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Found 84 Enz. Inhib. hit(s) with all data for entry = 50016424
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL
LigandPNGBDBM412060(2-amino-6-fluoro-N-[5-fluoro-4-[4-[4-(oxetan-3-yl)...)
Affinity DataKi: <0.150nMAssay Description:Binding affinity to ATR (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPurchase
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TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50084621(BMN 673 | Talazoparib)
Affinity DataKi:  0.580nMAssay Description:Binding affinity to PARP1 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50446130(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
Affinity DataKi:  1.40nMAssay Description:Binding affinity to PARP1 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL
LigandPNGBDBM209932(2-[(2R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-...)
Affinity DataKi:  3.30nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL
LigandPNGBDBM209932(2-[(2R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-...)
Affinity DataKi:  18nMAssay Description:Inhibition of PARP2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50594892(CHEMBL5192303)
Affinity DataKi: <100nMAssay Description:Inhibition of DNA-PK (unknown origin) assessed as inhibition constant using Glu-Pro-Pro-Leu-Ser-Gln-Glu-Ala-Phe-Ala-Asp-Leu-Trp-Lys-Lys-Lys peptide a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50594891(CHEMBL5171087)
Affinity DataKi: <100nMAssay Description:Inhibition of DNA-PK (unknown origin) assessed as inhibition constant using Glu-Pro-Pro-Leu-Ser-Gln-Glu-Ala-Phe-Ala-Asp-Leu-Trp-Lys-Lys-Lys peptide a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50594028(CHEMBL5176874)
Affinity DataIC50:  0.25nMAssay Description:Inhibition of PARP1 (unknown origin) incubated for 1 hr by chemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50084621(BMN 673 | Talazoparib)
Affinity DataIC50:  0.570nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL
LigandPNGBDBM245474(US9428503, 1)
Affinity DataIC50:  0.580nMAssay Description:Inhibition of ATM (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50594893(CHEMBL5188771)
Affinity DataIC50:  0.590nMAssay Description:Inhibition of PARP1 (unknown origin) incubated for 1 hr by chemiluminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL
LigandPNGBDBM413450(7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]pyridi...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of DNA-PK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPurchasePDB
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50520033(CHEMBL4461382)
Affinity DataIC50:  0.780nMAssay Description:Inhibition of PARP1 (unknown origin) incubated for 1 hr by chemiluminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50594881(CHEMBL5178683)
Affinity DataIC50:  1nMAssay Description:Inhibition of human DNA-PK using p53 as substrate incubated for 30 mins in presence of by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50594890(CHEMBL5205796)
Affinity DataIC50:  1nMAssay Description:Inhibition of ATM in human MCF7 cells using etoposide as substrate incubated for 1 hr by Cell Western assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50594889(CHEMBL5175568)
Affinity DataIC50:  1nMAssay Description:Inhibition of ATM in human MCF7 cells using etoposide as substrate incubated for 1 hr by Cell Western assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50594890(CHEMBL5205796)
Affinity DataIC50:  1nMAssay Description:Inhibition of full-length human DNA-PK expressed in baculovirus expression system using p53 as substrate incubated for 1 hr in presence of ATP by ELI...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50594889(CHEMBL5175568)
Affinity DataIC50:  1nMAssay Description:Inhibition of full-length human DNA-PK expressed in baculovirus expression system using p53 as substrate incubated for 1 hr in presence of ATP by ELI...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL
LigandPNGBDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)
Affinity DataIC50:  1nMAssay Description:Inhibition of PARP2 (unknown origin)More data for this Ligand-Target Pair
TargetWee1-like protein kinase(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50594904(CHEMBL5199347)
Affinity DataIC50:  1nMAssay Description:Displacement of tracer 178 from N-terminal GST-fused human WEE1 (215 to 646 residues) expressed in baculovirus expression system preincubated for 5 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50594899(CHEMBL5194825)
Affinity DataIC50: <1nMAssay Description:Inhibition of N-terminal GST-tagged full-length recombinant human CHK1 expressed in baculovirus infected Sf9 insect cells using FAM-P10 peptide as su...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50084621(BMN 673 | Talazoparib)
Affinity DataIC50:  1nMAssay Description:Inhibition of PARP2 (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50524300(LY2606368 | Prexasertib | US11564920, Example Prex...)
