Found 55 Enz. Inhib. hit(s) with all data for entry = 50013163 TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University Of South Australia
Curated by ChEMBL
University Of South Australia
Curated by ChEMBL
Affinity DataKi: 4nMAssay Description:Inhibition of human GSKbeta H350L mutant (2 to 3nd residues) using YRRAAVPPSPSLSRHSSPHQS(p) EDEEE as substrate incubated for 40 mins in presence of [...More data for this Ligand-Target Pair
Affinity DataKi: 9nMAssay Description:Inhibition of CDK8/cyclin C (unknown origin) using RBER-IRStide as substrate incubated for 60 mins in presence of [gamma33P]ATP by scintillation coun...More data for this Ligand-Target Pair
3D Structure (crystal)TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
University Of South Australia
Curated by ChEMBL
University Of South Australia
Curated by ChEMBL
Affinity DataKi: 13nMAssay Description:Inhibition of human GSKalpha S449A mutant (2 to 3nd residues) using YRRAAVPPSPSLSRHSSPHQS(p) EDEEE as substrate incubated for 40 mins in presence of ...More data for this Ligand-Target Pair
Affinity DataKi: 14nMAssay Description:Inhibition of CDK8/cyclin C (unknown origin) using RBER-IRStide as substrate incubated for 60 mins in presence of [gamma33P]ATP by scintillation coun...More data for this Ligand-Target Pair
Affinity DataKi: 14nMAssay Description:Inhibition of CDK8/cyclin C (unknown origin) using RBER-IRStide as substrate incubated for 60 mins in presence of [gamma33P]ATP by scintillation coun...More data for this Ligand-Target Pair
Affinity DataKi: 16nMAssay Description:Inhibition of CDK8/cyclin C (unknown origin) using RBER-IRStide as substrate incubated for 60 mins in presence of [gamma33P]ATP by scintillation coun...More data for this Ligand-Target Pair
Affinity DataKi: 16nMAssay Description:Inhibition of CDK8/cyclin C (unknown origin) using RBER-IRStide as substrate incubated for 60 mins in presence of [gamma33P]ATP by scintillation coun...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University Of South Australia
Curated by ChEMBL
University Of South Australia
Curated by ChEMBL
Affinity DataKi: 18nMAssay Description:Inhibition of human GSKbeta H350L mutant (2 to 3nd residues) using YRRAAVPPSPSLSRHSSPHQS(p) EDEEE as substrate incubated for 40 mins in presence of [...More data for this Ligand-Target Pair
Affinity DataKi: 19nMAssay Description:Inhibition of CDK8/cyclin C (unknown origin) using RBER-IRStide as substrate incubated for 60 mins in presence of [gamma33P]ATP by scintillation coun...More data for this Ligand-Target Pair
Affinity DataKi: 21nMAssay Description:Inhibition of CDK8/cyclin C (unknown origin) using RBER-IRStide as substrate incubated for 60 mins in presence of [gamma33P]ATP by scintillation coun...More data for this Ligand-Target Pair
Affinity DataKi: 22nMAssay Description:Inhibition of CDK8/cyclin C (unknown origin) using RBER-IRStide as substrate incubated for 60 mins in presence of [gamma33P]ATP by scintillation coun...More data for this Ligand-Target Pair
Affinity DataKi: 22nMAssay Description:Inhibition of CDK8/cyclin C (unknown origin) using RBER-IRStide as substrate incubated for 60 mins in presence of [gamma33P]ATP by scintillation coun...More data for this Ligand-Target Pair
Affinity DataKi: 24nMAssay Description:Inhibition of CDK8/cyclin C (unknown origin) using RBER-IRStide as substrate incubated for 60 mins in presence of [gamma33P]ATP by scintillation coun...More data for this Ligand-Target Pair
Affinity DataKi: 26nMAssay Description:Inhibition of CDK8/cyclin C (unknown origin) using RBER-IRStide as substrate incubated for 60 mins in presence of [gamma33P]ATP by scintillation coun...More data for this Ligand-Target Pair
Affinity DataKi: 42nMAssay Description:Inhibition of CDK8/cyclin C (unknown origin) using RBER-IRStide as substrate incubated for 60 mins in presence of [gamma33P]ATP by scintillation coun...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
University Of South Australia
Curated by ChEMBL
University Of South Australia
Curated by ChEMBL
Affinity DataKi: 43nMAssay Description:Inhibition of human GSKalpha S449A mutant (2 to 3nd residues) using YRRAAVPPSPSLSRHSSPHQS(p) EDEEE as substrate incubated for 40 mins in presence of ...More data for this Ligand-Target Pair
