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Target
Glutaminyl-peptide cyclotransferase
Ligand
BDBM309910
Substrate
n/a
Meas. Tech.
Spectrophotometric Assay
Ki
4930±n/a nM
Citation
 Buchholz, M; Heiser, U; Niestroj, AJ; Sommer, R Inhibitors of glutaminyl cyclase US Patent  US9656991 Publication Date 5/23/2017 
Target
Name:
Glutaminyl-peptide cyclotransferase
Synonyms:
Glutaminyl Cyclase | Glutaminyl cyclase (QC) | Glutaminyl-peptide cyclotransferase | Glutaminyl-peptide cyclotransferase precursor (QC) | Glutaminyl-tRNA cyclotransferase | Glutamyl cyclase (QC) | QPCT | QPCT_HUMAN
Type:
Enzyme
Mol. Mass.:
40877.05
Organism:
Homo sapiens (Human)
Description:
Q16769
Residue:
361
Sequence:
MAGGRHRRVVGTLHLLLLVAALPWASRGVSPSASAWPEEKNYHQPAILNSSALRQIAEGTSISEMWQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSFSNIISTLNPTAKRHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLSLKTVSDSKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARGTSQLHGMDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYGGVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYLHL
  
Inhibitor
Name:
BDBM309910
Synonyms:
1- (benzo[c][1,2,5]thia- diazol-5-yl)-3-(1H- benzo[d]imidazol-5- yl)thiourea | US9656991, 24
Type:
Small organic molecule
Emp. Form.:
C14H10N6S2
Mol. Mass.:
326.399
SMILES:
S=C(Nc1ccc2[nH]cnc2c1)Nc1ccc2nsnc2c1
Structure:
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