Affinity DataIC50: <1nMAssay Description:Inhibition of CHK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50594883(CHEMBL5183684)
Affinity DataIC50:  1nMAssay Description:Inhibition of human DNA-PK using p53 as substrate incubated for 30 mins in presence of by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL
LigandPNGBDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50446130(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of PARP2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50594879(CHEMBL5171429)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of ATM (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50446130(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
TargetWee1-like protein kinase(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50594903(CHEMBL5197954)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of N-terminal GST-tagged wild-type WEE1 (215 to 646 residues) (unknown origin) expressed in Sf21 insect cells incubated for 60 mins in pre...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50594884(CHEMBL5197528)
Affinity DataIC50:  2nMAssay Description:Inhibition of human DNA-PK using p53 as substrate incubated for 30 mins in presence of by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50316226((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of PARP2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50594900(CHEMBL5186119)
Affinity DataIC50:  2.5nMAssay Description:Displacement of tracer 178 from WEE1 (unknown origin) incubated for 1 hr by Lantha Screen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50594872(CHEMBL5193835)
Affinity DataIC50:  3nMAssay Description:Inhibition of human FLAG-tagged ATR/c-Myc-tagged ATRIP expressed in mammalian expression system using p53 as substrate incubated for 2 hrs by fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50594902(CHEMBL5194787)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of N-terminal GST-tagged wild-type WEE1 (215 to 646 residues) (unknown origin) expressed in Sf21 insect cells incubated for 60 mins in pre...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50520040(CHEMBL4438741)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of PARP1 (unknown origin) incubated for 1 hr by chemiluminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50316226((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50594880(CHEMBL5182423)
Affinity DataIC50:  4nMAssay Description:Inhibition of ATM (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50594873(CHEMBL5171719)
Affinity DataIC50:  4nMAssay Description:Inhibition of human FLAG-tagged ATR/c-Myc-tagged ATRIP expressed in mammalian expression system using p53 as substrate incubated for 2 hrs by fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50594882(CHEMBL5184207)
Affinity DataIC50:  4nMAssay Description:Inhibition of human DNA-PK using p53 as substrate incubated for 30 mins in presence of by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50594028(CHEMBL5176874)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of tankyrase 2 (unknown origin) incubated for 1 hr by chemiluminescence based assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50594901(CHEMBL5197623)
Affinity DataIC50:  4.80nMAssay Description:Displacement of tracer 178 from WEE1 (unknown origin) incubated for 1 hr by Lantha Screen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50520037(CHEMBL4470724)
Affinity DataIC50:  4.90nMAssay Description:Inhibition of PARP1 (unknown origin) incubated for 1 hr by chemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50240826(AZD-1775 | MK-1775 | US11124518, Example AZD1775 |...)
Affinity DataIC50:  5.20nMAssay Description:Inhibition of WEE1 (unknown origin)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50562648(CHEMBL4744783)
Affinity DataIC50:  5.80nMAssay Description:Inhibition of PI3K-alpha (unknown origin) incubated for 40 mins in presence of ATP by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50562648(CHEMBL4744783)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of PARP1 (unknown origin) incubated for 1 hr by chemiluminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50594893(CHEMBL5188771)
Affinity DataIC50:  6.5nMAssay Description:Inhibition of tankyrase 2 (unknown origin) incubated for 1 hr by chemiluminescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50562646(CHEMBL4758337)
Affinity DataIC50:  7.30nMAssay Description:Inhibition of PARP1 (unknown origin) incubated for 1 hr by chemiluminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL
LigandPNGBDBM412060(2-amino-6-fluoro-N-[5-fluoro-4-[4-[4-(oxetan-3-yl)...)
Affinity DataIC50:  8nMAssay Description:Inhibition of ATR (unknown origin)-driven CHK1 phosphorylationMore data for this Ligand-Target Pair
Ligand InfoPurchase
In DepthDetails PubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50524300(LY2606368 | Prexasertib | US11564920, Example Prex...)
Affinity DataIC50:  8nMAssay Description:Inhibition of CHK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Hubei Polytechnic University

Curated by ChEMBL
LigandPNGBDBM50520034(CHEMBL4541731)
Affinity DataIC50:  9.60nMAssay Description:Inhibition of PARP1 (unknown origin) incubated for 1 hr by chemiluminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
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