Reaction Details Report a problem with these data
Target
Cathepsin S
Ligand
BDBM19859
Substrate
BDBM19490
Meas. Tech.
Enzyme Inhibition Assay
IC50
13±n/a nM
EC50
40±n/a nM
Citation
 Falgueyret, JP; Desmarais, S; Oballa, R; Black, WC; Cromlish, W; Khougaz, K; Lamontagne, S; Massé, F; Riendeau, D; Toulmond, S; Percival, MD Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional selectivity. J Med Chem 48:7535-43 (2005) [PubMed]  Article 
Target
Name:
Cathepsin S
Synonyms:
CATS_MOUSE | Cats | Ctss
Type:
Enzyme
Mol. Mass.:
38476.67
Organism:
Mus musculus (Mouse)
Description:
O70370
Residue:
340
Sequence:
MRAPGHAAIRWLFWMPLVCSVAMEQLQRDPTLDYHWDLWKKTHEKEYKDKNEEEVRRLIWEKNLKFIMIHNLEYSMGMHTYQVGMNDMGDMTNEEILCRMGALRIPRQSPKTVTFRSYSNRTLPDTVDWREKGCVTEVKYQGSCGACWAFSAVGALEGQLKLKTGKLISLSAQNLVDCSNEEKYGNKGCGGGYMTEAFQYIIDNGGIEADASYPYKATDEKCHYNSKNRAATCSRYIQLPFGDEDALKEAVATKGPVSVGIDASHSSFFFYKSGVYDDPSCTGNVNHGVLVVGYGTLDGKDYWLVKNSWGLNFGDQGYIRMARNNKNHCGIASYCSYPEI
  
Inhibitor
Name:
BDBM19859
Synonyms:
(2S)-N-(cyanomethyl)-3-cyclohexyl-2-(phenylformamido)propanamide | phenyl-containing analogue, 14
Type:
Small organic molecule
Emp. Form.:
C18H23N3O2
Mol. Mass.:
313.3941
SMILES:
O=C(NCC#N)[C@H](CC1CCCCC1)NC(=O)c1ccccc1 |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM19490
Synonyms:
Cbz-Val-Val-Arg-AMC | Fluorogenic substrate | Z-Val-Val-Arg-AMC
Type:
n/a
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
n/a
Structure: