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Target
Sphingosine 1-phosphate receptor 5
Ligand
BDBM321301
Substrate
n/a
Meas. Tech.
In Vitro Functional Activity (Agonism) on Human S1P5 Receptors
EC50
31.6±n/a nM
Citation
 Stoit, A; Iwema Bakker, WI; Coolen, HK; van Dongen, MJ; Leflemme, NJ; Hobson, A Spiro-cyclic amine derivatives as S1P modulators US Patent  US10179791 Publication Date 1/15/2019 
Target
Name:
Sphingosine 1-phosphate receptor 5
Synonyms:
EDG8 | Endothelial differentiation sphingolipid G-protein-coupled receptor 8 | S1P5 | S1PR5 | S1PR5_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor Edg-8
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
41796.42
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
398
Sequence:
MESGLLRPAPVSEVIVLHYNYTGKLRGARYQPGAGLRADAVVCLAVCAFIVLENLAVLLVLGRHPRFHAPMFLLLGSLTLSDLLAGAAYAANILLSGPLTLKLSPALWFAREGGVFVALTASVLSLLAIALERSLTMARRGPAPVSSRGRTLAMAAAAWGVSLLLGLLPALGWNCLGRLDACSTVLPLYAKAYVLFCVLAFVGILAAICALYARIYCQVRANARRLPARPGTAGTTSTRARRKPRSLALLRTLSVVLLAFVACWGPLFLLLLLDVACPARTCPVLLQADPFLGLAMANSLLNPIIYTLTNRDLRHALLRLVCCGRHSCGRDPSGSQQSASAAEASGGLRRCLPPGLDGSFSGSERSSPQRDGLDTSGSTGSPGAPTAARTLVSEPAAD
  
Inhibitor
Name:
BDBM321301
Synonyms:
US10179791, Compound 68 | US10807991, Compound 68
Type:
Small organic molecule
Emp. Form.:
C24H27Cl2NO4
Mol. Mass.:
464.381
SMILES:
CCc1ccc(Cl)c(COc2ccc3c(OCC33CCN(CCC(O)=O)CC3)c2)c1Cl
Structure:
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