Affinity DataKi: 48nMAssay Description:Inhibition of CDK8/cyclin C (unknown origin) using RBER-IRStide as substrate incubated for 60 mins in presence of [gamma33P]ATP by scintillation coun...More data for this Ligand-Target Pair
Affinity DataKi: 50nMAssay Description:Inhibition of CDK8/cyclin C (unknown origin) using RBER-IRStide as substrate incubated for 60 mins in presence of [gamma33P]ATP by scintillation coun...More data for this Ligand-Target Pair
Affinity DataKi: 52nMAssay Description:Inhibition of CDK8/cyclin C (unknown origin) using RBER-IRStide as substrate incubated for 60 mins in presence of [gamma33P]ATP by scintillation coun...More data for this Ligand-Target Pair
Affinity DataKi: 52nMAssay Description:Inhibition of CDK8/cyclin C (unknown origin) using RBER-IRStide as substrate incubated for 60 mins in presence of [gamma33P]ATP by scintillation coun...More data for this Ligand-Target Pair
Affinity DataKi: 56nMAssay Description:Inhibition of CDK8/cyclin C (unknown origin) using RBER-IRStide as substrate incubated for 60 mins in presence of [gamma33P]ATP by scintillation coun...More data for this Ligand-Target Pair
Affinity DataKi: 58nMAssay Description:Inhibition of CDK8/cyclin C (unknown origin) using RBER-IRStide as substrate incubated for 60 mins in presence of [gamma33P]ATP by scintillation coun...More data for this Ligand-Target Pair
TargetProtein kinase C theta type(Homo sapiens (Human))
University Of South Australia
Curated by ChEMBL
University Of South Australia
Curated by ChEMBL
Affinity DataKi: 61nMAssay Description:Inhibition of human full length PKCtheta using histone H1 as substrate incubated for 40 mins in presence of [gamma-33P]-ATP by scintillation counting...More data for this Ligand-Target Pair
Affinity DataKi: 66nMAssay Description:Inhibition of CDK8/cyclin C (unknown origin) using RBER-IRStide as substrate incubated for 60 mins in presence of [gamma33P]ATP by scintillation coun...More data for this Ligand-Target Pair
Affinity DataKi: 79nMAssay Description:Inhibition of CDK8/cyclin C (unknown origin) using RBER-IRStide as substrate incubated for 60 mins in presence of [gamma33P]ATP by scintillation coun...More data for this Ligand-Target Pair
TargetProtein kinase C theta type(Homo sapiens (Human))
University Of South Australia
Curated by ChEMBL
University Of South Australia
Curated by ChEMBL
Affinity DataKi: 109nMAssay Description:Inhibition of human full length PKCtheta using histone H1 as substrate incubated for 40 mins in presence of [gamma-33P]-ATP by scintillation counting...More data for this Ligand-Target Pair
Affinity DataKi: 114nMAssay Description:Inhibition of CDK8/cyclin C (unknown origin) using RBER-IRStide as substrate incubated for 60 mins in presence of [gamma33P]ATP by scintillation coun...More data for this Ligand-Target Pair
Affinity DataKi: 124nMAssay Description:Inhibition of CDK8/cyclin C (unknown origin) using RBER-IRStide as substrate incubated for 60 mins in presence of [gamma33P]ATP by scintillation coun...More data for this Ligand-Target Pair
TargetProtein kinase C theta type(Homo sapiens (Human))
University Of South Australia
Curated by ChEMBL
University Of South Australia
Curated by ChEMBL
Affinity DataKi: 134nMAssay Description:Inhibition of human full length PKCtheta using histone H1 as substrate incubated for 40 mins in presence of [gamma-33P]-ATP by scintillation counting...More data for this Ligand-Target Pair
Affinity DataKi: 138nMAssay Description:Inhibition of CDK8/cyclin C (unknown origin) using RBER-IRStide as substrate incubated for 60 mins in presence of [gamma33P]ATP by scintillation coun...More data for this Ligand-Target Pair
Affinity DataKi: 156nMAssay Description:Inhibition of CDK8/cyclin C (unknown origin) using RBER-IRStide as substrate incubated for 60 mins in presence of [gamma33P]ATP by scintillation coun...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
University Of South Australia
Curated by ChEMBL
University Of South Australia
Curated by ChEMBL
