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Target
E3 ubiquitin-protein ligase parkin
Ligand
BDBM562076
Substrate
n/a
Meas. Tech.
In Vitro Enzyme Activity and Drug Binding
EC50
5000±n/a nM
Citation
 Springer, W; Fiesel, FC; Caulfield, TR Small molecule activators of Parkin enzyme function US Patent  US11401255 Publication Date 8/2/2022 
Target
Name:
E3 ubiquitin-protein ligase parkin
Synonyms:
PARK2 | PRKN | PRKN_HUMAN | Parkin | Parkin RBR E3 ubiquitin-protein ligase | Parkinson disease protein 2 | Parkinson juvenile disease protein 2
Type:
Protein
Mol. Mass.:
51645.70
Organism:
Human
Description:
O60260
Residue:
465
Sequence:
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
  
Inhibitor
Name:
BDBM562076
Synonyms:
US11401255, Compound # 10
Type:
Small organic molecule
Emp. Form.:
C21H25N3O
Mol. Mass.:
335.4427
SMILES:
O=C(Cn1ccnc1)Nc1ccc(cc1)C12CC3CC(CC(C3)C1)C2 |TLB:18:19:23:17.22.16,22:17:24:23.21.20,22:21:24:17.18.16,THB:18:17:23:24.19.20|
Structure:
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