Reaction Details Report a problem with these data
Target
Glutaminyl-peptide cyclotransferase
Ligand
BDBM309922
Substrate
n/a
Meas. Tech.
Spectrophotometric Assay
Ki
412±n/a nM
Citation
 Buchholz, M; Heiser, U; Niestroj, AJ; Sommer, R Inhibitors of glutaminyl cyclase US Patent  US9656991 Publication Date 5/23/2017 
Target
Name:
Glutaminyl-peptide cyclotransferase
Synonyms:
Glutaminyl Cyclase | Glutaminyl cyclase (QC) | Glutaminyl-peptide cyclotransferase | Glutaminyl-peptide cyclotransferase precursor (QC) | Glutaminyl-tRNA cyclotransferase | Glutamyl cyclase (QC) | QPCT | QPCT_HUMAN
Type:
Enzyme
Mol. Mass.:
40877.05
Organism:
Homo sapiens (Human)
Description:
Q16769
Residue:
361
Sequence:
MAGGRHRRVVGTLHLLLLVAALPWASRGVSPSASAWPEEKNYHQPAILNSSALRQIAEGTSISEMWQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSFSNIISTLNPTAKRHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLSLKTVSDSKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARGTSQLHGMDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYGGVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYLHL
  
Inhibitor
Name:
BDBM309922
Synonyms:
1-mesityl-3-(3-(4- methyl-1H-imidazol- 1-yl)propyl)thiourea | US9656991, 36
Type:
Small organic molecule
Emp. Form.:
C17H24N4S
Mol. Mass.:
316.464
SMILES:
Cc1cn(CCCNC(=S)Nc2c(C)cc(C)cc2C)cn1
Structure:
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