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Target
Tyrosine-protein kinase BTK [14-552]
Ligand
BDBM324351
Substrate
n/a
Meas. Tech.
In Vitro BTK Kinase Assay
IC50
<1.000±n/a nM
Citation
 Hopkins, BT; Ma, B; Prince, R; Marx, I; Lyssikatos, JP; Zheng, F; Peterson, M; Patience, DB Inhibiting agents for bruton's tyrosine kinase US Patent  US11858926 Publication Date 1/2/2024 
Target
Name:
Tyrosine-protein kinase BTK [14-552]
Synonyms:
Tyrosine-protein kinase BTK (14-552)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
62318.43
Organism:
Homo sapiens (Human)
Description:
Q06187[14-552]
Residue:
539
Sequence:
SQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYT
  
Inhibitor
Name:
BDBM324351
Synonyms:
(R)-5-(tert-butyl)-N-(2- (2-((5,6-dihydro-4H- pyrrolo[1,2-b]pyrazol-3- yl)amino)pyrimidin-4- yl)-6,7,8,9-tetrahydro- 5H-benzo[7]annulen-5- yl)-1,2,4-oxadiazole-3- carboxamide | US10189829, Compound 152 | US10227341, Compound 152 | US10961237, Compound 152 | US11858926, Compound 152
Type:
Small organic molecule
Emp. Form.:
C28H32N8O2
Mol. Mass.:
512.6061
SMILES:
CC(C)(C)c1nc(no1)C(=O)N[C@@H]1CCCCc2cc(ccc12)-c1ccnc(Nc2cnn3CCCc23)n1 |r|
Structure:
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