Reaction Details Report a problem with these data
Target
Pantothenate kinase 3
Ligand
BDBM649477
Substrate
n/a
Meas. Tech.
hPanK3 IC50
IC50
5.80±0.4 nM
Citation
 Lee, RE; Tangallapally, RP; Rock, CO; Jackowski, S; Edwards, AV; Yun, MK; Subramanian, C; Zamboni, R; Reddy, TJ Small molecule modulators of pantothenate kinases US Patent  US11891378 Publication Date 2/6/2024 
Target
Name:
Pantothenate kinase 3
Synonyms:
PANK3 | PANK3_HUMAN | Pantothenate kinase 3 | Pantothenic acid kinase 3 | hPanK3
Type:
PROTEIN
Mol. Mass.:
41093.59
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109587
Residue:
370
Sequence:
MKIKDAKKPSFPWFGMDIGGTLVKLSYFEPIDITAEEEQEEVESLKSIRKYLTSNVAYGSTGIRDVHLELKDLTLFGRRGNLHFIRFPTQDLPTFIQMGRDKNFSTLQTVLCATGGGAYKFEKDFRTIGNLHLHKLDELDCLVKGLLYIDSVSFNGQAECYYFANASEPERCQKMPFNLDDPYPLLVVNIGSGVSILAVHSKDNYKRVTGTSLGGGTFLGLCSLLTGCESFEEALEMASKGDSTQADKLVRDIYGGDYERFGLPGWAVASSFGNMIYKEKRESVSKEDLARATLVTITNNIGSVARMCAVNEKINRVVFVGNFLRVNTLSMKLLAYALDYWSKGQLKALFLEHEGYFGAVGALLGLPNFS
  
Inhibitor
Name:
BDBM649477
Synonyms:
US11891378, Example 7
Type:
Small organic molecule
Emp. Form.:
C19H21ClN4O
Mol. Mass.:
356.849
SMILES:
Clc1ccc(nn1)N1CCN(CC1)C(=O)Cc1ccc(cc1)C1CC1
Structure:
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