Reaction Details Report a problem with these data
Target
Methionine aminopeptidase
Ligand
BDBM17872
Substrate
BDBM17848
Meas. Tech.
MetAP Inhibition Assay
pH
7.5±n/a
Temperature
295.15±n/a K
IC50
>100000±n/a nM
Km
1410000±270000 nM
kcat
11.91±0.88 1/sec
Citation
 Oefner, C; Douangamath, A; D'Arcy, A; Häfeli, S; Mareque, D; Mac Sweeney, A; Padilla, J; Pierau, S; Schulz, H; Thormann, M; Wadman, S; Dale, GE The 1.15A crystal structure of the Staphylococcus aureus methionyl-aminopeptidase and complexes with triazole based inhibitors. J Mol Biol 332:13-21 (2003) [PubMed]  Article 
Target
Name:
Methionine aminopeptidase
Synonyms:
MAP1_STAAW | MetAP | Methionine Aminopeptidase (MAP) | Peptidase M | SaMetAP-1 | map
Type:
Enzyme
Mol. Mass.:
27494.40
Organism:
Staphylococcus aureus
Description:
P0A079
Residue:
252
Sequence:
MIVKTEEELQALKEIGYICAKVRNTMQAATKPGITTKELDNIAKELFEEYGAISAPIHDENFPGQTCISVNEEVAHGIPSKRVIREGDLVNIDVSALKNGYYADTGISFVVGESDDPMKQKVCDVATMAFENAIAKVKPGTKLSNIGKAVHNTARQNDLKVIKNLTGHGVGLSLHEAPAHVLNYFDPKDKTLLTEGMVLAIEPFISSNASFVTEGKNEWAFETSDKSFVAQIEHTVIVTKDGPILTTKIEEE
  
Inhibitor
Name:
BDBM17872
Synonyms:
1,2,4-triazole derivative. | 3-(benzylsulfanyl)-4-methyl-4H-1,2,4-triazole | MCB 2720
Type:
Small organic molecule
Emp. Form.:
C10H11N3S
Mol. Mass.:
205.279
SMILES:
Cn1cnnc1SCc1ccccc1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM17848
Synonyms:
1-[(2S)-2-amino-4-(methylsulfanyl)butanoyl]-N-(4-nitrophenyl)pyrrolidine-2-carboxamide | Met-Pro-pNA
Type:
Small organic molecule
Emp. Form.:
C16H22N4O4S
Mol. Mass.:
366.435
SMILES:
CSCC[C@H](N)C(=O)N1CCCC1C(=O)Nc1ccc(cc1)[N+]([O-])=O |r|
Structure:
Search PDB for entries with ligand similarity: