2-oxo-ethyl]-3-methyl-6-[5-(t...)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate measured after 15 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM436696(1-[2-(Azetidin-1-yl)-2-oxo-ethyl]-3-methyl-6-[5-(t...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells measured after 5 mins by Qpatch methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM436696(1-[2-(Azetidin-1-yl)-2-oxo-ethyl]-3-methyl-6-[5-(t...)
Affinity DataIC50: <5.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate measured after 15 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM436696(1-[2-(Azetidin-1-yl)-2-oxo-ethyl]-3-methyl-6-[5-(t...)
Affinity DataIC50: <5.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using nifedipine as substrate measured after 15 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM436696(1-[2-(Azetidin-1-yl)-2-oxo-ethyl]-3-methyl-6-[5-(t...)
Affinity DataIC50: <5.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate measured after 15 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM436696(1-[2-(Azetidin-1-yl)-2-oxo-ethyl]-3-methyl-6-[5-(t...)
Affinity DataIC50: <5.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using tolbutamide as substrate measured after 15 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM436696(1-[2-(Azetidin-1-yl)-2-oxo-ethyl]-3-methyl-6-[5-(t...)
Affinity DataIC50: <5.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate measured after 15 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C8(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM436696(1-[2-(Azetidin-1-yl)-2-oxo-ethyl]-3-methyl-6-[5-(t...)
Affinity DataIC50: <5.00E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using amodiaquine as substrate measured after 15 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM436696(1-[2-(Azetidin-1-yl)-2-oxo-ethyl]-3-methyl-6-[5-(t...)
Affinity DataIC50: <5.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate measured after 15 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed