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Target
Neutrophil elastase
Ligand
BDBM23702
Substrate
BDBM23699
Meas. Tech.
Human Neutrophil Elastase Inhibition Assay
pH
7.5±n/a
Temperature
298.15±n/a K
Ki
24±n/a nM
Citation
 Schepetkin, IA; Khlebnikov, AI; Quinn, MT N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase. J Med Chem 50:4928-38 (2007) [PubMed]  Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM23702
Synonyms:
3-[(2,4-dimethylphenyl)carbonyl]-1-[(4-fluorophenyl)carbonyl]-1H-pyrazole | N-Benzoylpyrazole deriv., 4
Type:
Small organic molecule
Emp. Form.:
C19H15FN2O2
Mol. Mass.:
322.333
SMILES:
Cc1ccc(C(=O)c2ccn(n2)C(=O)c2ccc(F)cc2)c(C)c1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM23699
Synonyms:
N-methylsuccinyl-Ala-Ala-Pro-Val-7-amino-4-methylcoumarin
Type:
Chromogenic substrate
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
n/a
Structure: