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Target
Bromodomain-containing protein 4 [342-460]
Ligand
BDBM362669
Substrate
n/a
Meas. Tech.
AlphaScreen Assay
IC50
<25±n/a nM
Citation
 Combs, AP; Sparks, RB Tricyclic heterocycles as bet protein inhibitors US Patent  US9834565 Publication Date 12/5/2017 
Target
Name:
Bromodomain-containing protein 4 [342-460]
Synonyms:
BRD4 | BRD4-BD2 (aa 342-460) | BRD4_HUMAN | Bromodomain containing 4 (aa 342-460) | Bromodomain-containing protein 4 (BRD4)(BD2) | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
13783.81
Organism:
Homo sapiens (Human)
Description:
a.a. 342-460 (BRD4-BD2)
Residue:
119
Sequence:
PAPEKSSKVSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDE
  
Inhibitor
Name:
BDBM362669
Synonyms:
N-{1-[(4S)-7-(3,5-dimethylisoxazol-4-yl)- 4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4- de][1,4]benzoxazin-2-yl]piperidin-4-yl}-N- methylcyclopropanesulfonamide | US10227359, Example 24 | US9834565, Example 24
Type:
Small organic molecule
Emp. Form.:
C28H32N6O4S
Mol. Mass.:
548.656
SMILES:
CN(C1CCN(CC1)c1nc2ccc(-c3c(C)noc3C)c3OCC(c4ccccn4)n1c23)S(=O)(=O)C1CC1 |(-.97,7.44,;-1.74,6.11,;-.97,4.78,;-1.74,3.44,;-.97,2.11,;.57,2.11,;1.34,3.44,;.57,4.78,;1.34,.77,;2.88,.77,;3.44,-.66,;4.78,-1.43,;4.78,-2.97,;3.44,-3.74,;3.44,-5.28,;2.2,-6.18,;.73,-5.71,;2.67,-7.65,;4.21,-7.65,;4.69,-6.18,;6.15,-5.71,;2.11,-2.97,;.77,-3.74,;-.56,-2.97,;-.56,-1.43,;-1.89,-.66,;-3.23,-1.43,;-4.56,-.66,;-4.56,.88,;-3.23,1.65,;-1.89,.88,;.77,-.66,;2.11,-1.43,;-3.28,6.11,;-3.28,7.65,;-3.28,4.57,;-4.82,6.11,;-6.15,5.34,;-6.15,6.88,)|
Structure:
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