Reaction Details Report a problem with these data
Target
Fibroblast growth factor receptor 4
Ligand
BDBM604879
Substrate
n/a
Meas. Tech.
Enzymologic Experiment of FGFR4
IC50
0.400±n/a nM
Citation
 Gao, P; Xiu, W; Wang, S; Liu, L; Bao, R FGFR4 inhibitor, preparation method therefor, and applications thereof US Patent  US11667631 Publication Date 6/6/2023 
Target
Name:
Fibroblast growth factor receptor 4
Synonyms:
CD_antigen: CD334 FGFR4 | FGFR-4 | FGFR4 | FGFR4_HUMAN | Fibroblast growth factor receptor | Fibroblast growth factor receptor 4 (FGFR4) | JK2 | JTK2 | TKF
Type:
Protein
Mol. Mass.:
87957.45
Organism:
Homo sapiens (Human)
Description:
P22455
Residue:
802
Sequence:
MRLLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRAERGGHWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWTAAAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQFSLESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDSVFSHDPLPLGSSSFPFGSGVQT
  
Inhibitor
Name:
BDBM604879
Synonyms:
N-(5-Cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)-7-formyl-6-((3-carbonyl-1,4-oxazepin-4-yl)methyl)-3,4-dihydro-1,8-naphthyridin-1(21-1)-carboxamide | US11667631, Example 6
Type:
Small organic molecule
Emp. Form.:
C25H29N7O5
Mol. Mass.:
507.5417
SMILES:
COCCNc1cc(NC(=O)N2CCCc3cc(CN4CCCOCC4=O)c(C=O)nc23)ncc1C#N
Structure:
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