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Target
hek293 luciferase
Ligand
BDBM578539
Substrate
n/a
Meas. Tech.
HEK293 luciferase
EC50
261±n/a nM
Citation
 Bartholomeus, J; Bürli, R; Jarvis, R; Johnstone, S; Ostenfeld, T; Terstiege, I; Travagli, M; Turcotte, S Small molecule modulators of the BTB domain of Keap1 US Patent  US11479539 Publication Date 10/25/2022 
Target
Name:
Gag-Pol polyprotein [588-1147,M628L,D654N,M771V,L797W,T802Y]
Synonyms:
HIV RT (41L/67N/210W/215Y/184V) | POL_HV1H2 | gag-pol
Type:
n/a
Mol. Mass.:
64571.45
Organism:
Human immunodeficiency virus type 1 group M subtype B (isolate HXB2)
Description:
P04585[588-1147,M628L,D654N,M771V,L797W,T802Y]
Residue:
560
Sequence:
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPVFAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIGQHRTKIEELRQHLWRWGLYTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQAIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDKLVSAGIRKVL
  
Inhibitor
Name:
BDBM578539
Synonyms:
7-methoxy-4-7- (4-methyl-1,3- thiazol-2-yl)-4- oxospiro[2.5]oct- 5-ene-5- carbonitrile (Enantiomer A) | US11479539, Compound 140 | US11479539, Compound 59
Type:
Small organic molecule
Emp. Form.:
C14H14N2O2S
Mol. Mass.:
274.338
SMILES:
COC1(CC2(CC2)C(=O)C(=C1)C#N)c1nc(C)cs1 |c:10|
Structure:
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