Reaction Details Report a problem with these data
Target
Casein kinase II subunit alpha
Ligand
BDBM616478
Substrate
n/a
Meas. Tech.
Radiometric Kinase Assay
IC50
100.0±n/a nM
Citation
 Bancet, A; Cochet, C; Filhol-Cochet, O; Krimm, I; Lomberget, T; Le Borgne, M INDOLE DERIVATIVES AND USES THEREOF FOR TREATING A CANCER US Patent  US20230278983 Publication Date 9/7/2023 
Target
Name:
Casein kinase II subunit alpha
Synonyms:
CK II | CK2 | CK2- alpha | CK2A1 | CSK21_HUMAN | CSNK2A1 | Casein kinase 2 | Casein kinase II (CK2) | Casein kinase II alpha/beta | Casein kinase II subunit alpha (CK2 alpha) | Casein kinase II subunit alpha (CK2A1) | Casein kinase II subunit alpha (CK2a I174A) | Casein kinase II subunit alpha (CK2a V66A) | Casein kinase II subunit alpha (CK2a dm V66I174AA) | Casein kinase II subunit alpha (CK2a)
Type:
Enzyme
Mol. Mass.:
45151.12
Organism:
Homo sapiens (Human)
Description:
P68400
Residue:
391
Sequence:
MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLGPLAGSPVIAAANPLGMPVPAAAGAQQ
  
Inhibitor
Name:
BDBM616478
Synonyms:
US20230278983, Code AB1416
Type:
Small organic molecule
Emp. Form.:
C35H39FN6O5S
Mol. Mass.:
674.785
SMILES:
CCC(=O)c1[nH]c2ccc(F)cc2c1-c1cn(CC2CCN(CCNS(=O)(=O)c3ccc(cc3)-c3c(CO)cccc3OC)CC2)nn1
Structure:
Search PDB for entries with ligand similarity: