Reaction Details Report a problem with these data
Target
E3 ubiquitin-protein ligase parkin
Ligand
BDBM562078
Substrate
n/a
Meas. Tech.
In Vitro Enzyme Activity and Drug Binding
EC50
5000±n/a nM
Citation
 Springer, W; Fiesel, FC; Caulfield, TR Small molecule activators of Parkin enzyme function US Patent  US11401255 Publication Date 8/2/2022 
Target
Name:
E3 ubiquitin-protein ligase parkin
Synonyms:
PARK2 | PRKN | PRKN_HUMAN | Parkin | Parkin RBR E3 ubiquitin-protein ligase | Parkinson disease protein 2 | Parkinson juvenile disease protein 2
Type:
Protein
Mol. Mass.:
51645.70
Organism:
Human
Description:
O60260
Residue:
465
Sequence:
MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPRCHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
  
Inhibitor
Name:
BDBM562078
Synonyms:
US11401255, Compound # 12
Type:
Small organic molecule
Emp. Form.:
C18H14F3N3O
Mol. Mass.:
345.3185
SMILES:
FC(F)(F)c1cc(NC(=O)Cn2ccnc2)ccc1-c1ccccc1
Structure:
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