Reaction Details Report a problem with these data
Target
Complement factor D
Ligand
BDBM558894
Substrate
n/a
Meas. Tech.
Factor D Esterolytic Assay
IC50
<1000±n/a nM
Citation
 Kotian, PL; Babu, YS; Zhang, W; Lu, P; Wu, M; Lv, W; Nguyen, TX; Dang, Z; Chintareddy, VR; Kumar, VS; Raman, K Substituted benzofuran, benzopyrrole, benzothiophene, and structurally related complement inhibitors US Patent  US11708347 Publication Date 7/25/2023 
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
  
Inhibitor
Name:
BDBM558894
Synonyms:
US11370774, Compound 11a | US11708347, Compound 11a
Type:
Small organic molecule
Emp. Form.:
C29H30N4O3
Mol. Mass.:
482.5735
SMILES:
CCOC(=O)Cc1ccccc1NC(=O)c1cc(-c2cccc(CN)c2)c2cn(CC3CC3)nc2c1
Structure:
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