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Target
Signal transducer and activator of transcription 1-alpha/beta
Ligand
BDBM20282
Substrate
c-fos sis inducible element (hSIE)
Meas. Tech.
Electrophoretic Mobility Shift Assay (EMSA)
pH
7.8±n/a
Temperature
295.15±n/a K
IC50
159000±6000 nM
Citation
 Siddiquee, KA; Gunning, PT; Glenn, M; Katt, WP; Zhang, S; Schroeck, C; Sebti, SM; Jove, R; Hamilton, AD; Turkson, J An oxazole-based small-molecule Stat3 inhibitor modulates Stat3 stability and processing and induces antitumor cell effects. ACS Chem Biol 2:787-98 (2007) [PubMed]  Article 
Target
Name:
Signal transducer and activator of transcription 1-alpha/beta
Synonyms:
STAT1 | STAT1_HUMAN | Signal transducer and activator of transcription 1-alpha/beta | Transcription Factor STAT1 | Transcription factor ISGF-3 components p91/p84 | signal transducer and activator of transcription 1 isoform alpha
Type:
Cytosolic Transcription Factor
Mol. Mass.:
87327.69
Organism:
Homo sapiens (Human)
Description:
Stat1 was expressed in sf9 cells from a baculovirus encoding the recombinant proteins. Stat1 dimer binds to DNA.
Residue:
750
Sequence:
MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDLLSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQRFNQAQSGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQNREHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTELTQNALINDELVEWKRRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKNKQVLWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYNLKVKVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQKNAGTRTNEGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNMLVAEPRNLSFFLTPPCARWAQLSEVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNASPDGLIPWTRFCKENINDKNFPFWLWIESILELIKKHLLPLWNDGCIMGFISKERERALLKDQQPGTFLLRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIPENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDGPKGTGYIKTELISVSEVHPSRLQTTDNLLPMSPEEFDEVSRIVGSVEFDSMMNTV
  
Inhibitor
Name:
BDBM20282
Synonyms:
4-{[4-(hexylcarbamoyl)-2-(naphthalen-1-yl)-1,3-oxazol-5-yl]methyl}phenoxyphosphonic acid | S3I-M2001
Type:
Small organic molecule
Emp. Form.:
C27H29N2O6P
Mol. Mass.:
508.5027
SMILES:
CCCCCCNC(=O)c1nc(oc1Cc1ccc(OP(O)(O)=O)cc1)-c1cccc2ccccc12
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
c-fos sis inducible element (hSIE)
Synonyms:
32P-labeled c-fos sis inducible element (hSIE)
Type:
Oligonucleotide
Mol. Mass.:
2192.56
Organism:
n/a
Description:
hSIE derived from the c-fos gene promoter.
Residue:
24
Sequence:
AGCTTCATTTCCCGTAAATCCCTA