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Target
Tyrosine-protein kinase BTK [14-552]
Ligand
BDBM324350
Substrate
n/a
Meas. Tech.
In Vitro BTK Kinase Assay
IC50
<1.000±n/a nM
Citation
 Hopkins, BT; Ma, B; Prince, R; Marx, I; Lyssikatos, JP; Zheng, F; Peterson, M; Patience, DB Inhibiting agents for bruton's tyrosine kinase US Patent  US11858926 Publication Date 1/2/2024 
Target
Name:
Tyrosine-protein kinase BTK [14-552]
Synonyms:
Tyrosine-protein kinase BTK (14-552)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
62318.43
Organism:
Homo sapiens (Human)
Description:
Q06187[14-552]
Residue:
539
Sequence:
SQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYT
  
Inhibitor
Name:
BDBM324350
Synonyms:
5-(tert-butyl)-N-(8- hydroxy-2-(2-((1-methyl- 1H-pyrazol-4- yl)amino)pyrimidin-4- yl)-6,7,8,9-tetrahydro- 5H-benzo[7]annulen-5- yl)-1,3,4-oxadiazole-2- carboxamide | US10189829, Compound 150 | US10227341, Compound 150 | US10961237, Compound 150 | US11858926, Compound 150
Type:
Small organic molecule
Emp. Form.:
C26H30N8O3
Mol. Mass.:
502.5682
SMILES:
Cn1cc(Nc2nccc(n2)-c2ccc3C(CCC(O)Cc3c2)NC(=O)c2nnc(o2)C(C)(C)C)cn1
Structure:
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