Affinity DataKi: 231nMAssay Description:Inhibition of human GSKalpha S449A mutant (2 to 3nd residues) using YRRAAVPPSPSLSRHSSPHQS(p) EDEEE as substrate incubated for 40 mins in presence of ...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University Of South Australia
Curated by ChEMBL
University Of South Australia
Curated by ChEMBL
Affinity DataKi: 345nMAssay Description:Inhibition of human GSKbeta H350L mutant (2 to 3nd residues) using YRRAAVPPSPSLSRHSSPHQS(p) EDEEE as substrate incubated for 40 mins in presence of [...More data for this Ligand-Target Pair
Affinity DataKi: 346nMAssay Description:Inhibition of CDK8/cyclin C (unknown origin) using RBER-IRStide as substrate incubated for 60 mins in presence of [gamma33P]ATP by scintillation coun...More data for this Ligand-Target Pair
Affinity DataKi: 458nMAssay Description:Inhibition of CDK8/cyclin C (unknown origin) using RBER-IRStide as substrate incubated for 60 mins in presence of [gamma33P]ATP by scintillation coun...More data for this Ligand-Target Pair
Affinity DataKi: 645nMAssay Description:Inhibition of CDK8/cyclin C (unknown origin) using RBER-IRStide as substrate incubated for 60 mins in presence of [gamma33P]ATP by scintillation coun...More data for this Ligand-Target Pair
Affinity DataKi: 670nMAssay Description:Inhibition of CDK8/cyclin C (unknown origin) using RBER-IRStide as substrate incubated for 60 mins in presence of [gamma33P]ATP by scintillation coun...More data for this Ligand-Target Pair
Affinity DataKi: 700nMAssay Description:Inhibition of CDK8/cyclin C (unknown origin) using RBER-IRStide as substrate incubated for 60 mins in presence of [gamma33P]ATP by scintillation coun...More data for this Ligand-Target Pair
Affinity DataKi: 1.09E+3nMAssay Description:Inhibition of CDK8/cyclin C (unknown origin) using RBER-IRStide as substrate incubated for 60 mins in presence of [gamma33P]ATP by scintillation coun...More data for this Ligand-Target Pair
Affinity DataKi: 1.30E+3nMAssay Description:Inhibition of CDK8/cyclin C (unknown origin) using RBER-IRStide as substrate incubated for 60 mins in presence of [gamma33P]ATP by scintillation coun...More data for this Ligand-Target Pair
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
University Of South Australia
Curated by ChEMBL
University Of South Australia
Curated by ChEMBL
Affinity DataKi: 1.77E+3nMAssay Description:Inhibition of CDK9/Cyclin T1 (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
University Of South Australia
Curated by ChEMBL
University Of South Australia
Curated by ChEMBL
Affinity DataKi: 1.90E+3nMAssay Description:Inhibition of CDK1/cyclin-B (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 2.03E+3nMAssay Description:Inhibition of CDK8/cyclin C (unknown origin) using RBER-IRStide as substrate incubated for 60 mins in presence of [gamma33P]ATP by scintillation coun...More data for this Ligand-Target Pair
Affinity DataKi: 3.14E+3nMAssay Description:Inhibition of CDK8/cyclin C (unknown origin) using RBER-IRStide as substrate incubated for 60 mins in presence of [gamma33P]ATP by scintillation coun...More data for this Ligand-Target Pair
Affinity DataKi: 4.19E+3nMAssay Description:Inhibition of CDK8/cyclin C (unknown origin) using RBER-IRStide as substrate incubated for 60 mins in presence of [gamma33P]ATP by scintillation coun...More data for this Ligand-Target Pair
Affinity DataIC50: 2.11E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam 1-hydroxylation as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 4.59E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam 1-hydroxylation as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University Of South Australia
Curated by ChEMBL
University Of South Australia
Curated by ChEMBL
Affinity DataIC50: 1.09E+4nMAssay Description:Inhibition of human ERG expressed in CHO cellsMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University Of South Australia
Curated by ChEMBL
University Of South Australia
Curated by ChEMBL
Affinity DataIC50: 1.47E+4nMAssay Description:Inhibition of human ERG expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using tolbutamide 4-hydroxylation as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
